Trait
Inability to speak
Clinical name: Mutism
Complete lack of speech or verbal communication in a person despite attempts to engage in conversation. Mutism as a phenomena assumes the individual has previous capacity for speech and in the pediatric population it assumes that the person is past the age of typical language development.
Summary
- Also called
- Muteness
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
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Get my Genome Test52 genes linked to Inability to speak
Changes in these genes cause rare conditions in which Inability to speak is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| LRRC7leucine rich repeat containing 7 | Always | In 1 condition |
| ACTBactin beta | Very often (80–99%) | In 1 condition |
| ACTG1actin gamma 1 | Very often (80–99%) | In 1 condition |
| CKAP2Lcytoskeleton associated protein 2L | Very often (80–99%) | In 1 condition |
| EHMT1euchromatic histone lysine methyltransferase 1 | Very often (80–99%) | In 1 condition |
| PLECplectin | Very often (80–99%) | In 1 condition |
| PRPS1phosphoribosyl pyrophosphate synthetase 1 | Very often (80–99%) | In 1 condition |
| SMARCA2SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2 | Very often (80–99%) | In 1 condition |
| TCF4transcription factor 4 | Very often (80–99%) | In 1 condition |
| ATP1A3ATPase Na+/K+ transporting subunit alpha 3 | Often (30–79%) | In 2 conditions |
| CDKL5cyclin dependent kinase like 5 | Often (30–79%) | In 1 condition |
| FGFR1fibroblast growth factor receptor 1 | Often (30–79%) | In 1 condition |
| GABBR2gamma-aminobutyric acid type B receptor subunit 2 | Often (30–79%) | In 1 condition |
| GRIN1glutamate ionotropic receptor NMDA type subunit 1 | Often (30–79%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Often (30–79%) | In 1 condition |
| MECP2methyl-CpG binding protein 2 | Often (30–79%) | In 1 condition |
| NTNG1netrin G1 | Often (30–79%) | In 1 condition |
| SLC19A3solute carrier family 19 member 3 | Often (30–79%) | In 1 condition |
| SLC9A6solute carrier family 9 member A6 | Often (30–79%) | In 2 conditions |
| SMC1Astructural maintenance of chromosomes 1A | Often (30–79%) | In 1 condition |
| UBE3Cubiquitin protein ligase E3C | Often (30–79%) | In 1 condition |
| AMER1APC membrane recruitment protein 1 | Sometimes (5–29%) | In 1 condition |
| ASAH1N-acylsphingosine amidohydrolase 1 | Sometimes (5–29%) | In 1 condition |
| CHCHD10coiled-coil-helix-coiled-coil-helix domain containing 10 | Sometimes (5–29%) | In 1 condition |
| CHMP2Bcharged multivesicular body protein 2B | Sometimes (5–29%) | In 3 conditions |
| COX7Bcytochrome c oxidase subunit 7B | Sometimes (5–29%) | In 1 condition |
| CTNNB1catenin beta 1 | Sometimes (5–29%) | In 1 condition |
| FUSFUS RNA binding protein | Sometimes (5–29%) | In 1 condition |
| GRIN2Aglutamate ionotropic receptor NMDA type subunit 2A | Sometimes (5–29%) | In 1 condition |
| GRNgranulin precursor | Sometimes (5–29%) | In 3 conditions |
| HCCSholocytochrome c synthase | Sometimes (5–29%) | In 1 condition |
| HNRNPA1heterogeneous nuclear ribonucleoprotein A1 | Sometimes (5–29%) | In 1 condition |
| HNRNPA2B1heterogeneous nuclear ribonucleoprotein A2/B1 | Sometimes (5–29%) | In 1 condition |
| HTThuntingtin | Sometimes (5–29%) | In 1 condition |
| MAPTmicrotubule associated protein tau | Sometimes (5–29%) | In 3 conditions |
| NDUFB11NADH:ubiquinone oxidoreductase subunit B11 | Sometimes (5–29%) | In 1 condition |
| PIK3C2Aphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha | Sometimes (5–29%) | In 1 condition |
| PRDM8PR/SET domain 8 | Sometimes (5–29%) | In 2 conditions |
| PSEN1presenilin 1 | Sometimes (5–29%) | In 2 conditions |
| SLC2A3solute carrier family 2 member 3 | Sometimes (5–29%) | In 1 condition |
Show 12 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| SQSTM1sequestosome 1 | Sometimes (5–29%) | In 3 conditions |
| TARDBPTAR DNA binding protein | Sometimes (5–29%) | In 1 condition |
| TBK1TANK binding kinase 1 | Sometimes (5–29%) | In 2 conditions |
| TMEM106Btransmembrane protein 106B | Sometimes (5–29%) | In 2 conditions |
| TRANK1tetratricopeptide repeat and ankyrin repeat containing 1 | Sometimes (5–29%) | In 1 condition |
| TREM2triggering receptor expressed on myeloid cells 2 | Sometimes (5–29%) | In 2 conditions |
| VCPvalosin containing protein | Sometimes (5–29%) | In 4 conditions |
| CSF1Rcolony stimulating factor 1 receptor | Not recorded | In 2 conditions |
| FTLferritin light chain | Not recorded | In 1 condition |
| GLE1GLE1 RNA export mediator | Not recorded | In 1 condition |
| NDUFA6NADH:ubiquinone oxidoreductase subunit A6 | Not recorded | In 1 condition |
| TBPTATA-box binding protein | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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