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Trait

Abnormal shape of upper motor neuron

Clinical name: Abnormal upper motor neuron morphology

Any structural anomaly that affects the upper motor neuron.

HPO HP:0002127

Summary

Body system
Abnormality of the nervous system

16 condition reports read genes linked to this trait

Dante Labs condition reports look at the genes behind groups of inherited conditions, read from one whole-genome test. Each page says which conditions and genes a report covers, how it is read and what it cannot tell you.

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15 genes linked to Abnormal shape of upper motor neuron

Changes in these genes cause rare conditions in which Abnormal shape of upper motor neuron is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
ALS2alsin Rho guanine nucleotide exchange factor ALS2Very often (80–99%)In 3 conditions
CHCHD10coiled-coil-helix-coiled-coil-helix domain containing 10Very often (80–99%)In 1 condition
ERLIN2ER lipid raft associated 2Very often (80–99%)In 1 condition
FUSFUS RNA binding proteinVery often (80–99%)In 1 condition
SPG7SPG7 matrix AAA peptidase subunit, parapleginVery often (80–99%)In 1 condition
SQSTM1sequestosome 1Very often (80–99%)In 1 condition
TARDBPTAR DNA binding proteinVery often (80–99%)In 1 condition
TBK1TANK binding kinase 1Very often (80–99%)In 1 condition
VCPvalosin containing proteinVery often (80–99%)In 1 condition
PNPLA6patatin like domain 6, lysophospholipaseSometimes (5–29%)In 1 condition
ALDH18A1aldehyde dehydrogenase 18 family member A1Not recordedIn 1 condition
GBE11,4-alpha-glucan branching enzyme 1Not recordedIn 1 condition
MATR3matrin 3Not recordedIn 1 condition
TREM2triggering receptor expressed on myeloid cells 2Not recordedIn 1 condition
TYROBPtransmembrane immune signaling adaptor TYROBPNot recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal shape of motor neuron

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.19-9814e911.

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