Trait
Loss of bladder control
Clinical name: Urinary incontinence
Loss of the ability to control the urinary bladder leading to involuntary urination.
Summary
- Also called
- Bladder incontinence
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Loss of bladder control, and the rest of your genome, with one test.
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Get my Genome Test165 genes linked to Loss of bladder control
Changes in these genes cause rare conditions in which Loss of bladder control is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| BORCS8BLOC-1 related complex subunit 8 | Always | In 1 condition |
| CST3cystatin C | Always | In 1 condition |
| FRYLFRY like transcription coactivator | Always | In 1 condition |
| GAAalpha glucosidase | Always | In 1 condition |
| GBE11,4-alpha-glucan branching enzyme 1 | Always | In 2 conditions |
| GGT1gamma-glutamyltransferase 1 | Always | In 1 condition |
| HS6ST2heparan sulfate 6-O-sulfotransferase 2 | Always | In 1 condition |
| HTRA1HtrA serine peptidase 1 | Always | In 1 condition |
| KMT2Blysine methyltransferase 2B | Always | In 1 condition |
| KYkyphoscoliosis peptidase | Always | In 1 condition |
| NEXMIFneurite extension and migration factor | Always | In 1 condition |
| NOTCH3notch receptor 3 | Always | In 2 conditions |
| POT1protection of telomeres 1 | Always | In 1 condition |
| RSRC1arginine and serine rich coiled-coil 1 | Always | In 1 condition |
| SLC44A1solute carrier family 44 member 1 | Always | In 1 condition |
| TOP2BDNA topoisomerase II beta | Always | In 1 condition |
| ADNPactivity dependent neuroprotector homeobox | Very often (80–99%) | In 1 condition |
| RTN2reticulon 2 | Very often (80–99%) | In 2 conditions |
| ACBD6acyl-CoA binding domain containing 6 | Often (30–79%) | In 1 condition |
| ALDH18A1aldehyde dehydrogenase 18 family member A1 | Often (30–79%) | In 3 conditions |
| ALS2alsin Rho guanine nucleotide exchange factor ALS2 | Often (30–79%) | In 3 conditions |
| AP5Z1adaptor related protein complex 5 subunit zeta 1 | Often (30–79%) | In 2 conditions |
| ARSAarylsulfatase A | Often (30–79%) | In 4 conditions |
| ARXaristaless related homeobox | Often (30–79%) | In 1 condition |
| ATP13A2ATPase cation transporting 13A2 | Often (30–79%) | In 2 conditions |
| ATXN2ataxin 2 | Often (30–79%) | In 1 condition |
| COPB1coat protein complex I subunit beta 1 | Often (30–79%) | In 1 condition |
| CPT1Ccarnitine palmitoyltransferase 1C | Often (30–79%) | In 1 condition |
| CYP7B1cytochrome P450 family 7 subfamily B member 1 | Often (30–79%) | In 1 condition |
| DDHD2DDHD domain containing 2 | Often (30–79%) | In 1 condition |
| DPH5diphthamide biosynthesis 5 | Often (30–79%) | In 1 condition |
| GJC2gap junction protein gamma 2 | Often (30–79%) | In 1 condition |
| HPSE2heparanase 2 (inactive) | Often (30–79%) | In 1 condition |
| HSPD1heat shock protein family D (Hsp60) member 1 | Often (30–79%) | In 2 conditions |
| KCND3potassium voltage-gated channel subfamily D member 3 | Often (30–79%) | In 1 condition |
| LRIG2leucine rich repeats and immunoglobulin like domains 2 | Often (30–79%) | In 1 condition |
| MYO1Hmyosin IH | Often (30–79%) | In 1 condition |
| NGFnerve growth factor | Often (30–79%) | In 1 condition |
| NOTCH2NLCnotch 2 N-terminal like C | Often (30–79%) | In 1 condition |
| PPFIA3PPFI scaffold protein A3 | Often (30–79%) | In 1 condition |
Show 125 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| PSAPprosaposin | Often (30–79%) | In 4 conditions |
| SACSsacsin molecular chaperone | Often (30–79%) | In 1 condition |
| SPG7SPG7 matrix AAA peptidase subunit, paraplegin | Often (30–79%) | In 1 condition |
| SQSTM1sequestosome 1 | Often (30–79%) | In 1 condition |
| STUB1STIP1 homology and U-box containing protein 1 | Often (30–79%) | In 1 condition |
| UBAP1ubiquitin associated protein 1 | Often (30–79%) | In 1 condition |
| VPS13Cvacuolar protein sorting 13 homolog C | Often (30–79%) | In 1 condition |
| WASHC5WASH complex subunit 5 | Often (30–79%) | In 2 conditions |
| ZEB2zinc finger E-box binding homeobox 2 | Often (30–79%) | In 2 conditions |
| ABCD1ATP binding cassette subfamily D member 1 | Sometimes (5–29%) | In 2 conditions |
| ALMS1ALMS1 centrosome and basal body associated protein | Sometimes (5–29%) | In 1 condition |
| ATXN8ataxin 8 | Sometimes (5–29%) | In 1 condition |
| ATXN8OSATXN8 opposite strand lncRNA | Sometimes (5–29%) | In 1 condition |
| BIN1bridging integrator 1 | Sometimes (5–29%) | In 1 condition |
| BNC2basonuclin zinc finger protein 2 | Sometimes (5–29%) | In 2 conditions |
| CABP4calcium binding protein 4 | Sometimes (5–29%) | In 1 condition |
| CACNA1Gcalcium voltage-gated channel subunit alpha1 G | Sometimes (5–29%) | In 2 conditions |
| CAPN1calpain 1 | Sometimes (5–29%) | In 1 condition |
| CHRNA2cholinergic receptor nicotinic alpha 2 subunit | Sometimes (5–29%) | In 1 condition |
| CHRNA4cholinergic receptor nicotinic alpha 4 subunit | Sometimes (5–29%) | In 1 condition |
| CHRNB2cholinergic receptor nicotinic beta 2 subunit | Sometimes (5–29%) | In 1 condition |
| COG5component of oligomeric golgi complex 5 | Sometimes (5–29%) | In 1 condition |
| CRHcorticotropin releasing hormone | Sometimes (5–29%) | In 1 condition |
| DEPDC5DEP domain containing 5, GATOR1 subcomplex subunit | Sometimes (5–29%) | In 1 condition |
| DKK1dickkopf Wnt signaling pathway inhibitor 1 | Sometimes (5–29%) | In 1 condition |
| DNM2dynamin 2 | Sometimes (5–29%) | In 1 condition |
| DNMT1DNA methyltransferase 1 | Sometimes (5–29%) | In 1 condition |
| EIF2AK2eukaryotic translation initiation factor 2 alpha kinase 2 | Sometimes (5–29%) | In 1 condition |
| ERLIN1ER lipid raft associated 1 | Sometimes (5–29%) | In 1 condition |
| FA2Hfatty acid 2-hydroxylase | Sometimes (5–29%) | In 2 conditions |
| FARS2phenylalanyl-tRNA synthetase 2, mitochondrial | Sometimes (5–29%) | In 1 condition |
| FGFR3fibroblast growth factor receptor 3 | Sometimes (5–29%) | In 1 condition |
| FITM2fat storage inducing transmembrane protein 2 | Sometimes (5–29%) | In 1 condition |
| FRMD5FERM domain containing 5 | Sometimes (5–29%) | In 1 condition |
| FUSFUS RNA binding protein | Sometimes (5–29%) | In 1 condition |
| GBA2glucosylceramidase beta 2 | Sometimes (5–29%) | In 3 conditions |
| GNEglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | Sometimes (5–29%) | In 1 condition |
| HACE1HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 | Sometimes (5–29%) | In 1 condition |
| HEXBhexosaminidase subunit beta | Sometimes (5–29%) | In 2 conditions |
| HPS6HPS6 biogenesis of lysosomal organelles complex 2 subunit 3 | Sometimes (5–29%) | In 1 condition |
| KCNC3potassium voltage-gated channel subfamily C member 3 | Sometimes (5–29%) | In 1 condition |
| KCNT1potassium sodium-activated channel subfamily T member 1 | Sometimes (5–29%) | In 1 condition |
| MORC2MORC family CW-type zinc finger 2 | Sometimes (5–29%) | In 2 conditions |
| MTMR14myotubularin related protein 14 | Sometimes (5–29%) | In 1 condition |
| MYF6myogenic factor 6 | Sometimes (5–29%) | In 1 condition |
| NEFLneurofilament light chain | Sometimes (5–29%) | In 1 condition |
| NIPA1NIPA magnesium transporter 1 | Sometimes (5–29%) | In 2 conditions |
| RNF170ring finger protein 170 | Sometimes (5–29%) | In 1 condition |
| RYR1ryanodine receptor 1 | Sometimes (5–29%) | In 1 condition |
| SBF1SET binding factor 1 | Sometimes (5–29%) | In 1 condition |
| SIGMAR1sigma receptor chaperone 1 | Sometimes (5–29%) | In 1 condition |
| SLC1A4solute carrier family 1 member 4 | Sometimes (5–29%) | In 1 condition |
| SORDsorbitol dehydrogenase | Sometimes (5–29%) | In 1 condition |
| SPG11SPG11 vesicle trafficking associated, spatacsin | Sometimes (5–29%) | In 3 conditions |
| SPTLC1serine palmitoyltransferase long chain base subunit 1 | Sometimes (5–29%) | In 1 condition |
| SPTLC2serine palmitoyltransferase long chain base subunit 2 | Sometimes (5–29%) | In 1 condition |
| SYNE1spectrin repeat containing nuclear envelope protein 1 | Sometimes (5–29%) | In 2 conditions |
| TARDBPTAR DNA binding protein | Sometimes (5–29%) | In 1 condition |
| TBCDtubulin folding cofactor D | Sometimes (5–29%) | In 2 conditions |
| TIMM50translocase of inner mitochondrial membrane 50 | Sometimes (5–29%) | In 2 conditions |
| TRIOtrio Rho guanine nucleotide exchange factor | Sometimes (5–29%) | In 1 condition |
| TRMT2BtRNA methyltransferase 2B | Sometimes (5–29%) | In 1 condition |
| UBQLN2ubiquilin 2 | Sometimes (5–29%) | In 1 condition |
| VCPvalosin containing protein | Sometimes (5–29%) | In 1 condition |
| ZMYM2zinc finger MYM-type containing 2 | Sometimes (5–29%) | In 1 condition |
| AKT1AKT serine/threonine kinase 1 | Rarely (1–4%) | In 1 condition |
| ALDH3A2aldehyde dehydrogenase 3 family member A2 | Rarely (1–4%) | In 1 condition |
| BAP1BRCA1 associated deubiquitinase 1 | Rarely (1–4%) | In 1 condition |
| CACNA1Hcalcium voltage-gated channel subunit alpha1 H | Rarely (1–4%) | In 1 condition |
| CLCNKBchloride voltage-gated channel Kb | Rarely (1–4%) | In 1 condition |
| GABRA1gamma-aminobutyric acid type A receptor subunit alpha1 | Rarely (1–4%) | In 1 condition |
| GABRB3gamma-aminobutyric acid type A receptor subunit beta3 | Rarely (1–4%) | In 1 condition |
| GABRG2gamma-aminobutyric acid type A receptor subunit gamma2 | Rarely (1–4%) | In 1 condition |
| GALCgalactosylceramidase | Rarely (1–4%) | In 1 condition |
| HMBShydroxymethylbilane synthase | Rarely (1–4%) | In 2 conditions |
| JRKJrk helix-turn-helix protein | Rarely (1–4%) | In 1 condition |
| NF2NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor | Rarely (1–4%) | In 1 condition |
| PDGFBplatelet derived growth factor subunit B | Rarely (1–4%) | In 2 conditions |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Rarely (1–4%) | In 1 condition |
| SLC12A3solute carrier family 12 member 3 | Rarely (1–4%) | In 1 condition |
| SMARCB1SWI/SNF related BAF chromatin remodeling complex subunit B1 | Rarely (1–4%) | In 1 condition |
| SMARCE1SWI/SNF related BAF chromatin remodeling complex subunit E1 | Rarely (1–4%) | In 1 condition |
| SMOsmoothened, frizzled class receptor | Rarely (1–4%) | In 1 condition |
| SUFUSUFU negative regulator of hedgehog signaling | Rarely (1–4%) | In 1 condition |
| TERTtelomerase reverse transcriptase | Rarely (1–4%) | In 1 condition |
| TRAF7TNF receptor associated factor 7 | Rarely (1–4%) | In 1 condition |
| ATL1atlastin GTPase 1 | Not recorded | In 1 condition |
| ATXN10ataxin 10 | Not recorded | In 1 condition |
| AUHAU RNA binding methylglutaconyl-CoA hydratase | Not recorded | In 1 condition |
| CFAP43cilia and flagella associated protein 43 | Not recorded | In 1 condition |
| CHMP2Bcharged multivesicular body protein 2B | Not recorded | In 1 condition |
| COQ2coenzyme Q2, polyprenyltransferase | Not recorded | In 1 condition |
| FLVCR1FLVCR choline and heme transporter 1 | Not recorded | In 1 condition |
| FMR1fragile X messenger ribonucleoprotein 1 | Not recorded | In 1 condition |
| FUZfuzzy planar cell polarity protein | Not recorded | In 1 condition |
| GALNT2polypeptide N-acetylgalactosaminyltransferase 2 | Not recorded | In 1 condition |
| HLA-DQB1major histocompatibility complex, class II, DQ beta 1 | Not recorded | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Not recorded | In 1 condition |
| IFT57intraflagellar transport 57 | Not recorded | In 1 condition |
| IGHMBP2immunoglobulin mu DNA binding protein 2 | Not recorded | In 1 condition |
| JAM2junctional adhesion molecule 2 | Not recorded | In 1 condition |
| KIF5Akinesin family member 5A | Not recorded | In 1 condition |
| MNX1motor neuron and pancreas homeobox 1 | Not recorded | In 1 condition |
| MYORGmyogenesis regulating glycosidase | Not recorded | In 1 condition |
| NAA60N-alpha-acetyltransferase 60, NatF catalytic subunit | Not recorded | In 1 condition |
| PANK2pantothenate kinase 2 | Not recorded | In 1 condition |
| PDGFRBplatelet derived growth factor receptor beta | Not recorded | In 1 condition |
| PEX11Bperoxisomal biogenesis factor 11 beta | Not recorded | In 1 condition |
| PRDM8PR/SET domain 8 | Not recorded | In 1 condition |
| RETREG1reticulophagy regulator 1 | Not recorded | In 1 condition |
| SCN9Asodium voltage-gated channel alpha subunit 9 | Not recorded | In 1 condition |
| SLC20A2solute carrier family 20 member 2 | Not recorded | In 1 condition |
| SLC9A6solute carrier family 9 member A6 | Not recorded | In 1 condition |
| SPASTspastin | Not recorded | In 1 condition |
| TBPTATA-box binding protein | Not recorded | In 1 condition |
| TBXTT-box transcription factor T | Not recorded | In 1 condition |
| TREM2triggering receptor expressed on myeloid cells 2 | Not recorded | In 1 condition |
| TRPV4transient receptor potential cation channel subfamily V member 4 | Not recorded | In 1 condition |
| TTRtransthyretin | Not recorded | In 1 condition |
| TYROBPtransmembrane immune signaling adaptor TYROBP | Not recorded | In 1 condition |
| VANGL1VANGL planar cell polarity protein 1 | Not recorded | In 1 condition |
| VANGL2VANGL planar cell polarity protein 2 | Not recorded | In 1 condition |
| XPR1xenotropic and polytropic retrovirus receptor 1 | Not recorded | In 1 condition |
| ZC4H2zinc finger C4H2-type containing | Not recorded | In 1 condition |
| ZFYVE26zinc finger FYVE-type containing 26 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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