Trait
Broad forehead
Width of the forehead or distance between the frontotemporales is more than two standard deviations above the mean (objective); or apparently increased distance between the two sides of the forehead.
Summary
- Also called
- Increased width of the forehead, Wide forehead, Bitemporal widening, Increased bitemporal dimension, Increased bitemporal width, Intertemporal widening
- Body system
- Abnormality of head or neck
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test224 genes linked to Broad forehead
Changes in these genes cause rare conditions in which Broad forehead is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ALDH18A1aldehyde dehydrogenase 18 family member A1 | Always | In 2 conditions |
| ALPK3alpha kinase 3 | Always | In 1 condition |
| AMOTL1angiomotin like 1 | Always | In 1 condition |
| ANKHANKH inorganic pyrophosphate transport regulator | Always | In 1 condition |
| ANTXR1ANTXR cell adhesion molecule 1 | Always | In 2 conditions |
| BUD13BUD13 spliceosome associated protein | Always | In 1 condition |
| CCDC22CCC complex scaffolding subunit CCDC22 | Always | In 1 condition |
| CHD8chromodomain helicase DNA binding protein 8 | Always | In 1 condition |
| DMRT2doublesex and mab-3 related transcription factor 2 | Always | In 1 condition |
| EMC10ER membrane protein complex subunit 10 | Always | In 1 condition |
| ESAMendothelial cell adhesion molecule | Always | In 1 condition |
| FBN1fibrillin 1 | Always | In 1 condition |
| IFIH1interferon induced with helicase C domain 1 | Always | In 1 condition |
| IGBP1immunoglobulin binding protein 1 | Always | In 1 condition |
| INPP4Ainositol polyphosphate-4-phosphatase type I A | Always | In 1 condition |
| JAG1jagged canonical Notch ligand 1 | Always | In 3 conditions |
| KDM6Blysine demethylase 6B | Always | In 1 condition |
| MKS1MKS transition zone complex subunit 1 | Always | In 2 conditions |
| NSD1nuclear receptor binding SET domain protein 1 | Always | In 2 conditions |
| PIGAphosphatidylinositol glycan anchor biosynthesis class A | Always | In 1 condition |
| POLR1ARNA polymerase I subunit A | Always | In 1 condition |
| PSMD12proteasome 26S subunit, non-ATPase 12 | Always | In 1 condition |
| PTDSS1phosphatidylserine synthase 1 | Always | In 2 conditions |
| PYCR1pyrroline-5-carboxylate reductase 1 | Always | In 1 condition |
| RLIMring finger protein, LIM domain interacting | Always | In 1 condition |
| ROBO1roundabout guidance receptor 1 | Always | In 1 condition |
| SATB2SATB homeobox 2 | Always | In 1 condition |
| SHOC2SHOC2 leucine rich repeat scaffold protein | Always | In 1 condition |
| SKIC3SKI3 subunit of superkiller complex | Always | In 2 conditions |
| SLC25A24solute carrier family 25 member 24 | Always | In 2 conditions |
| TAFAZZINtafazzin, phospholipid-lysophospholipid transacylase | Always | In 2 conditions |
| TBC1D32TBC1 domain family member 32 | Always | In 1 condition |
| TBC1D7TBC1 domain family member 7 | Always | In 1 condition |
| TOMM7translocase of outer mitochondrial membrane 7 | Always | In 1 condition |
| UBAP2Lubiquitin associated protein 2 like | Always | In 1 condition |
| UNC13Aunc-13 homolog A | Always | In 1 condition |
| WASHC5WASH complex subunit 5 | Always | In 1 condition |
| YY1YY1 transcription factor | Always | In 2 conditions |
| AIPAHR interacting HSP90 co-chaperone | Very often (80–99%) | In 1 condition |
| B4GALT7beta-1,4-galactosyltransferase 7 | Very often (80–99%) | In 1 condition |
Show 184 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| BAZ1Bbromodomain adjacent to zinc finger domain 1B | Very often (80–99%) | In 1 condition |
| BUD23BUD23 rRNA methyltransferase and ribosome maturation factor | Very often (80–99%) | In 1 condition |
| CAMTA1calmodulin binding transcription activator 1 | Very often (80–99%) | In 1 condition |
| CCDC8coiled-coil domain containing 8 subunit of 3M complex | Very often (80–99%) | In 1 condition |
| CITED2Cbp/p300 interacting transactivator with ED-rich tail 2 | Very often (80–99%) | In 1 condition |
| CLIP2CAP-Gly domain containing linker protein 2 | Very often (80–99%) | In 1 condition |
| CUL7cullin 7 | Very often (80–99%) | In 1 condition |
| DNAJC30DnaJ heat shock protein family (Hsp40) member C30 | Very often (80–99%) | In 1 condition |
| EIF4Heukaryotic translation initiation factor 4H | Very often (80–99%) | In 1 condition |
| ELNelastin | Very often (80–99%) | In 2 conditions |
| EZH2enhancer of zeste 2 polycomb repressive complex 2 subunit | Very often (80–99%) | In 1 condition |
| FGFR2fibroblast growth factor receptor 2 | Very often (80–99%) | In 3 conditions |
| FGFR3fibroblast growth factor receptor 3 | Very often (80–99%) | In 1 condition |
| FKBP6FKBP prolyl isomerase family member 6 (inactive) | Very often (80–99%) | In 1 condition |
| FLNAfilamin A | Very often (80–99%) | In 1 condition |
| FLT4fms related receptor tyrosine kinase 4 | Very often (80–99%) | In 1 condition |
| GATA4GATA binding protein 4 | Very often (80–99%) | In 2 conditions |
| GATA5GATA binding protein 5 | Very often (80–99%) | In 1 condition |
| GATA6GATA binding protein 6 | Very often (80–99%) | In 2 conditions |
| GDF1growth differentiation factor 1 | Very often (80–99%) | In 1 condition |
| GJA5gap junction protein alpha 5 | Very often (80–99%) | In 1 condition |
| GPC3glypican 3 | Very often (80–99%) | In 1 condition |
| GPC4glypican 4 | Very often (80–99%) | In 1 condition |
| GPR101G protein-coupled receptor 101 | Very often (80–99%) | In 1 condition |
| GTF2Igeneral transcription factor IIi | Very often (80–99%) | In 1 condition |
| GTF2IRD1GTF2I repeat domain containing 1 | Very often (80–99%) | In 1 condition |
| GTF2IRD2GTF2I repeat domain containing 2 | Very often (80–99%) | In 1 condition |
| KDRkinase insert domain receptor | Very often (80–99%) | In 1 condition |
| LIMK1LIM domain kinase 1 | Very often (80–99%) | In 1 condition |
| LRP5LDL receptor related protein 5 | Very often (80–99%) | In 1 condition |
| MEF2Cmyocyte enhancer factor 2C | Very often (80–99%) | In 2 conditions |
| METTL27methyltransferase like 27 | Very often (80–99%) | In 1 condition |
| NCF1neutrophil cytosolic factor 1 | Very often (80–99%) | In 1 condition |
| NKX2-5NK2 homeobox 5 | Very often (80–99%) | In 2 conditions |
| NKX2-6NK2 homeobox 6 | Very often (80–99%) | In 1 condition |
| OBSL1obscurin like cytoskeletal adaptor 1 | Very often (80–99%) | In 1 condition |
| PIGNphosphatidylinositol glycan anchor biosynthesis class N | Very often (80–99%) | In 1 condition |
| POLR3ARNA polymerase III subunit A | Very often (80–99%) | In 1 condition |
| RAI1retinoic acid induced 1 | Very often (80–99%) | In 3 conditions |
| RFC2replication factor C subunit 2 | Very often (80–99%) | In 1 condition |
| RNF135ring finger protein 135 | Very often (80–99%) | In 1 condition |
| SETBP1SET binding protein 1 | Very often (80–99%) | In 1 condition |
| STX1Asyntaxin 1A | Very often (80–99%) | In 1 condition |
| SUZ12SUZ12 polycomb repressive complex 2 subunit | Very often (80–99%) | In 1 condition |
| TBL2transducin beta like 2 | Very often (80–99%) | In 1 condition |
| TBX1T-box transcription factor 1 | Very often (80–99%) | In 2 conditions |
| TCF12transcription factor 12 | Very often (80–99%) | In 1 condition |
| TMEM270transmembrane protein 270 | Very often (80–99%) | In 1 condition |
| TWIST1twist family bHLH transcription factor 1 | Very often (80–99%) | In 1 condition |
| VPS37DVPS37D subunit of ESCRT-I | Very often (80–99%) | In 1 condition |
| ZBTB20zinc finger and BTB domain containing 20 | Very often (80–99%) | In 1 condition |
| ZFPM2zinc finger protein, FOG family member 2 | Very often (80–99%) | In 2 conditions |
| ZIC1Zic family zinc finger 1 | Very often (80–99%) | In 1 condition |
| ACTL6Bactin like 6B | Often (30–79%) | In 1 condition |
| ADAMTS3ADAM metallopeptidase with thrombospondin type 1 motif 3 | Often (30–79%) | In 1 condition |
| AHDC1AT-hook DNA binding motif containing 1 | Often (30–79%) | In 1 condition |
| B3GAT3beta-1,3-glucuronyltransferase 3 | Often (30–79%) | In 1 condition |
| BMP1bone morphogenetic protein 1 | Often (30–79%) | In 1 condition |
| BMP2bone morphogenetic protein 2 | Often (30–79%) | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Often (30–79%) | In 1 condition |
| CASKcalcium/calmodulin dependent serine protein kinase | Often (30–79%) | In 1 condition |
| CBLCbl proto-oncogene | Often (30–79%) | In 1 condition |
| CCBE1collagen and calcium binding EGF domains 1 | Often (30–79%) | In 2 conditions |
| CDH11cadherin 11 | Often (30–79%) | In 1 condition |
| CDKL5cyclin dependent kinase like 5 | Often (30–79%) | In 2 conditions |
| CHST3carbohydrate sulfotransferase 3 | Often (30–79%) | In 3 conditions |
| CKAP2Lcytoskeleton associated protein 2L | Often (30–79%) | In 2 conditions |
| DPH5diphthamide biosynthesis 5 | Often (30–79%) | In 1 condition |
| FAT4FAT atypical cadherin 4 | Often (30–79%) | In 1 condition |
| FGD1FYVE, RhoGEF and PH domain containing 1 | Often (30–79%) | In 1 condition |
| FUT8fucosyltransferase 8 | Often (30–79%) | In 1 condition |
| GATAD2BGATA zinc finger domain containing 2B | Often (30–79%) | In 2 conditions |
| HBA1hemoglobin subunit alpha 1 | Often (30–79%) | In 1 condition |
| HBA2hemoglobin subunit alpha 2 | Often (30–79%) | In 1 condition |
| HOXB1homeobox B1 | Often (30–79%) | In 1 condition |
| KANSL1KAT8 regulatory NSL complex subunit 1 | Often (30–79%) | In 1 condition |
| KIF7kinesin family member 7 | Often (30–79%) | In 1 condition |
| LRP2LDL receptor related protein 2 | Often (30–79%) | In 1 condition |
| MAP2K1mitogen-activated protein kinase kinase 1 | Often (30–79%) | In 1 condition |
| MBD5methyl-CpG binding domain protein 5 | Often (30–79%) | In 2 conditions |
| NFIXnuclear factor I X | Often (30–79%) | In 1 condition |
| NRASNRAS proto-oncogene, GTPase | Often (30–79%) | In 2 conditions |
| PAN2poly(A) specific ribonuclease subunit PAN2 | Often (30–79%) | In 1 condition |
| POGZpogo transposable element derived with ZNF domain | Often (30–79%) | In 1 condition |
| POLEDNA polymerase epsilon, catalytic subunit | Often (30–79%) | In 1 condition |
| PPM1Dprotein phosphatase, Mg2+/Mn2+ dependent 1D | Often (30–79%) | In 1 condition |
| PRIM1DNA primase subunit 1 | Often (30–79%) | In 1 condition |
| PTBP1polypyrimidine tract binding protein 1 | Often (30–79%) | In 1 condition |
| PTPN11protein tyrosine phosphatase non-receptor type 11 | Often (30–79%) | In 1 condition |
| RBM8ARNA binding motif protein 8A | Often (30–79%) | In 1 condition |
| RYR3ryanodine receptor 3 | Often (30–79%) | In 1 condition |
| SH3PXD2BSH3 and PX domains 2B | Often (30–79%) | In 1 condition |
| SIN3ASIN3 transcription regulator family member A | Often (30–79%) | In 1 condition |
| SKIC2SKI2 subunit of superkiller complex | Often (30–79%) | In 1 condition |
| SMAD2SMAD family member 2 | Often (30–79%) | In 1 condition |
| STEEP1STING1 ER exit protein 1 | Often (30–79%) | In 1 condition |
| TCEAL1transcription elongation factor A like 1 | Often (30–79%) | In 1 condition |
| TRPM3transient receptor potential cation channel subfamily M member 3 | Often (30–79%) | In 1 condition |
| ZRSR2zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2 | Often (30–79%) | In 1 condition |
| ACTG2actin gamma 2, smooth muscle | Sometimes (5–29%) | In 1 condition |
| CDC42BPBCDC42 binding protein kinase beta | Sometimes (5–29%) | In 1 condition |
| CDH2cadherin 2 | Sometimes (5–29%) | In 1 condition |
| CUX1cut like homeobox 1 | Sometimes (5–29%) | In 1 condition |
| DLK1delta like non-canonical Notch ligand 1 | Sometimes (5–29%) | In 1 condition |
| DLL3delta like canonical Notch ligand 3 | Sometimes (5–29%) | In 1 condition |
| DPP9dipeptidyl peptidase 9 | Sometimes (5–29%) | In 1 condition |
| EBF3EBF transcription factor 3 | Sometimes (5–29%) | In 2 conditions |
| FBLN5fibulin 5 | Sometimes (5–29%) | In 1 condition |
| FBXO11F-box protein 11 | Sometimes (5–29%) | In 1 condition |
| HECTD4HECT domain E3 ubiquitin protein ligase 4 | Sometimes (5–29%) | In 1 condition |
| HES7hes family bHLH transcription factor 7 | Sometimes (5–29%) | In 1 condition |
| HIVEP2HIVEP zinc finger 2 | Sometimes (5–29%) | In 1 condition |
| IDH1isocitrate dehydrogenase (NADP(+)) 1 | Sometimes (5–29%) | In 1 condition |
| JARID2jumonji and AT-rich interaction domain containing 2 | Sometimes (5–29%) | In 1 condition |
| KCNH1potassium voltage-gated channel subfamily H member 1 | Sometimes (5–29%) | In 1 condition |
| KCNJ2potassium inwardly rectifying channel subfamily J member 2 | Sometimes (5–29%) | In 2 conditions |
| KCNJ5potassium inwardly rectifying channel subfamily J member 5 | Sometimes (5–29%) | In 1 condition |
| KDM2Blysine demethylase 2B | Sometimes (5–29%) | In 1 condition |
| LFNGLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | Sometimes (5–29%) | In 1 condition |
| MADDMAP kinase activating death domain | Sometimes (5–29%) | In 1 condition |
| MAN2B1mannosidase alpha class 2B member 1 | Sometimes (5–29%) | In 2 conditions |
| MARK2microtubule affinity regulating kinase 2 | Sometimes (5–29%) | In 1 condition |
| MED13Lmediator complex subunit 13L | Sometimes (5–29%) | In 1 condition |
| MEG3maternally expressed 3 | Sometimes (5–29%) | In 1 condition |
| MESP2mesoderm posterior bHLH transcription factor 2 | Sometimes (5–29%) | In 1 condition |
| NAA10N-alpha-acetyltransferase 10, NatA catalytic subunit | Sometimes (5–29%) | In 1 condition |
| NALCNsodium leak channel, non-selective | Sometimes (5–29%) | In 1 condition |
| NARS1asparaginyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| NF1neurofibromin 1 | Sometimes (5–29%) | In 1 condition |
| NIPA1NIPA magnesium transporter 1 | Sometimes (5–29%) | In 1 condition |
| NIPA2NIPA magnesium transporter 2 | Sometimes (5–29%) | In 1 condition |
| ODC1ornithine decarboxylase 1 | Sometimes (5–29%) | In 1 condition |
| PIGUphosphatidylinositol glycan anchor biosynthesis class U | Sometimes (5–29%) | In 1 condition |
| PPP2CAprotein phosphatase 2 catalytic subunit alpha | Sometimes (5–29%) | In 1 condition |
| PRKACBprotein kinase cAMP-activated catalytic subunit beta | Sometimes (5–29%) | In 1 condition |
| PSPHphosphoserine phosphatase | Sometimes (5–29%) | In 1 condition |
| RAB34RAB34, member RAS oncogene family | Sometimes (5–29%) | In 1 condition |
| RECQL4RecQ like helicase 4 | Sometimes (5–29%) | In 1 condition |
| RIPPLY2ripply transcriptional repressor 2 | Sometimes (5–29%) | In 1 condition |
| RPL10ribosomal protein L10 | Sometimes (5–29%) | In 1 condition |
| RTL1retrotransposon Gag like 1 | Sometimes (5–29%) | In 1 condition |
| RUNX2RUNX family transcription factor 2 | Sometimes (5–29%) | In 1 condition |
| SCNM1sodium channel modifier 1 | Sometimes (5–29%) | In 1 condition |
| SH2B1SH2B adaptor protein 1 | Sometimes (5–29%) | In 1 condition |
| SIM1SIM bHLH transcription factor 1 | Sometimes (5–29%) | In 1 condition |
| SLC26A2solute carrier family 26 member 2 | Sometimes (5–29%) | In 1 condition |
| TBCBtubulin folding cofactor B | Sometimes (5–29%) | In 1 condition |
| TBCKTBC1 domain containing kinase | Sometimes (5–29%) | In 2 conditions |
| TBX6T-box transcription factor 6 | Sometimes (5–29%) | In 1 condition |
| TCTN2tectonic family member 2 | Sometimes (5–29%) | In 1 condition |
| THOC2THO complex subunit 2 | Sometimes (5–29%) | In 1 condition |
| THOC6THO complex subunit 6 | Sometimes (5–29%) | In 1 condition |
| TTC5tetratricopeptide repeat domain 5 | Sometimes (5–29%) | In 1 condition |
| TUBG1tubulin gamma 1 | Sometimes (5–29%) | In 1 condition |
| WACWW domain containing adaptor with coiled-coil | Sometimes (5–29%) | In 2 conditions |
| WBP11WW domain binding protein 11 | Sometimes (5–29%) | In 1 condition |
| WDR83OSWD repeat domain 83 opposite strand | Sometimes (5–29%) | In 1 condition |
| ZFXzinc finger protein X-linked | Sometimes (5–29%) | In 1 condition |
| ZIC2Zic family zinc finger 2 | Sometimes (5–29%) | In 1 condition |
| CNTNAP2contactin associated protein 2 | Rarely (1–4%) | In 1 condition |
| SPTBN1spectrin beta, non-erythrocytic 1 | Rarely (1–4%) | In 1 condition |
| ABL1ABL proto-oncogene 1, non-receptor tyrosine kinase | Not recorded | In 1 condition |
| AMMECR1AMMECR nuclear protein 1 | Not recorded | In 1 condition |
| CCNQcyclin Q | Not recorded | In 1 condition |
| CHST14carbohydrate sulfotransferase 14 | Not recorded | In 1 condition |
| COLEC11collectin subfamily member 11 | Not recorded | In 1 condition |
| DNMT3ADNA methyltransferase 3 alpha | Not recorded | In 1 condition |
| EEDembryonic ectoderm development | Not recorded | In 1 condition |
| FLCNfolliculin | Not recorded | In 1 condition |
| HRASHRas proto-oncogene, GTPase | Not recorded | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Not recorded | In 1 condition |
| NFIAnuclear factor I A | Not recorded | In 1 condition |
| NOTCH2notch receptor 2 | Not recorded | In 1 condition |
| PAK1p21 (RAC1) activated kinase 1 | Not recorded | In 1 condition |
| PCGF2polycomb group ring finger 2 | Not recorded | In 1 condition |
| PEX3peroxisomal biogenesis factor 3 | Not recorded | In 1 condition |
| PIGBphosphatidylinositol glycan anchor biosynthesis class B | Not recorded | In 1 condition |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Not recorded | In 1 condition |
| PTENphosphatase and tensin homolog | Not recorded | In 1 condition |
| SLC6A8solute carrier family 6 member 8 | Not recorded | In 1 condition |
| TENT5Aterminal nucleotidyltransferase 5A | Not recorded | In 1 condition |
| TET3tet methylcytosine dioxygenase 3 | Not recorded | In 1 condition |
| TFAP2Btranscription factor AP-2 beta | Not recorded | In 1 condition |
| UNC80unc-80 subunit of NALCN channel complex | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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