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Gene

DPP9

dipeptidyl peptidase 9

Summary

Cytogenetic location
19p13.3
Coordinates
Chromosome 19: 4,675,227–4,723,842 (GRCh38)
Exons
22 exons across 48.6 kb
Protein
892 amino acids
MANE Select transcript
ENST00000262960.14NM_139159.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Other Inborn Errors of Immunity

      • Immunodeficiency Disease

        One of 170 genes linked to it

        Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.

        • 1 GenCC submitter rates it definitive or strong
        What knowing changes

        HSCT for SCID and severe PIDs; immunoglobulin replacement (IVIG/SCIG) for antibody deficiencies; leniolisib (Joenja, FDA 2023) for APDS; gene therapy for ADA-SCID; abatacept for CTLA4/LRBA deficiency; prophylactic antibiotics; G-CSF for CGD

    How DPP9 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 19, with a bracket where DPP9 sits. DPP9 and 26 genes near it on chromosome 19, from 4,199,535 to 5,199,534.Chromosome 1919p13.3p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.434.2 Mb4.4 Mb4.6 Mb4.8 Mb5 MbANKRD24: 4,182,630–4,224,818, forward strandANKRD24EBI3: 4,229,267–4,238,167, forward strandEBI3YJU2: 4,247,062–4,269,091, forward strandYJU2SHD: 4,279,013–4,290,728, forward strandSHDTMIGD2: 4,292,227–4,302,431, reverse strandTMIGD2FSD1: 4,304,587–4,323,844, forward strandFSD1STAP2: 4,324,040–4,342,786, reverse strandSTAP2MPND: 4,343,527–4,360,086, forward strandMPNDSH3GL1: 4,360,367–4,400,573, reverse strandSH3GL1CHAF1A: 4,402,522–4,445,018, forward strandCHAF1AUBXN6: 4,444,999–4,457,794, reverse strandUBXN6HDGFL2: 4,472,244–4,502,225, forward strandHDGFL2PLIN4: 4,502,182–4,520,379, reverse strandPLIN5: 4,522,527–4,535,285, reverse strandPLIN5: 4,528,427–4,540,067, reverse strandLRG1: 4,536,402–4,540,104, reverse strandLRG1SEMA6B: 4,542,588–4,581,795, reverse strandSEMA6BTIPE1: 4,639,503–4,655,568, forward strandTIPE1MYDGF: 4,641,374–4,670,403, reverse strandMYDGFDPP9: 4,675,227–4,723,842, reverse strandDPP9FEM1A: 4,791,734–4,801,273, forward strandFEM1ATICAM1: 4,815,932–4,831,749, reverse strandTICAM1PLIN3: 4,838,334–4,867,717, reverse strandPLIN3ARRDC5: 4,890,437–4,902,948, reverse strandARRDC5UHRF1: 4,903,080–4,962,154, forward strandUHRF1KDM4B: 4,969,106–5,153,611, forward strandKDM4BPTPRS: 5,158,495–5,340,941, reverse strandPTPRSDiagram of DPP9: 22 exons on the reverse strand of chromosome 19Exon 21: 1 known disease-causing siteExon 22: 4,675,227–4,676,656, 1,430 basesExon 21: 4,679,835–4,679,946, 112 basesExon 20: 4,682,696–4,682,838, 143 basesExon 19: 4,683,477–4,683,629, 153 basesExon 18: 4,684,663–4,684,809, 147 basesExon 17: 4,685,626–4,685,771, 146 basesExon 16: 4,688,757–4,688,892, 136 basesExon 15: 4,689,570–4,689,722, 153 basesExon 14: 4,690,878–4,690,957, 80 basesExon 13: 4,694,661–4,694,823, 163 basesExon 12: 4,695,378–4,695,555, 178 basesExon 11: 4,697,551–4,697,651, 101 basesExon 10: 4,700,216–4,700,277, 62 basesExon 9: 4,702,027–4,702,155, 129 basesExon 8: 4,702,603–4,702,716, 114 basesExon 7: 4,703,886–4,704,054, 169 basesExon 6: 4,704,131–4,704,304, 174 basesExon 5: 4,705,858–4,705,970, 113 basesExon 4: 4,714,081–4,714,337, 257 basesExon 3: 4,719,851–4,719,941, 91 basesExon 2: 4,722,499–4,722,551, 53 basesExon 1: 4,723,674–4,723,842, 169 bases22201816141210864215′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 4.3 kb of the gene's 48.6 kb; 2,679 of those bases code for the protein.

    How a genome test reads DPP9

    1

    position in DPP9 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 48.6 kb of DPP9, introns included, not only the 4.3 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). DPP9 gene: dipeptidyl peptidase 9. Retrieved 16 October 2026, from https://dantelabs.com/genes/dpp9

    Vancouver

    Dante Labs. DPP9 gene: dipeptidyl peptidase 9 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/dpp9

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