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Gene

AIP

AHR interacting HSP90 co-chaperone

Summary

Cytogenetic location
11q13.2
Coordinates
Chromosome 11: 67,483,026–67,491,103 (GRCh38)
Exons
6 exons across 8.1 kb
Protein
330 amino acids
Also known as
XAP2, ARA9, FKBP16, FKBP37
MANE Select transcript
ENST00000279146.8NM_003977.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Familial Isolated Pituitary Adenoma (FIPA / X-LAG)

    • Familial isolated pituitary adenoma

      Pituitary adenomas occurring in two or more relatives without other endocrine tumour syndromes, including AIP-related disease and X-linked acrogigantism (GPR101).

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Carriers and relatives can be offered IGF-1 testing and pituitary imaging so tumours are found early.

How AIP is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 11, with a bracket where AIP sits. AIP and 28 genes near it on chromosome 11, from 66,987,065 to 67,987,064.Chromosome 1111q13.2p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q2567 Mb67.2 Mb67.4 Mb67.6 Mb67.8 MbSYT12: 67,006,772–67,051,110, forward strandSYT12RHOD: 67,056,608–67,072,044, forward strandRHODKDM2A: 67,119,247–67,258,082, forward strandKDM2AGRK2: 67,266,351–67,286,562, forward strandGRK2ANKRD13D: 67,288,655–67,302,486, forward strandANKRD13DSSH3: 67,303,478–67,312,608, forward strandSSH3RAD9A: 67,317,871–67,398,412, forward strandRAD9APOLD4: 67,345,400–67,356,972, reverse strandPOLD4: 67,351,572–67,373,584, reverse strandCLCF1: 67,364,168–67,374,301, reverse strandCLCF1PPP1CA: 67,398,176–67,421,183, reverse strandTBC1D10C: 67,398,454–67,410,092, forward strandCARNS1: 67,414,968–67,425,613, forward strandRPS6KB2: 67,428,442–67,435,414, forward strandCORO1B: 67,435,510–67,443,828, reverse strandCORO1BPTPRCAP: 67,435,510–67,437,682, reverse strandGPR152: 67,451,301–67,452,729, reverse strandCABP4: 67,452,406–67,461,752, forward strandTMEM134: 67,461,710–67,469,291, reverse strandTMEM134AIP: 67,483,026–67,491,103, forward strandAIPPITPNM1: 67,491,075–67,506,263, reverse strandPITPNM1CDK2AP2: 67,506,490–67,508,701, reverse strandCDK2AP2CABP2: 67,518,912–67,524,517, reverse strandGSTP1: 67,583,523–67,592,110, forward strandGSTP1NDUFV1: 67,605,653–67,612,554, forward strandNDUFV1NUDT8: 67,627,937–67,630,112, reverse strandNUDT8TBX10: 67,631,303–67,639,767, reverse strandTBX10ACY3: 67,642,551–67,650,900, reverse strandACY3ALDH3B2: 67,662,155–67,681,224, reverse strandDiagram of AIP: 6 exons on the forward strand of chromosome 11Exon 1: 5 known disease-causing sitesExon 2: 5 known disease-causing sitesExon 3: 8 known disease-causing sitesExon 4: 7 known disease-causing sitesExon 5: 6 known disease-causing sitesExon 6: 9 known disease-causing sitesExon 1: 67,483,026–67,483,257, 232 basesExon 2: 67,487,006–67,487,185, 180 basesExon 3: 67,489,267–67,489,455, 189 basesExon 4: 67,490,038–67,490,214, 177 basesExon 5: 67,490,316–67,490,457, 142 basesExon 6: 67,490,788–67,491,103, 316 bases1234565′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.2 kb of the gene's 8.1 kb; 993 of those bases code for the protein.

How a genome test reads AIP

43

positions in AIP where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 8.1 kb of AIP, introns included, not only the 1.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). AIP gene: AHR interacting HSP90 co-chaperone. Retrieved 16 October 2026, from https://dantelabs.com/genes/aip

Vancouver

Dante Labs. AIP gene: AHR interacting HSP90 co-chaperone [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/aip

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