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Gene

MADD

MAP kinase activating death domain

Summary

Cytogenetic location
11p11.2
Coordinates
Chromosome 11: 47,270,133–47,330,031 (GRCh38)
Exons
37 exons across 59.9 kb
Protein
1,650 amino acids
Also known as
DENN, KIAA0358, RAB3GEP, IG20
MANE Select transcript
ENST00000706887.1NM_001376571.1
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads MADD yet. The test sequences your whole genome, so your data includes it all the same.

How MADD is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 11, with a bracket where MADD sits. MADD and 23 genes near it on chromosome 11, from 46,800,082 to 47,800,081.Chromosome 1111p11.2p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q2547 Mb47.2 Mb47.4 Mb47.6 Mb47.8 MbCKAP5: 46,742,768–46,846,308, reverse strandCKAP5LRP4: 46,856,717–46,918,642, reverse strandLRP4CSTPP1: 46,936,689–47,165,535, forward strandCSTPP1ARFGAP2: 47,135,667–47,177,474, reverse strandARFGAP2PACSIN3: 47,177,511–47,187,487, reverse strandPACSIN3DDB2: 47,214,435–47,240,555, forward strandDDB2ACP2: 47,237,598–47,249,288, reverse strandACP2NR1H3: 47,248,300–47,269,131, forward strandNR1H3MADD: 47,270,133–47,330,031, forward strandMADDMYBPC3: 47,331,406–47,352,702, reverse strandMYBPC3SPI1: 47,354,860–47,409,369, reverse strandSPI1SLC39A13: 47,407,132–47,416,587, forward strandSLC39A13PSMC3: 47,418,765–47,426,488, reverse strandPSMC3RAPSN: 47,436,816–47,449,192, reverse strandRAPSNCELF1: 47,465,933–47,565,569, reverse strandCELF1NDUFS3: 47,565,336–47,584,565, forward strandNDUFS3PTPMT1: 47,565,430–47,573,461, forward strandPTPMT1KBTBD4: 47,572,196–47,578,982, reverse strandKBTBD4FAM180B: 47,586,207–47,589,195, forward strandC1QTNF4: 47,589,666–47,595,642, reverse strandMTCH2: 47,604,339–47,642,698, reverse strandAGBL2: 47,659,591–47,715,389, reverse strandAGBL2FNBP4: 47,716,494–47,767,460, reverse strandFNBP4NUP160: 47,777,872–47,848,561, reverse strandNUP160Diagram of MADD: 37 exons on the forward strand of chromosome 11Exon 2: 1 known disease-causing siteExon 3: 2 known disease-causing sitesExon 5: 3 known disease-causing sitesExon 12: 1 known disease-causing siteExon 13: 3 known disease-causing sitesExon 15: 1 known disease-causing siteExon 19: 1 known disease-causing siteExon 22: 1 known disease-causing siteExon 23: 1 known disease-causing siteExon 32: 1 known disease-causing siteExon 36: 1 known disease-causing siteExon 1: 47,270,133–47,270,246, 114 basesExon 2: 47,273,827–47,273,976, 150 basesExon 3: 47,274,563–47,275,159, 597 basesExon 4: 47,275,899–47,276,202, 304 basesExon 5: 47,276,732–47,276,863, 132 basesExon 6: 47,278,165–47,278,278, 114 basesExon 7: 47,278,999–47,279,079, 81 basesExon 8: 47,281,575–47,281,753, 179 basesExon 9: 47,282,381–47,282,616, 236 basesExon 10: 47,282,813–47,282,969, 157 basesExon 11: 47,284,178–47,284,281, 104 basesExon 12: 47,284,375–47,284,565, 191 basesExon 13: 47,284,941–47,285,194, 254 basesExon 14: 47,285,451–47,285,590, 140 basesExon 15: 47,286,433–47,286,534, 102 basesExon 16: 47,288,968–47,289,027, 60 basesExon 17: 47,289,391–47,289,493, 103 basesExon 18: 47,289,867–47,290,053, 187 basesExon 19: 47,290,149–47,290,299, 151 basesExon 20: 47,290,610–47,290,816, 207 basesExon 21: 47,292,543–47,292,596, 54 basesExon 22: 47,293,883–47,293,983, 101 basesExon 23: 47,295,496–47,295,579, 84 basesExon 24: 47,295,897–47,296,055, 159 basesExon 25: 47,308,591–47,308,699, 109 basesExon 26: 47,308,980–47,309,042, 63 basesExon 27: 47,309,281–47,309,401, 121 basesExon 28: 47,309,507–47,309,612, 106 basesExon 29: 47,311,732–47,311,842, 111 basesExon 30: 47,315,220–47,315,327, 108 basesExon 31: 47,323,671–47,323,835, 165 basesExon 32: 47,324,265–47,324,337, 73 basesExon 33: 47,324,471–47,324,577, 107 basesExon 34: 47,326,544–47,326,552, 9 basesExon 35: 47,326,738–47,326,807, 70 basesExon 36: 47,328,658–47,328,704, 47 basesExon 37: 47,329,046–47,330,031, 986 bases15101520253035375′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6 kb of the gene's 59.9 kb; 4,953 of those bases code for the protein.

How a genome test reads MADD

19

positions in MADD where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 59.9 kb of MADD, introns included, not only the 6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). MADD gene: MAP kinase activating death domain. Retrieved 16 October 2026, from https://dantelabs.com/genes/madd

Vancouver

Dante Labs. MADD gene: MAP kinase activating death domain [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/madd

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