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Gene

GPR101

G protein-coupled receptor 101

Summary

Cytogenetic location
Xq26.3
Coordinates
Chromosome X: 137,023,929–137,033,995 (GRCh38)
Exons
2 exons across 10.1 kb
Protein
508 amino acids
MANE Select transcript
ENST00000651716.2NM_054021.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Familial Isolated Pituitary Adenoma (FIPA / X-LAG)

    • Familial isolated pituitary adenoma

      Pituitary adenomas occurring in two or more relatives without other endocrine tumour syndromes, including AIP-related disease and X-linked acrogigantism (GPR101).

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Carriers and relatives can be offered IGF-1 testing and pituitary imaging so tumours are found early.

How GPR101 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome X, with a bracket where GPR101 sits. GPR101 and 4 genes near it on chromosome X, from 136,528,962 to 137,528,961.Chromosome XXq26.3p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q28136.6 Mb136.8 Mb137 Mb137.2 Mb137.4 MbVGLL1: 136,532,135–136,556,807, forward strandVGLL1CD40LG: 136,648,139–136,660,390, forward strandCD40LGARHGEF6: 136,665,547–136,781,688, reverse strandARHGEF6RBMX: 136,847,801–136,880,784, reverse strandRBMXGPR101: 137,023,929–137,033,995, reverse strandGPR101Diagram of GPR101: 2 exons on the reverse strand of chromosome XExon 2: 137,023,929–137,031,766, 7,838 basesExon 1: 137,033,802–137,033,995, 194 bases215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 8 kb of the gene's 10.1 kb; 1,527 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). GPR101 gene: G protein-coupled receptor 101. Retrieved 17 October 2026, from https://dantelabs.com/genes/gpr101

Vancouver

Dante Labs. GPR101 gene: G protein-coupled receptor 101 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/gpr101

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