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Gene

WBP11

WW domain binding protein 11

Summary

Cytogenetic location
12p12.3
Coordinates
Chromosome 12: 14,784,582–14,803,478 (GRCh38)
Exons
12 exons across 18.9 kb
Protein
641 amino acids
Also known as
NPWBP, SIPP1, PPP1R165, BUG13
MANE Select transcript
ENST00000261167.7NM_016312.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads WBP11 yet. The test sequences your whole genome, so your data includes it all the same.

How WBP11 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where WBP11 sits. WBP11 and 13 genes near it on chromosome 12, from 14,294,030 to 15,294,029.Chromosome 1212p12.3p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3314.4 Mb14.6 Mb14.8 Mb15 Mb15.2 MbATF7IP: 14,365,439–14,502,931, forward strandATF7IPPLBD1: 14,503,660–14,567,928, reverse strandPLBD1GUCY2C: 14,612,632–14,696,652, reverse strandGUCY2CH4C16: 14,767,999–14,771,131, reverse strandH4C16H2AJ: 14,774,405–14,778,002, forward strandH2AJWBP11: 14,784,582–14,803,478, reverse strandWBP11C12orf60: 14,802,864–14,906,586, forward strandC12orf60SMCO3: 14,804,065–14,814,189, reverse strandSMCO3ART4: 14,822,378–14,843,630, reverse strandART4MGP: 14,879,368–14,905,245, reverse strandMGPERP27: 14,912,600–14,938,557, reverse strandERP27ARHGDIB: 14,942,009–14,961,985, reverse strandARHGDIBPDE6H: 14,949,827–14,982,699, forward strandPDE6HRERG: 15,107,783–15,390,485, reverse strandRERGDiagram of WBP11: 12 exons on the reverse strand of chromosome 12Exon 12: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 7: 2 known disease-causing sitesExon 6: 1 known disease-causing siteExon 5: 4 known disease-causing sitesExon 4: 1 known disease-causing siteExon 12: 14,784,582–14,787,498, 2,917 basesExon 11: 14,788,951–14,789,133, 183 basesExon 10: 14,790,456–14,790,749, 294 basesExon 9: 14,791,169–14,791,270, 102 basesExon 8: 14,793,731–14,793,922, 192 basesExon 7: 14,794,537–14,794,736, 200 basesExon 6: 14,794,971–14,795,104, 134 basesExon 5: 14,796,807–14,797,003, 197 basesExon 4: 14,799,635–14,799,728, 94 basesExon 3: 14,800,752–14,800,783, 32 basesExon 2: 14,801,320–14,801,428, 109 basesExon 1: 14,803,352–14,803,478, 127 bases1211109876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.6 kb of the gene's 18.9 kb; 1,926 of those bases code for the protein.

How a genome test reads WBP11

11

positions in WBP11 where ClinVar classes a change as pathogenic or likely pathogenic

1 of them (9.1%) falls in a region short reads find hard.

  • Segmental duplications (1 site)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 18.9 kb of WBP11, introns included, not only the 4.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). WBP11 gene: WW domain binding protein 11. Retrieved 16 October 2026, from https://dantelabs.com/genes/wbp11

Vancouver

Dante Labs. WBP11 gene: WW domain binding protein 11 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/wbp11

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