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Gene

AMOTL1

angiomotin like 1

Summary

Cytogenetic location
11q21
Coordinates
Chromosome 11: 94,768,356–94,876,748 (GRCh38)
Exons
13 exons across 108.4 kb
Protein
956 amino acids
Also known as
JEAP
MANE Select transcript
ENST00000433060.3NM_130847.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads AMOTL1 yet. The test sequences your whole genome, so your data includes it all the same.

How AMOTL1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 11, with a bracket where AMOTL1 sits. AMOTL1 and 13 genes near it on chromosome 11, from 94,322,552 to 95,322,551.Chromosome 1111q21p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q2594.4 Mb94.6 Mb94.8 Mb95 Mb95.2 MbGPR83: 94,377,316–94,401,428, reverse strandGPR83MRE11: 94,415,570–94,512,676, reverse strandMRE11ANKRD49: 94,493,979–94,501,935, forward strandANKRD49C11orf97: 94,512,431–94,532,200, forward strandC11orf97PIWIL4: 94,543,840–94,621,421, forward strandPIWIL4FUT4: 94,543,921–94,549,895, forward strandFUT4AMOTL1: 94,768,356–94,876,748, forward strandAMOTL1CWC15: 94,962,620–94,975,715, reverse strandCWC15KDM4D: 94,973,709–94,999,788, forward strandKDM4DKDM4E: 95,025,258–95,027,596, forward strandKDM4EKDM4F: 95,048,142–95,051,338, forward strandKDM4FSRSF8: 95,066,919–95,071,225, forward strandSRSF8ENDOD1: 95,089,566–95,134,193, forward strandENDOD1SESN3: 95,165,513–95,232,541, reverse strandSESN3Diagram of AMOTL1: 13 exons on the forward strand of chromosome 11Exon 3: 2 known disease-causing sitesExon 1: 94,768,356–94,768,560, 205 basesExon 2: 94,795,011–94,795,160, 150 basesExon 3: 94,799,390–94,800,311, 922 basesExon 4: 94,821,530–94,821,821, 292 basesExon 5: 94,830,050–94,830,194, 145 basesExon 6: 94,831,452–94,831,541, 90 basesExon 7: 94,850,114–94,850,259, 146 basesExon 8: 94,853,933–94,854,082, 150 basesExon 9: 94,859,525–94,859,715, 191 basesExon 10: 94,864,735–94,864,860, 126 basesExon 11: 94,865,942–94,866,168, 227 basesExon 12: 94,869,198–94,869,473, 276 basesExon 13: 94,870,689–94,876,748, 6,060 bases124681012135′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 9 kb of the gene's 108.4 kb; 2,871 of those bases code for the protein.

How a genome test reads AMOTL1

2

positions in AMOTL1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 108.4 kb of AMOTL1, introns included, not only the 9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). AMOTL1 gene: angiomotin like 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/amotl1

Vancouver

Dante Labs. AMOTL1 gene: angiomotin like 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/amotl1

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