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Gene

ZBTB20

zinc finger and BTB domain containing 20

Summary

Cytogenetic location
3q13.31
Coordinates
Chromosome 3: 114,314,500–115,147,288 (GRCh38)
Exons
12 exons across 832.8 kb
Protein
741 amino acids
Also known as
ODA-8S, DKFZp566F123, DPZF
Previous symbols
ZNF288
MANE Select transcript
ENST00000675478.1NM_001348800.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Diabetes Mellitus

    • A metabolic disorder characterized by abnormally high blood sugar levels due to diminished production of insulin or insulin resistance/desensitization.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Teplizumab (Tzield) for stage 2 presymptomatic T1D (FDA approved 2022); insulin replacement at clinical T1D onset; TrialNet autoantibody screening for high-risk relatives; closed-loop insulin delivery systems

How ZBTB20 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 3, with a bracket where ZBTB20 sits. ZBTB20 and 15 genes near it on chromosome 3, from 113,481,711 to 115,980,077.Chromosome 33q13.31p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q29113.5 Mb114 Mb114.5 Mb115 Mb115.5 MbSPICE1-CFAP44: 113,361,901–113,515,151, reverse strandSPICE1-CFAP44SPICE1: 113,442,718–113,515,606, reverse strandSPICE1SIDT1: 113,532,400–113,629,714, forward strandSIDT1USF3: 113,632,051–113,696,667, reverse strandUSF3NAA50: 113,716,458–113,746,786, reverse strandNAA50ATP6V1A: 113,746,296–113,812,251, forward strandATP6V1AGRAMD1C: 113,828,182–113,947,179, forward strandGRAMD1CZDHHC23: 113,947,706–113,965,401, forward strandZDHHC23CCDC191: 113,964,137–114,056,594, reverse strandCCDC191QTRT2: 114,005,833–114,088,542, forward strandQTRT2DRD3: 114,127,580–114,199,407, reverse strandDRD3ZNF80: 114,234,631–114,237,578, reverse strandZNF80TIGIT: 114,276,913–114,310,288, forward strandTIGITZBTB20: 114,314,500–115,147,288, reverse strandZBTB20GAP43: 115,623,292–115,721,490, forward strandGAP43LSAMP: 115,802,374–117,997,592, reverse strandLSAMPDiagram of ZBTB20: 12 exons on the reverse strand of chromosome 3Exon 12: 19 known disease-causing sitesExon 11: 14 known disease-causing sitesExon 10: 1 known disease-causing siteExon 12: 114,314,500–114,339,426, 24,927 basesExon 11: 114,350,274–114,351,878, 1,605 basesExon 10: 114,380,217–114,380,404, 188 basesExon 9: 114,380,777–114,380,940, 164 basesExon 8: 114,389,005–114,389,105, 101 basesExon 7: 114,500,352–114,500,391, 40 basesExon 6: 114,693,528–114,693,575, 48 basesExon 5: 114,801,101–114,801,174, 74 basesExon 4: 114,900,304–114,900,342, 39 basesExon 3: 114,974,366–114,974,416, 51 basesExon 2: 115,071,219–115,071,414, 196 basesExon 1: 115,147,219–115,147,288, 70 bases1210515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 27.5 kb of the gene's 832.8 kb; 2,226 of those bases code for the protein.

How a genome test reads ZBTB20

36

positions in ZBTB20 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 832.8 kb of ZBTB20, introns included, not only the 27.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ZBTB20 gene: zinc finger and BTB domain containing 20. Retrieved 17 October 2026, from https://dantelabs.com/genes/zbtb20

Vancouver

Dante Labs. ZBTB20 gene: zinc finger and BTB domain containing 20 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/zbtb20

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