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Gene

FLT4

fms related receptor tyrosine kinase 4

Summary

Cytogenetic location
5q35.3
Coordinates
Chromosome 5: 180,601,506–180,649,600 (GRCh38)
Exons
30 exons across 48.1 kb
Protein
1,363 amino acids
Inheritance
Autosomal dominant
Also known as
VEGFR3, PCL, VEGFR-3
MANE Select transcript
ENST00000261937.11NM_182925.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Primary Lymphoedema & Lymphatic Malformations

    • Milroy Disease (Lymphatic Malformation 1)Autosomal dominant

      Swelling of the lower legs and feet from birth or early childhood, caused by changes in FLT4.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing about it supports early compression therapy, skin care and prompt treatment of infections.

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How FLT4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 5, with a bracket where FLT4 sits. FLT4 and 12 genes near it on chromosome 5, from 180,125,553 to 181,125,552.Chromosome 55q35.3p15.33p15.32p15.31p15.2p15.1p14.3p14.2p14.1p13.3p13.2p13.1p12p11q11.1q11.2q12.1q12.2q12.3q13.1q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q31.1q31.2q31.3q32q33.1q33.2q33.3q34q35.1q35.2q35.3180.2 Mb180.4 Mb180.6 Mb180.8 Mb181 MbRASGEF1C: 180,100,795–180,209,225, reverse strandRASGEF1CMAPK9: 180,233,143–180,292,107, reverse strandMAPK9GFPT2: 180,300,668–180,353,359, reverse strandGFPT2CNOT6: 180,494,334–180,578,404, forward strandCNOT6SCGB3A1: 180,590,105–180,591,706, reverse strandSCGB3A1FLT4: 180,601,506–180,649,600, reverse strandFLT4OR2Y1: 180,739,123–180,740,058, reverse strandOR2Y1MGAT1: 180,784,780–180,815,652, reverse strandMGAT1ZFP62: 180,843,577–180,861,285, reverse strandZFP62BTNL8: 180,899,077–180,952,175, forward strandBTNL8BTNL3: 180,988,846–181,006,727, forward strandBTNL3BTNL9: 181,040,224–181,061,916, forward strandBTNL9OR2V1: 181,123,122–181,131,169, reverse strandOR2V1Diagram of FLT4: 30 exons on the reverse strand of chromosome 5Exon 29: 1 known disease-causing siteExon 25: 2 known disease-causing sitesExon 24: 1 known disease-causing siteExon 23: 2 known disease-causing sitesExon 22: 1 known disease-causing siteExon 21: 1 known disease-causing siteExon 19: 1 known disease-causing siteExon 18: 1 known disease-causing siteExon 17: 1 known disease-causing siteExon 13: 3 known disease-causing sitesExon 7: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 30: 180,601,506–180,603,390, 1,885 basesExon 29: 180,608,968–180,609,053, 86 basesExon 28: 180,609,905–180,610,025, 121 basesExon 27: 180,611,331–180,611,479, 149 basesExon 26: 180,612,506–180,612,611, 106 basesExon 25: 180,613,011–180,613,110, 100 basesExon 24: 180,614,068–180,614,179, 112 basesExon 23: 180,616,367–180,616,489, 123 basesExon 22: 180,616,900–180,616,994, 95 basesExon 21: 180,618,770–180,618,920, 151 basesExon 20: 180,619,021–180,619,109, 89 basesExon 19: 180,619,253–180,619,366, 114 basesExon 18: 180,619,665–180,619,769, 105 basesExon 17: 180,620,173–180,620,308, 136 basesExon 16: 180,620,609–180,620,715, 107 basesExon 15: 180,620,876–180,621,007, 132 basesExon 14: 180,621,106–180,621,252, 147 basesExon 13: 180,621,542–180,621,904, 363 basesExon 12: 180,622,731–180,622,839, 109 basesExon 11: 180,623,935–180,624,061, 127 basesExon 10: 180,625,869–180,626,031, 163 basesExon 9: 180,626,111–180,626,265, 155 basesExon 8: 180,628,882–180,628,999, 118 basesExon 7: 180,629,259–180,629,427, 169 basesExon 6: 180,629,696–180,629,835, 140 basesExon 5: 180,629,943–180,630,105, 163 basesExon 4: 180,630,225–180,630,337, 113 basesExon 3: 180,630,555–180,630,799, 245 basesExon 2: 180,631,682–180,631,778, 97 basesExon 1: 180,649,488–180,649,600, 113 bases3025201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.8 kb of the gene's 48.1 kb; 4,092 of those bases code for the protein.

How a genome test reads FLT4

21

positions in FLT4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 48.1 kb of FLT4, introns included, not only the 5.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). FLT4 gene: fms related receptor tyrosine kinase 4. Retrieved 16 October 2026, from https://dantelabs.com/genes/flt4

Vancouver

Dante Labs. FLT4 gene: fms related receptor tyrosine kinase 4 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/flt4

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