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Gene

IDH1

isocitrate dehydrogenase (NADP(+)) 1

Summary

Cytogenetic location
2q34
Coordinates
Chromosome 2: 208,236,229–208,255,071 (GRCh38)
Exons
10 exons across 18.8 kb
Protein
414 amino acids
MANE Select transcript
ENST00000345146.7NM_005896.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads IDH1 yet. The test sequences your whole genome, so your data includes it all the same.

How IDH1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 2, with a bracket where IDH1 sits. IDH1 and 10 genes near it on chromosome 2, from 207,745,650 to 208,745,649.Chromosome 22q34p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.3207.8 Mb208 Mb208.2 Mb208.4 Mb208.6 MbCCNYL1: 207,711,515–207,761,839, forward strandCCNYL1FZD5: 207,762,598–207,769,914, reverse strandFZD5PLEKHM3: 207,821,288–208,025,846, reverse strandPLEKHM3CRYGD: 208,121,607–208,124,595, reverse strandCRYGC: 208,128,137–208,129,828, reverse strandCRYGCCRYGB: 208,142,573–208,146,163, reverse strandCRYGBCRYGA: 208,160,740–208,163,589, reverse strandCRYGAC2orf80: 208,165,343–208,190,245, reverse strandC2orf80IDH1: 208,236,229–208,255,071, reverse strandIDH1PIKFYVE: 208,266,229–208,358,755, forward strandPIKFYVEPTH2R: 208,359,714–208,854,503, forward strandPTH2RDiagram of IDH1: 10 exons on the reverse strand of chromosome 2Exon 6: 1 known disease-causing siteExon 4: 2 known disease-causing sitesExon 10: 208,236,229–208,237,169, 941 basesExon 9: 208,239,071–208,239,233, 163 basesExon 8: 208,239,863–208,240,003, 141 basesExon 7: 208,241,994–208,242,145, 152 basesExon 6: 208,243,427–208,243,604, 178 basesExon 5: 208,245,319–208,245,424, 106 basesExon 4: 208,248,369–208,248,660, 292 basesExon 3: 208,251,430–208,251,567, 138 basesExon 2: 208,253,886–208,253,959, 74 basesExon 1: 208,254,939–208,255,071, 133 bases109876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.3 kb of the gene's 18.8 kb; 1,245 of those bases code for the protein.

How a genome test reads IDH1

3

positions in IDH1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 18.8 kb of IDH1, introns included, not only the 2.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). IDH1 gene: isocitrate dehydrogenase (NADP(+)) 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/idh1

Vancouver

Dante Labs. IDH1 gene: isocitrate dehydrogenase (NADP(+)) 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/idh1

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