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Gene

PRKACB

protein kinase cAMP-activated catalytic subunit beta

Summary

Cytogenetic location
1p31.1
Coordinates
Chromosome 1: 84,144,271–84,238,498 (GRCh38)
Exons
10 exons across 94.2 kb
Protein
398 amino acids
Also known as
PKACb
MANE Select transcript
ENST00000370685.7NM_182948.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads PRKACB yet. The test sequences your whole genome, so your data includes it all the same.

How PRKACB is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where PRKACB sits. PRKACB and 8 genes near it on chromosome 1, from 83,691,385 to 84,691,384.Chromosome 11p31.1p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q4483.8 Mb84 Mb84.2 Mb84.4 Mb84.6 MbTTLL7: 83,865,024–83,999,413, reverse strandTTLL7PRKACB: 84,144,271–84,238,498, forward strandPRKACBSAMD13: 84,298,366–84,389,957, forward strandSAMD13DNASE2B: 84,398,484–84,415,644, forward strandDNASE2BRPF1: 84,479,245–84,499,677, forward strandRPF1GNG5: 84,489,407–84,507,237, reverse strandGNG5SPATA1: 84,505,491–84,567,379, forward strandSPATA1CTBS: 84,541,988–84,574,484, reverse strandCTBSSSX2IP: 84,643,121–84,690,955, reverse strandSSX2IPDiagram of PRKACB: 10 exons on the forward strand of chromosome 1Exon 4: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 1: 84,144,271–84,144,548, 278 basesExon 2: 84,179,177–84,179,238, 62 basesExon 3: 84,182,200–84,182,328, 129 basesExon 4: 84,184,037–84,184,135, 99 basesExon 5: 84,185,100–84,185,182, 83 basesExon 6: 84,196,616–84,196,742, 127 basesExon 7: 84,197,729–84,197,824, 96 basesExon 8: 84,202,683–84,202,805, 123 basesExon 9: 84,214,153–84,214,317, 165 basesExon 10: 84,235,180–84,238,498, 3,319 bases12468105′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.5 kb of the gene's 94.2 kb; 1,197 of those bases code for the protein.

How a genome test reads PRKACB

2

positions in PRKACB where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 94.2 kb of PRKACB, introns included, not only the 4.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PRKACB gene: protein kinase cAMP-activated catalytic subunit beta. Retrieved 16 October 2026, from https://dantelabs.com/genes/prkacb

Vancouver

Dante Labs. PRKACB gene: protein kinase cAMP-activated catalytic subunit beta [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/prkacb

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