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Gene

ZFX

zinc finger protein X-linked

Summary

Cytogenetic location
Xp22.11
Coordinates
Chromosome X: 24,149,729–24,216,255 (GRCh38)
Exons
10 exons across 66.5 kb
Protein
805 amino acids
Also known as
ZNF926
MANE Select transcript
ENST00000304543.10NM_003410.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    How ZFX is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome X, with a bracket where ZFX sits. ZFX and 12 genes near it on chromosome X, from 23,682,992 to 24,682,991.Chromosome XXp22.11p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q2823.8 Mb24 Mb24.2 Mb24.4 Mb24.6 MbPRDX4: 23,664,262–23,700,980, forward strandPRDX4ACOT9: 23,699,396–23,766,475, reverse strandACOT9SAT1: 23,783,171–23,786,210, forward strandSAT1: 23,783,278–23,783,367, forward strandAPOO: 23,833,348–23,908,070, reverse strandAPOOCXorf58: 23,907,807–23,939,509, forward strandCXorf58KLHL15: 23,983,716–24,027,186, reverse strandKLHL15EIF2S3: 24,054,628–24,078,810, forward strandEIF2S3ZFX: 24,149,729–24,216,255, forward strandZFXSUPT20HL2: 24,308,210–24,314,069, reverse strandSUPT20HL2SUPT20HL1: 24,360,639–24,367,839, forward strandSUPT20HL1PDK3: 24,465,244–24,550,466, forward strandPDK3PCYT1B: 24,558,087–24,672,904, reverse strandPCYT1BDiagram of ZFX: 10 exons on the forward strand of chromosome XExon 5: 1 known disease-causing siteExon 10: 4 known disease-causing sitesExon 1: 24,149,729–24,149,794, 66 basesExon 2: 24,151,691–24,151,800, 110 basesExon 3: 24,152,720–24,152,830, 111 basesExon 4: 24,172,715–24,172,800, 86 basesExon 5: 24,179,183–24,179,770, 588 basesExon 6: 24,207,326–24,207,475, 150 basesExon 7: 24,207,712–24,207,855, 144 basesExon 8: 24,208,218–24,208,370, 153 basesExon 9: 24,208,900–24,209,040, 141 basesExon 10: 24,210,193–24,216,255, 6,063 bases15105′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 7.6 kb of the gene's 66.5 kb; 2,418 of those bases code for the protein.

    How a genome test reads ZFX

    5

    positions in ZFX where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 66.5 kb of ZFX, introns included, not only the 7.6 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). ZFX gene: zinc finger protein X-linked. Retrieved 16 October 2026, from https://dantelabs.com/genes/zfx

    Vancouver

    Dante Labs. ZFX gene: zinc finger protein X-linked [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/zfx

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