Skip to content
Use your HSA or FSA funds
Sequence your genome (opens in a new tab)

Gene

THOC2

THO complex subunit 2

Summary

Cytogenetic location
Xq25
Coordinates
Chromosome X: 123,600,569–123,733,052 (GRCh38)
Exons
39 exons across 132.5 kb
Protein
1,593 amino acids
Also known as
THO2, dJ506G2.1
Previous symbols
CXorf3, MRX12, MRX35
MANE Select transcript
ENST00000245838.13NM_001081550.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

  • Epilepsy (Full Panel)

    • X-Linked Complex Neurodevelopmental Disorder

      A complex neurodevelopmental disorder that is transmitted via X-linked inheritance, and is characterized by intellectual disability, autism and epilepsy.

      • ClinGen rates the link definitive
      • 1 GenCC submitter rates it definitive or strong

Broader groupings

How THOC2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome X, with a bracket where THOC2 sits. THOC2 and 3 genes near it on chromosome X, from 123,166,811 to 124,166,810.Chromosome XXq25p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q28123.2 Mb123.4 Mb123.6 Mb123.8 Mb124 MbGRIA3: 123,184,023–123,490,915, forward strandGRIA3THOC2: 123,600,569–123,733,052, reverse strandTHOC2XIAP: 123,859,693–123,913,972, forward strandXIAPSTAG2: 123,960,212–124,422,664, forward strandSTAG2Diagram of THOC2: 39 exons on the reverse strand of chromosome XExon 23: 2 known disease-causing sitesExon 20: 1 known disease-causing siteExon 19: 1 known disease-causing siteExon 18: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 1: 1 known disease-causing siteExon 39: 123,600,569–123,601,338, 770 basesExon 38: 123,610,918–123,610,963, 46 basesExon 37: 123,611,440–123,611,516, 77 basesExon 36: 123,613,399–123,613,556, 158 basesExon 35: 123,613,639–123,613,708, 70 basesExon 34: 123,614,052–123,614,189, 138 basesExon 33: 123,619,401–123,619,436, 36 basesExon 32: 123,620,907–123,620,965, 59 basesExon 31: 123,621,157–123,621,587, 431 basesExon 30: 123,622,758–123,622,860, 103 basesExon 29: 123,623,105–123,623,283, 179 basesExon 28: 123,623,787–123,623,971, 185 basesExon 27: 123,624,060–123,624,191, 132 basesExon 26: 123,624,541–123,624,669, 129 basesExon 25: 123,625,912–123,626,069, 158 basesExon 24: 123,626,521–123,626,662, 142 basesExon 23: 123,627,693–123,627,968, 276 basesExon 22: 123,631,688–123,631,852, 165 basesExon 21: 123,632,861–123,633,040, 180 basesExon 20: 123,633,953–123,634,070, 118 basesExon 19: 123,636,079–123,636,175, 97 basesExon 18: 123,638,043–123,638,123, 81 basesExon 17: 123,638,934–123,639,027, 94 basesExon 16: 123,640,538–123,640,622, 85 basesExon 15: 123,644,575–123,644,676, 102 basesExon 14: 123,644,779–123,644,909, 131 basesExon 13: 123,645,334–123,645,375, 42 basesExon 12: 123,665,642–123,665,837, 196 basesExon 11: 123,667,106–123,667,278, 173 basesExon 10: 123,668,159–123,668,314, 156 basesExon 9: 123,671,669–123,671,761, 93 basesExon 8: 123,686,548–123,686,714, 167 basesExon 7: 123,696,021–123,696,154, 134 basesExon 6: 123,696,721–123,696,842, 122 basesExon 5: 123,697,681–123,697,751, 71 basesExon 4: 123,703,454–123,703,505, 52 basesExon 3: 123,706,858–123,706,949, 92 basesExon 2: 123,712,850–123,712,908, 59 basesExon 1: 123,732,952–123,733,052, 101 bases39353025201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.6 kb of the gene's 132.5 kb; 4,782 of those bases code for the protein.

How a genome test reads THOC2

7

positions in THOC2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 132.5 kb of THOC2, introns included, not only the 5.6 kb of exons.

Genes linked to the same conditions

Traits linked to THOC2

The Human Phenotype Ontology lists these as features of the rare conditions THOC2 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). THOC2 gene: THO complex subunit 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/thoc2

Vancouver

Dante Labs. THOC2 gene: THO complex subunit 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/thoc2

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test