Gene
LRP2
LDL receptor related protein 2
- HGNC 6694(opens in a new tab)
- Ensembl gene ENSG00000081479(opens in a new tab)
- NCBI Gene 4036(opens in a new tab)
Summary
- Cytogenetic location
- 2q31.1
- Coordinates
- Chromosome 2: 169,127,109–169,362,534 (GRCh38)
- Exons
- 79 exons across 235.4 kb
- Protein
- 4,655 amino acids
- Also known as
- gp330, DBS
- MANE Select transcript
- ENST00000649046.1NM_004525.3
- Locus type
- gene with protein product
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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No Genome Test report reads LRP2 yet. The test sequences your whole genome, so your data includes it all the same.
How LRP2 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 15.7 kb of the gene's 235.4 kb; 13,968 of those bases code for the protein.
How a genome test reads LRP2
144
positions in LRP2 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 235.4 kb of LRP2, introns included, not only the 15.7 kb of exons.
Traits linked to LRP2
The Human Phenotype Ontology lists these as features of the rare conditions LRP2 can cause. Each trait's page lists the other genes linked to it.
Abnormality of head or neck
- Broad nasal tip
- Crease in skin under the eye
- Depressed nasal bridge
- Downward slanting of the opening between the eyelids
- Short nose
- Wider-than-typical soft spot of skull
- Widow's peak
- Big calvaria
Show 3 more traits
Abnormality of the eye
- Severe near sightedness
- Close sighted
- Wide-set eyes
- Bulging eye
- Cat eye
- Progressive loss of vision
- Retinal detachment
- Breakdown of light-sensitive cells in back of eye
Show 2 more traits
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). LRP2 gene: LDL receptor related protein 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/lrp2
Dante Labs. LRP2 gene: LDL receptor related protein 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/lrp2
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