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Gene

NKX2-6

NK2 homeobox 6

Summary

Cytogenetic location
8p21.2
Coordinates
Chromosome 8: 23,701,740–23,706,756 (GRCh38)
Exons
2 exons across 5 kb
Protein
301 amino acids
Also known as
CSX2, NKX4-2
MANE Select transcript
ENST00000325017.4NM_001136271.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads NKX2-6 yet. The test sequences your whole genome, so your data includes it all the same.

How NKX2-6 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 8, with a bracket where NKX2-6 sits. NKX2-6 and 8 genes near it on chromosome 8, from 23,204,248 to 24,204,247.Chromosome 88p21.2p23.3p23.2p23.1p22p21.3p21.2p21.1p12p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.3q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.323.4 Mb23.6 Mb23.8 Mb24 Mb24.2 MbTNFRSF10A: 23,183,123–23,225,145, reverse strandTNFRSF10ACHMP7: 23,243,630–23,266,156, forward strandCHMP7R3HCC1: 23,270,120–23,296,279, forward strandR3HCC1LOXL2: 23,296,897–23,425,328, reverse strandLOXL2ENTPD4: 23,385,783–23,457,722, reverse strandENTPD4SLC25A37: 23,528,859–23,654,350, forward strandSLC25A37NKX3-1: 23,678,697–23,682,953, reverse strandNKX3-1NKX2-6: 23,701,740–23,706,756, reverse strandNKX2-6STC1: 23,841,929–23,854,815, reverse strandSTC1Diagram of NKX2-6: 2 exons on the reverse strand of chromosome 8Exon 2: 4 known disease-causing sitesExon 2: 23,701,740–23,703,082, 1,343 basesExon 1: 23,706,325–23,706,756, 432 bases215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.8 kb of the gene's 5 kb; 906 of those bases code for the protein.

How a genome test reads NKX2-6

4

positions in NKX2-6 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 5 kb of NKX2-6, introns included, not only the 1.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). NKX2-6 gene: NK2 homeobox 6. Retrieved 16 October 2026, from https://dantelabs.com/genes/nkx2-6

Vancouver

Dante Labs. NKX2-6 gene: NK2 homeobox 6 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/nkx2-6

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