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Gene

FGFR2

fibroblast growth factor receptor 2

Summary

Cytogenetic location
10q26.13
Coordinates
Chromosome 10: 121,478,332–121,598,444 (GRCh38)
Exons
18 exons across 120.1 kb
Protein
821 amino acids
Also known as
CEK3, TK14, TK25, ECT1, K-SAM, CD332
Previous symbols
KGFR, BEK, CFD1, JWS
MANE Select transcript
ENST00000358487.10NM_000141.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Syndromic Craniosynostosis

    • Conditions combining early skull suture closure with other features, including Apert, Crouzon, Pfeiffer, Muenke and Saethre-Chotzen syndromes, caused by genes such as FGFR2, FGFR3, FGFR1, TWIST1, TCF12 and ERF.

      • ClinGen rates the link definitive
      • 6 GenCC submitters rate it definitive or strong
      What knowing changes

      Early diagnosis allows timely surgery and monitoring of head growth, vision and hearing; milder forms such as Muenke syndrome can go unrecognised in adults, which is relevant to family planning.

How FGFR2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 10, with a bracket where FGFR2 sits. FGFR2 and 3 genes near it on chromosome 10, from 121,038,388 to 122,038,387.Chromosome 1010q26.13p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.3121.2 Mb121.4 Mb121.6 Mb121.8 Mb122 MbFGFR2: 121,478,332–121,598,444, reverse strandFGFR2ATE1: 121,709,393–121,928,801, reverse strandATE1NSMCE4A: 121,953,334–121,975,300, reverse strandNSMCE4ATACC2: 121,989,163–122,254,560, forward strandTACC2Diagram of FGFR2: 18 exons on the reverse strand of chromosome 10Exon 16: 1 known disease-causing siteExon 15: 2 known disease-causing sitesExon 14: 3 known disease-causing sitesExon 13: 1 known disease-causing siteExon 12: 2 known disease-causing sitesExon 11: 1 known disease-causing siteExon 9: 4 known disease-causing sitesExon 8: 23 known disease-causing sitesExon 7: 15 known disease-causing sitesExon 3: 1 known disease-causing siteExon 18: 121,478,332–121,480,021, 1,690 basesExon 17: 121,483,698–121,483,803, 106 basesExon 16: 121,485,395–121,485,532, 138 basesExon 15: 121,487,354–121,487,424, 71 basesExon 14: 121,487,991–121,488,113, 123 basesExon 13: 121,496,532–121,496,722, 191 basesExon 12: 121,498,495–121,498,605, 111 basesExon 11: 121,500,826–121,500,947, 122 basesExon 10: 121,503,790–121,503,941, 152 basesExon 9: 121,515,117–121,515,319, 203 basesExon 8: 121,517,319–121,517,463, 145 basesExon 7: 121,519,979–121,520,169, 191 basesExon 6: 121,538,592–121,538,715, 124 basesExon 5: 121,551,290–121,551,459, 170 basesExon 4: 121,564,502–121,564,579, 78 basesExon 3: 121,565,438–121,565,704, 267 basesExon 2: 121,593,709–121,593,967, 259 basesExon 1: 121,597,962–121,598,444, 483 bases181510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.6 kb of the gene's 120.1 kb; 2,466 of those bases code for the protein.

How a genome test reads FGFR2

56

positions in FGFR2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 120.1 kb of FGFR2, introns included, not only the 4.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). FGFR2 gene: fibroblast growth factor receptor 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/fgfr2

Vancouver

Dante Labs. FGFR2 gene: fibroblast growth factor receptor 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/fgfr2

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