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Gene

NFIX

nuclear factor I X

Summary

Cytogenetic location
19p13.13
Coordinates
Chromosome 19: 12,995,475–13,098,796 (GRCh38)
Exons
11 exons across 103.3 kb
Protein
502 amino acids
Inheritance
Autosomal dominant
Also known as
NF1A
MANE Select transcript
ENST00000592199.6NM_001365902.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How NFIX is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 19, with a bracket where NFIX sits. NFIX and 40 genes near it on chromosome 19, from 12,547,136 to 13,547,135.Chromosome 1919p13.13p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4312.6 Mb12.8 Mb13 Mb13.2 Mb13.4 Mb: 12,461,559–12,551,474, reverse strandZNF564: 12,524,903–12,551,542, reverse strandZNF564: 12,525,720–12,580,975, reverse strandZNF490: 12,575,832–12,640,098, reverse strandZNF490ZNF791: 12,610,916–12,633,840, forward strandZNF791MAN2B1: 12,643,831–12,666,762, reverse strand: 12,643,831–12,648,397, reverse strand: 12,664,828–12,669,397, reverse strandWDR83: 12,666,802–12,675,832, forward strandWDR83OS: 12,668,065–12,669,467, reverse strand: 12,668,071–12,681,834, reverse strandDHPS: 12,673,411–12,681,901, reverse strandDHPSFBXW9: 12,687,801–12,696,659, reverse strandFBXW9GNG14: 12,687,998–12,688,422, forward strandGNG14TNPO2: 12,699,111–12,724,011, reverse strandTNPO2TRIR: 12,730,640–12,734,747, reverse strandTRIRGET3: 12,737,139–12,748,325, forward strandGET3BEST2: 12,751,673–12,758,458, forward strandBEST2HOOK2: 12,762,640–12,872,740, reverse strandHOOK2JUNB: 12,791,486–12,793,315, forward strandPRDX2: 12,796,817–12,801,882, reverse strandTHSD8: 12,802,031–12,813,581, forward strandRNASEH2A: 12,806,505–12,813,644, forward strandRNASEH2ARTBDN: 12,825,477–12,838,362, reverse strandRTBDNMAST1: 12,833,860–12,874,952, forward strandMAST1DNASE2: 12,875,209–12,881,595, reverse strandKLF1: 12,884,405–12,887,201, reverse strandKLF1GCDH: 12,891,128–12,915,261, forward strandSYCE2: 12,898,786–12,919,306, reverse strandFARSA: 12,921,138–12,934,037, reverse strandCALR: 12,938,578–12,944,525, forward strandCALRRAD23A: 12,945,716–12,953,646, forward strandRAD23AGADD45GIP1: 12,950,701–12,957,333, reverse strandGADD45GIP1DAND5: 12,965,159–12,974,760, forward strandDAND5NFIX: 12,995,475–13,098,796, forward strandNFIXLYL1: 13,099,028–13,103,188, reverse strandLYL1TRMT1: 13,104,899–13,117,567, reverse strandTRMT1NACC1: 13,116,468–13,141,147, forward strandNACC1STX10: 13,144,058–13,150,383, reverse strandSTX10IER2: 13,150,403–13,156,981, forward strandIER2CACNA1A: 13,206,442–13,624,489, reverse strandCACNA1ADiagram of NFIX: 11 exons on the forward strand of chromosome 19Exon 2: 54 known disease-causing sitesExon 3: 2 known disease-causing sitesExon 4: 4 known disease-causing sitesExon 5: 4 known disease-causing sitesExon 6: 5 known disease-causing sitesExon 7: 3 known disease-causing sitesExon 8: 7 known disease-causing sitesExon 10: 3 known disease-causing sitesExon 1: 12,995,475–12,995,864, 390 basesExon 2: 13,025,021–13,025,552, 532 basesExon 3: 13,073,047–13,073,109, 63 basesExon 4: 13,073,422–13,073,496, 75 basesExon 5: 13,073,906–13,074,026, 121 basesExon 6: 13,075,535–13,075,671, 137 basesExon 7: 13,078,613–13,078,735, 123 basesExon 8: 13,081,680–13,081,855, 176 basesExon 9: 13,087,989–13,088,136, 148 basesExon 10: 13,090,299–13,090,390, 92 basesExon 11: 13,094,635–13,098,796, 4,162 bases1246810115′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6 kb of the gene's 103.3 kb; 1,509 of those bases code for the protein.

How a genome test reads NFIX

89

positions in NFIX where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 103.3 kb of NFIX, introns included, not only the 6 kb of exons.

Traits linked to NFIX

The Human Phenotype Ontology lists these as features of the rare conditions NFIX can cause. Each trait's page lists the other genes linked to it.

Abnormality of head or neck

Show 51 more traits

Abnormality of the nervous system

Show 23 more traits

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). NFIX gene: nuclear factor I X. Retrieved 17 October 2026, from https://dantelabs.com/genes/nfix

Vancouver

Dante Labs. NFIX gene: nuclear factor I X [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/nfix

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