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Gene

HRAS

HRas proto-oncogene, GTPase

Summary

Cytogenetic location
11p15.5
Coordinates
Chromosome 11: 532,242–535,576 (GRCh38)
Exons
6 exons across 3.3 kb
Protein
189 amino acids
Inheritance
Autosomal dominant
Previous symbols
HRAS1
MANE Select transcript
ENST00000311189.8NM_005343.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Noonan Syndrome

    • Noonan Syndrome and Noonan-Related Syndromes

      A group of RAS pathway conditions, including Noonan, Costello, cardiofaciocutaneous and Legius syndromes, with variable heart defects, short stature and distinctive facial features.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing about it supports heart, growth and developmental assessment.

Broader groupings

  • Hypertrophic Cardiomyopathy

    • Autosomal dominant

      One of 62 genes linked to it

      A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Beta-blockers, non-dihydropyridine calcium channel blockers, activity restriction, genetic counseling

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How HRAS is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Variants with a page
Chromosome 11, with a bracket where HRAS sits. HRAS and 46 genes near it on chromosome 11, from 33,909 to 1,033,908.Chromosome 1111p15.5p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q250.2 Mb0.4 Mb0.6 Mb0.8 Mb1 MbBET1L: 167,784–208,695, reverse strandBET1LSCGB1C1: 193,078–194,575, forward strandCIMAP1A: 196,761–200,261, forward strandCIMAP1ARIC8A: 207,478–215,164, forward strandRIC8ASIRT3: 215,026–236,931, reverse strandSIRT3PSMD13: 236,948–252,986, forward strandPSMD13NLRP6: 278,407–286,691, forward strandPGGHG: 289,078–297,510, forward strandIFITM5: 298,200–299,533, reverse strandIFITM2: 303,655–309,410, forward strandIFITM2: 308,408–315,272, forward strandIFITM3: 309,010–329,475, reverse strandIFITM3IFITM1: 309,997–315,275, forward strandIFITM1B4GALNT4: 369,457–382,117, forward strandB4GALNT4PKP3: 392,574–404,908, forward strandPKP3SIGIRR: 405,711–417,473, reverse strandSIGIRRANO9: 417,921–442,072, reverse strandANO9PTDSS2: 448,268–501,142, forward strandPTDSS2RNH1: 494,510–507,395, reverse strandRNH1HRAS: 532,242–535,576, reverse strandHRASLRRC56: 536,841–554,925, forward strandLRRC56LMNTD2: 554,850–560,743, reverse strandLMNTD2RASSF7: 560,207–564,067, forward strandRASSF7PHRF1: 576,170–612,263, forward strandPHRF1IRF7: 612,551–615,983, reverse strandIRF7CDHR5: 616,405–626,078, reverse strandCDHR5SCT: 626,309–627,236, reverse strandSCTDRD4: 637,269–640,706, forward strandDEAF1: 644,220–707,118, reverse strandDEAF1EPS8L2: 694,438–727,729, forward strandEPS8L2TMEM80: 695,011–705,028, forward strandTMEM80TALDO1: 747,399–765,035, forward strandTALDO1GATD1: 767,061–777,507, reverse strandGATD1CEND1: 785,900–790,113, reverse strandCEND1SLC25A22: 790,474–798,321, reverse strandSLC25A22PANO1: 797,511–799,190, forward strandPIDD1: 798,938–809,753, reverse strandRPLP2: 799,414–812,891, forward strand: 803,398–804,419, reverse strandPNPLA2: 818,907–825,573, forward strandCRACR2B: 826,137–831,993, forward strandCD151: 832,702–839,831, forward strandPOLR2L: 837,356–842,727, reverse strandTSPAN4: 840,686–867,120, forward strandTSPAN4CHID1: 866,873–915,579, reverse strandCHID1AP2A2: 924,881–1,012,245, forward strandAP2A2MUC6: 1,012,823–1,036,718, reverse strandMUC6Diagram of HRAS: 6 exons on the reverse strand of chromosome 11Exon 5: 1 known disease-causing siteExon 4: 2 known disease-causing sitesExon 3: 13 known disease-causing sitesExon 2: 7 known disease-causing sitesExon 6: 532,242–532,522, 281 basesExon 5: 532,631–532,755, 125 basesExon 4: 533,453–533,612, 160 basesExon 3: 533,766–533,944, 179 basesExon 2: 534,212–534,375, 164 bases. 2 variants with a page in exon 2. List themExon 1: 535,416–535,576, 161 bases6543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.1 kb of the gene's 3.3 kb; 570 of those bases code for the protein.

How a genome test reads HRAS

24

positions in HRAS where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 3.3 kb of HRAS, introns included, not only the 1.1 kb of exons.

Variants with a page (2)

The HRAS variants with a page here, most review stars first. Each page describes ClinVar's public record of the variant, never a result.

VariantHGVS c.Exon or intronPosition (GRCh38)ClinVar classificationReview status
G12Sc.34G>AExon 2534,289Pathogenic3 stars out of 4 reviewed by expert panel
G13Cc.37G>TExon 2534,286Pathogenic3 stars out of 4 reviewed by expert panel

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). HRAS gene: HRas proto-oncogene, GTPase. Retrieved 17 October 2026, from https://dantelabs.com/genes/hras

Vancouver

Dante Labs. HRAS gene: HRas proto-oncogene, GTPase [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/hras

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