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Gene

KANSL1

KAT8 regulatory NSL complex subunit 1

Summary

Cytogenetic location
17q21.31
Coordinates
Chromosome 17: 46,029,916–46,193,429 (GRCh38)
Exons
15 exons across 163.5 kb
Protein
1,105 amino acids
Also known as
DKFZP727C091, MSL1v1, CENP-36, NSL1
Previous symbols
KIAA1267
MANE Select transcript
ENST00000432791.7NM_015443.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Intellectual Disability

      • One of 233 genes linked to it

        • ClinGen rates the link definitive
        • 5 GenCC submitters rate it definitive or strong

    How KANSL1 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 17, with a bracket where KANSL1 sits. KANSL1 and 10 genes near it on chromosome 17, from 45,611,673 to 46,611,672.Chromosome 1717q21.31p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.345.8 Mb46 Mb46.2 Mb46.4 Mb46.6 MbLINC02210-CRHR1: 45,620,344–45,835,826, forward strandLINC02210-CRHR1CRHR1: 45,784,277–45,835,828, forward strandCRHR1SPPL2C: 45,844,881–45,847,067, forward strandSPPL2CMAPT: 45,894,278–46,028,334, forward strandMAPTSTH: 45,999,250–45,999,694, forward strandSTHKANSL1: 46,029,916–46,193,429, reverse strandKANSL1ARL17B: 46,271,629–46,361,793, reverse strandARL17BLRRC37A: 46,292,733–46,338,077, forward strandLRRC37AARL17A: 46,431,431–46,579,725, reverse strandARL17ALRRC37A2: 46,511,508–46,556,910, forward strandLRRC37A2NSF: 46,590,661–46,757,679, forward strandNSFDiagram of KANSL1: 15 exons on the reverse strand of chromosome 17Exon 15: 2 known disease-causing sitesExon 14: 4 known disease-causing sitesExon 13: 5 known disease-causing sitesExon 12: 2 known disease-causing sitesExon 11: 2 known disease-causing sitesExon 10: 2 known disease-causing sitesExon 9: 3 known disease-causing sitesExon 8: 5 known disease-causing sitesExon 7: 5 known disease-causing sitesExon 6: 6 known disease-causing sitesExon 5: 1 known disease-causing siteExon 4: 2 known disease-causing sitesExon 3: 6 known disease-causing sitesExon 2: 22 known disease-causing sitesExon 15: 46,029,916–46,031,703, 1,788 basesExon 14: 46,032,047–46,032,299, 253 basesExon 13: 46,033,080–46,033,192, 113 basesExon 12: 46,033,403–46,033,460, 58 basesExon 11: 46,034,161–46,034,285, 125 basesExon 10: 46,038,538–46,038,686, 149 basesExon 9: 46,039,027–46,039,215, 189 basesExon 8: 46,039,702–46,039,884, 183 basesExon 7: 46,050,533–46,050,704, 172 basesExon 6: 46,066,537–46,066,732, 196 basesExon 5: 46,067,549–46,067,667, 119 basesExon 4: 46,082,441–46,082,542, 102 basesExon 3: 46,094,560–46,094,701, 142 basesExon 2: 46,170,855–46,172,232, 1,378 basesExon 1: 46,192,823–46,193,429, 607 bases1510515′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 5.6 kb of the gene's 163.5 kb; 3,318 of those bases code for the protein.

    How a genome test reads KANSL1

    78

    positions in KANSL1 where ClinVar classes a change as pathogenic or likely pathogenic

    7 of them (9%) fall in regions short reads find hard.

    • Low mappability (1 site)Regions where 100 bp or 250 bp reads cannot be placed uniquely.
    • Segmental duplications (7 sites)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

    A whole genome covers all 163.5 kb of KANSL1, introns included, not only the 5.6 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). KANSL1 gene: KAT8 regulatory NSL complex subunit 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/kansl1

    Vancouver

    Dante Labs. KANSL1 gene: KAT8 regulatory NSL complex subunit 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/kansl1

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