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Gene

ROBO1

roundabout guidance receptor 1

Summary

Cytogenetic location
3p12.3
Coordinates
Chromosome 3: 78,597,239–79,767,998 (GRCh38)
Exons
31 exons across 1,170.8 kb
Protein
1,651 amino acids
Also known as
DUTT1, FLJ21882, SAX3
MANE Select transcript
ENST00000464233.6NM_002941.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Hypogonadotropic Hypogonadism

    • Abnormal ovarian or testicular function due to insufficient hormonal stimulation from the hypothalamic-pituitary axis.

      • 2 GenCC submitters rate it definitive or strong

  • Non-Acquired Combined Pituitary Hormone Deficiency

    • Combined pituitary hormone deficiency, genetic form

      Inherited deficiency of several pituitary hormones, including PROP1, POU1F1, HESX1 and related causes.

      • 2 GenCC submitters rate it definitive or strong

How ROBO1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 3, with a bracket where ROBO1 sits. ROBO1 and 1 gene near it on chromosome 3, from 77,426,479 to 80,938,758.Chromosome 33p12.3p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q2977.5 Mb78 Mb78.5 Mb79 Mb79.5 Mb80 Mb80.5 MbROBO2: 75,906,667–77,649,964, forward strandROBO2ROBO1: 78,597,239–79,767,998, reverse strandROBO1Diagram of ROBO1: 31 exons on the reverse strand of chromosome 3Exon 30: 1 known disease-causing siteExon 29: 3 known disease-causing sitesExon 18: 1 known disease-causing siteExon 11: 2 known disease-causing sitesExon 9: 1 known disease-causing siteExon 5: 2 known disease-causing sitesExon 4: 1 known disease-causing siteExon 31: 78,597,239–78,598,927, 1,689 basesExon 30: 78,600,113–78,600,309, 197 basesExon 29: 78,606,733–78,607,041, 309 basesExon 28: 78,614,648–78,614,800, 153 basesExon 27: 78,617,635–78,618,041, 407 basesExon 26: 78,627,321–78,627,569, 249 basesExon 25: 78,631,161–78,631,305, 145 basesExon 24: 78,633,935–78,634,042, 108 basesExon 23: 78,635,773–78,636,108, 336 basesExon 22: 78,639,744–78,639,898, 155 basesExon 21: 78,646,148–78,646,190, 43 basesExon 20: 78,647,629–78,647,655, 27 basesExon 19: 78,651,732–78,651,929, 198 basesExon 18: 78,657,098–78,657,269, 172 basesExon 17: 78,659,686–78,659,807, 122 basesExon 16: 78,661,030–78,661,261, 232 basesExon 15: 78,661,993–78,662,114, 122 basesExon 14: 78,667,883–78,668,049, 167 basesExon 13: 78,668,134–78,668,302, 169 basesExon 12: 78,668,484–78,668,565, 82 basesExon 11: 78,670,096–78,670,301, 206 basesExon 10: 78,685,746–78,685,917, 172 basesExon 9: 78,688,648–78,688,772, 125 basesExon 8: 78,714,397–78,714,524, 128 basesExon 7: 78,717,275–78,717,413, 139 basesExon 6: 78,717,763–78,717,883, 121 basesExon 5: 78,746,743–78,746,900, 158 basesExon 4: 78,938,601–78,938,927, 327 basesExon 3: 79,125,456–79,125,539, 84 basesExon 2: 79,589,824–79,589,961, 138 basesExon 1: 79,767,752–79,767,998, 247 bases312015′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.9 kb of the gene's 1,170.8 kb; 4,956 of those bases code for the protein.

How a genome test reads ROBO1

14

positions in ROBO1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 1,170.8 kb of ROBO1, introns included, not only the 6.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ROBO1 gene: roundabout guidance receptor 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/robo1

Vancouver

Dante Labs. ROBO1 gene: roundabout guidance receptor 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/robo1

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