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Gene

ALPK3

alpha kinase 3

Summary

Cytogenetic location
15q25.3
Coordinates
Chromosome 15: 84,817,356–84,873,479 (GRCh38)
Exons
14 exons across 56.1 kb
Protein
1,705 amino acids
Inheritance
Autosomal dominant
Also known as
MAK, KIAA1330, Midori
MANE Select transcript
ENST00000258888.6NM_020778.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Hypertrophic Cardiomyopathy

      • Autosomal dominant

        One of 62 genes linked to it

        A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.

        • ClinGen rates the link definitive
        • 4 GenCC submitters rate it definitive or strong
        What knowing changes

        Beta-blockers, non-dihydropyridine calcium channel blockers, activity restriction, genetic counseling

    Inheritance

    Autosomal dominant
    One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

    How ALPK3 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 15, with a bracket where ALPK3 sits. ALPK3 and 7 genes near it on chromosome 15, from 84,345,418 to 85,345,417.Chromosome 1515q25.3p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.384.4 Mb84.6 Mb84.8 Mb85 Mb85.2 MbZSCAN2: 84,600,986–84,627,796, forward strandZSCAN2WDR73: 84,639,283–84,654,343, reverse strandWDR73NMB: 84,655,129–84,661,271, reverse strandNMBSEC11A: 84,669,529–84,716,466, reverse strandSEC11AZNF592: 84,748,348–84,806,445, forward strandZNF592ALPK3: 84,817,356–84,873,479, forward strandALPK3SLC28A1: 84,884,569–84,975,691, forward strandSLC28A1PDE8A: 84,980,440–85,139,244, forward strandPDE8ADiagram of ALPK3: 14 exons on the forward strand of chromosome 15Exon 1: 5 known disease-causing sitesExon 3: 2 known disease-causing sitesExon 4: 2 known disease-causing sitesExon 5: 25 known disease-causing sitesExon 6: 29 known disease-causing sitesExon 7: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 10: 8 known disease-causing sitesExon 11: 1 known disease-causing siteExon 12: 2 known disease-causing sitesExon 13: 1 known disease-causing siteExon 1: 84,817,356–84,817,595, 240 basesExon 2: 84,823,330–84,823,368, 39 basesExon 3: 84,827,484–84,827,605, 122 basesExon 4: 84,838,980–84,839,097, 118 basesExon 5: 84,839,702–84,840,932, 1,231 basesExon 6: 84,856,392–84,858,555, 2,164 basesExon 7: 84,859,243–84,859,390, 148 basesExon 8: 84,859,776–84,859,903, 128 basesExon 9: 84,860,037–84,860,072, 36 basesExon 10: 84,862,635–84,862,915, 281 basesExon 11: 84,863,552–84,863,640, 89 basesExon 12: 84,864,442–84,864,665, 224 basesExon 13: 84,867,317–84,867,365, 49 basesExon 14: 84,868,111–84,873,479, 5,369 bases124681012145′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 10.2 kb of the gene's 56.1 kb; 5,118 of those bases code for the protein.

    How a genome test reads ALPK3

    83

    positions in ALPK3 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 56.1 kb of ALPK3, introns included, not only the 10.2 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). ALPK3 gene: alpha kinase 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/alpk3

    Vancouver

    Dante Labs. ALPK3 gene: alpha kinase 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/alpk3

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