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Gene

PPP2CA

protein phosphatase 2 catalytic subunit alpha

Summary

Cytogenetic location
5q31.1
Coordinates
Chromosome 5: 134,194,332–134,226,073 (GRCh38)
Exons
7 exons across 31.7 kb
Protein
309 amino acids
Also known as
PP2Calpha, PP2AC
MANE Select transcript
ENST00000481195.6NM_002715.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads PPP2CA yet. The test sequences your whole genome, so your data includes it all the same.

How PPP2CA is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 5, with a bracket where PPP2CA sits. PPP2CA and 12 genes near it on chromosome 5, from 133,710,203 to 134,710,202.Chromosome 55q31.1p15.33p15.32p15.31p15.2p15.1p14.3p14.2p14.1p13.3p13.2p13.1p12p11q11.1q11.2q12.1q12.2q12.3q13.1q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q31.1q31.2q31.3q32q33.1q33.2q33.3q34q35.1q35.2q35.3133.8 Mb134 Mb134.2 Mb134.4 Mb134.6 MbC5orf15: 133,955,498–133,968,674, reverse strandC5orf15VDAC1: 133,971,871–134,005,360, reverse strandVDAC1TCF7: 134,114,645–134,151,865, forward strandTCF7SKP1: 134,145,693–134,177,911, reverse strandSKP1: 134,157,088–134,225,861, reverse strandPPP2CA: 134,194,332–134,226,073, reverse strandPPP2CA: 134,196,905–134,371,044, reverse strandCDKL3: 134,286,350–134,371,047, reverse strandCDKL3UBE2B: 134,371,174–134,394,447, forward strandUBE2BXTBD1: 134,373,327–134,411,902, reverse strandXTBD1JADE2: 134,523,979–134,583,230, forward strandJADE2SAR1B: 134,601,149–134,649,271, reverse strandSAR1BSEC24A: 134,648,587–134,727,911, forward strandSEC24ADiagram of PPP2CA: 7 exons on the reverse strand of chromosome 5Exon 7: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 5: 6 known disease-causing sitesExon 4: 2 known disease-causing sitesExon 3: 5 known disease-causing sitesExon 2: 2 known disease-causing sitesExon 1: 1 known disease-causing siteExon 7: 134,194,332–134,197,844, 3,513 basesExon 6: 134,199,086–134,199,204, 119 basesExon 5: 134,200,335–134,200,496, 162 basesExon 4: 134,200,985–134,201,074, 90 basesExon 3: 134,201,848–134,202,021, 174 basesExon 2: 134,205,922–134,206,131, 210 basesExon 1: 134,225,760–134,226,073, 314 bases76543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.6 kb of the gene's 31.7 kb; 930 of those bases code for the protein.

How a genome test reads PPP2CA

19

positions in PPP2CA where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 31.7 kb of PPP2CA, introns included, not only the 4.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PPP2CA gene: protein phosphatase 2 catalytic subunit alpha. Retrieved 16 October 2026, from https://dantelabs.com/genes/ppp2ca

Vancouver

Dante Labs. PPP2CA gene: protein phosphatase 2 catalytic subunit alpha [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/ppp2ca

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