Traits

Traits linked to TP63

tumor protein p63

The Human Phenotype Ontology links 248 traits to TP63, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
Absent lacrimal punctum	Always
Bilateral blockage of the rear opening of the nasal cavity	Always
Both sided cleft lip	Always
Cleft palate	Always
Cleft upper lip	Always
Dental cavities	Always
Failure of development of between one and six teeth	Always
Narrow mouth	Always
Narrowing of the tear duct	Always
One sided cleft palate	Always
One sided cleft upper lip	Always
Sparse eyebrow	Always
Sparse eyelashes	Always
Taurodontia	Always
Thin dental enamel	Always
Abnormal dentition	Very often (80–99%)
Abnormal tooth enamel	Very often (80–99%)
Abnormality of tooth eruption	Very often (80–99%)
Adhesion of eyelids	Very often (80–99%)
Blocked tear duct	Very often (80–99%)
Decreased number of teeth	Very often (80–99%)
Decreased size of tooth	Very often (80–99%)
Lip pit	Very often (80–99%)
Thick eyebrow	Very often (80–99%)
Unopened tear duct	Very often (80–99%)
Abnormal of nasal shape	Often (30–79%)
Abnormality of dental shape	Often (30–79%)
Abnormality of masticatory muscle	Often (30–79%)
Abnormality of the face	Often (30–79%)
Chewing difficulties	Often (30–79%)
Cleft lip	Often (30–79%)
Cleft of the mouth	Often (30–79%)
Dacryocystitis	Often (30–79%)
Disturbance of facial expression	Often (30–79%)
Inflammation of eyelids	Often (30–79%)
Keratoconjunctivitis	Often (30–79%)
Non-midline cleft of the upper lip	Often (30–79%)
Sparse scalp hair	Often (30–79%)
Velopharyngeal incompetence	Often (30–79%)
Abnormal number of permanent teeth	Sometimes (5–29%)
Abnormality of septum of nose	Sometimes (5–29%)
Bad bite	Sometimes (5–29%)
Bifid uvula	Sometimes (5–29%)
Blockage of the rear opening of the nasal cavity	Sometimes (5–29%)
Chronic irritative conjunctivitis	Sometimes (5–29%)
Cleft hard palate	Sometimes (5–29%)
Decreased salivary flow	Sometimes (5–29%)
Extra upper front tooth	Sometimes (5–29%)
Eyelid folded in	Sometimes (5–29%)
Hole in roof of mouth	Sometimes (5–29%)
Increased size of tooth	Sometimes (5–29%)
Missing lateral incisor	Sometimes (5–29%)
Peg-shaped maxillary lateral incisors	Sometimes (5–29%)
Prominent nasal bridge	Sometimes (5–29%)
Right and left cleft palate	Sometimes (5–29%)
Submucous cleft soft palate	Sometimes (5–29%)
Wide nasal bridge	Sometimes (5–29%)
Decreased size of maxilla	Rarely (1–4%)
Zygomatic flattening	Rarely (1–4%)
Abnormal nasopharynx morphology	Not recorded
Absence of a tooth	Not recorded
Absence of scalp hair	Not recorded
Absence of Stensen duct	Not recorded
Absent eyelashes	Not recorded
Cone shaped tooth	Not recorded
Depressed nasal bridge	Not recorded
Depressed nasal tip	Not recorded
Early loss of adult teeth	Not recorded
Failure of development of more than six teeth	Not recorded
High forehead	Not recorded
Narrow nose	Not recorded
Narrow opening between the eyelids	Not recorded
Oval face	Not recorded
Pink eye	Not recorded
Small, cone shaped teeth	Not recorded
Underdeveloped tissue around nostril	Not recorded
Widely spaced teeth	Not recorded

Abnormality of the integument

Trait	How often it is seen
Dry skin	Always
Ectodermal dysplasia	Always
Flattened and twisted hair	Always
Lack of sweating	Always
Poor nail formation	Always
Slow-growing hair	Always
Sparse body hair	Always
Uncombable hair	Always
Abnormal fingernail development	Very often (80–99%)
Abnormal toenail development	Very often (80–99%)
Abnormality of the nail	Very often (80–99%)
Beauty mark	Very often (80–99%)
Coarse hair	Very often (80–99%)
Fine hair	Very often (80–99%)
Freckling	Very often (80–99%)
Hyperkeratosis	Very often (80–99%)
Nail pits	Very often (80–99%)
Open skin sore	Very often (80–99%)
Thin skin	Very often (80–99%)
Absent/small skin	Often (30–79%)
Excessive face hair	Often (30–79%)
Fair skin	Often (30–79%)
Hair loss	Often (30–79%)
Atypical nail growth	Sometimes (5–29%)
Decreased ability to sweat	Sometimes (5–29%)
Mole	Sometimes (5–29%)
Sparse hair	Sometimes (5–29%)
Multiple birthmarks	Rarely (1–4%)
Absent nails	Not recorded
Adermatoglyphia	Not recorded
Decreased sweat glands	Not recorded
Fair hair	Not recorded
Increased nail curvature	Not recorded
Limited armpit hair	Not recorded
Patchy baldness	Not recorded
Patchy darkened skin	Not recorded
Photosensitive skin	Not recorded
Pili canaliculi	Not recorded
Progressive alopecia	Not recorded
Skin degeneration	Not recorded
Small nail	Not recorded
Sparse pubic hair	Not recorded
Thick nail	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Abnormality of the clit	Very often (80–99%)
Epispadias	Very often (80–99%)
Underdeveloped penis	Very often (80–99%)
Vesicoureteral reflux	Very often (80–99%)
Abnormality of the ureter	Often (30–79%)
Absent/small kidney	Often (30–79%)
Frequent urinary tract infections	Often (30–79%)
Hydronephrosis	Often (30–79%)
Hypospadias	Often (30–79%)
Previous menstrual periods stop	Often (30–79%)
Primary amenorrhea	Often (30–79%)
Streak ovary	Often (30–79%)
Urethral atresia	Often (30–79%)
Absent ovary	Rarely (1–4%)
Absent uterus	Rarely (1–4%)
Absent kidney	Not recorded
Bladder diverticulum	Not recorded
Duplicated collecting system	Not recorded
Hydroureter	Not recorded
Megacystis	Not recorded
Narrowing of the urethra	Not recorded
Renal dysplasia	Not recorded
Short penis	Not recorded
Small labia majora	Not recorded
Transverse vaginal septum	Not recorded
Undescended testes	Not recorded
Ureterocele	Not recorded
Vaginal dryness	Not recorded

Abnormality of limbs

Trait	How often it is seen
Thickening of palms and soles	Always
Webbed skin of 2nd-3rd toes	Always
Cleft hand	Very often (80–99%)
Finger syndactyly	Very often (80–99%)
Fused toes	Very often (80–99%)
Oligodactyly	Very often (80–99%)
Split foot	Very often (80–99%)
Split hand	Very often (80–99%)
Duplication of hand bones	Often (30–79%)
Hand monodactyly	Often (30–79%)
3-4 finger cutaneous syndactyly	Sometimes (5–29%)
Absent hand	Sometimes (5–29%)
Absent/small thumb	Sometimes (5–29%)
Attachment of thumb close to wrist	Sometimes (5–29%)
Curvature of little finger	Sometimes (5–29%)
Webbed fingers or toes	Sometimes (5–29%)
Club feet	Rarely (1–4%)
Absent/small long bone of foot	Not recorded
Absent/small long bones of hand	Not recorded
Absent/small toe bones	Not recorded
Aplasia/Hypoplasia of the phalanges of the hand	Not recorded
Bunion	Not recorded
Finger-like thumb	Not recorded
Joint contracture of the hand	Not recorded
Webbed 2nd and 3rd toes	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Abnormality of the anus	Very often (80–99%)
Bladder exstrophy	Very often (80–99%)
Umbilical hernia	Very often (80–99%)
Anteriorly placed anus	Often (30–79%)
Feeding difficulties in infancy	Often (30–79%)
Inguinal hernia	Often (30–79%)
Narrowing of anal opening	Often (30–79%)
Nasogastric tube feeding in infancy	Often (30–79%)
Oral-pharyngeal dysphagia	Often (30–79%)
Poor suck	Often (30–79%)
Intestinal malrotation	Sometimes (5–29%)
Loss of bowel control	Sometimes (5–29%)
Malnutrition	Sometimes (5–29%)
Omphalocele	Sometimes (5–29%)
Poor swallowing	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Narrow ear canal	Always
Chronic infections of the middle ear	Often (30–79%)
Recurrent middle ear infection	Often (30–79%)
Abnormal Eustachian tube morphology	Sometimes (5–29%)
Abnormality of the inner ear	Sometimes (5–29%)
Abnormality of the middle ear	Sometimes (5–29%)
Abnormally shaped ears	Sometimes (5–29%)
Conductive deafness	Sometimes (5–29%)
Sensorineural hearing impairment	Sometimes (5–29%)
Prominent ear	Rarely (1–4%)
Absent ear canal	Not recorded
Hearing impairment	Not recorded
Small ears	Not recorded

Abnormality of the breast

Trait	How often it is seen
Accessory nipple	Always
Small nipples	Always
Absent breast	Often (30–79%)
Absent nipple	Often (30–79%)
Two underdeveloped breasts	Often (30–79%)
Underdeveloped breasts	Often (30–79%)
Absent/small breasts	Sometimes (5–29%)
Absent/small nipples	Sometimes (5–29%)
Wide-spaced nipples	Not recorded

Abnormality of the eye

Trait	How often it is seen
Absence of tears in the eyes	Always
Abnormality of tear production	Very often (80–99%)
Corneal inflammation	Often (30–79%)
Damage to outer layer of the cornea of the eye	Often (30–79%)
Extreme sensitivity of the eyes to light	Often (30–79%)
Inflammatory abnormality of the eye	Often (30–79%)
Absent iris	Sometimes (5–29%)
Blue eyes	Not recorded
Drooping upper eyelid	Not recorded

Abnormality of the endocrine system

Trait	How often it is seen
Decreased serum estradiol	Always
Elevated circulating follicle stimulating hormone level	Always
Anterior hypopituitarism	Sometimes (5–29%)
Decreased response to growth hormone stimulation test	Sometimes (5–29%)
Precocious puberty in females	Sometimes (5–29%)
Central diabetes insipidus	Not recorded
Hypogonadotropic hypogonadism	Not recorded

Abnormality of the nervous system

Trait	How often it is seen
Delayed speech and language development	Often (30–79%)
Speech articulation difficulties	Often (30–79%)
Behavioral abnormality	Sometimes (5–29%)
Intellectual disability	Sometimes (5–29%)
Low self-esteem	Sometimes (5–29%)
Specific learning disability	Rarely (1–4%)
Abnormality of the nervous system	Not recorded

Abnormality of the cardiovascular system

Trait	How often it is seen
Small thymus	Sometimes (5–29%)
All organs on wrong side of body	Rarely (1–4%)
Hole in heart wall separating two lower heart chambers	Not recorded
Patent ductus arteriosus	Not recorded

Abnormality of prenatal development or birth

Trait	How often it is seen
Amniotic constriction ring	Sometimes (5–29%)
High levels of amniotic fluid	Rarely (1–4%)

Abnormality of the immune system

Trait	How often it is seen
Psoriasiform dermatitis	Rarely (1–4%)
Eczema	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Small sacrum	Often (30–79%)
Permanent flexion of the finger or toe	Not recorded

Growth abnormality

Trait	How often it is seen
Short stature	Sometimes (5–29%)
Small for gestational age	Sometimes (5–29%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Cancer of lymphatic system	Sometimes (5–29%)

Abnormality of the respiratory system

Trait	How often it is seen
Abnormal pattern of respiration	Often (30–79%)

Abnormality of the voice

Trait	How often it is seen
Nasal speech	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TP63 and how often each is seen. Find out more at hpo.jax.org.

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