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Gene

DHODH

dihydroorotate dehydrogenase (quinone)

Summary

Cytogenetic location
16q22.2
Coordinates
Chromosome 16: 72,008,744–72,027,659 (GRCh38)
Exons
9 exons across 18.9 kb
Protein
395 amino acids
MANE Select transcript
ENST00000219240.9NM_001361.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads DHODH yet. The test sequences your whole genome, so your data includes it all the same.

How DHODH is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 16, with a bracket where DHODH sits. DHODH and 16 genes near it on chromosome 16, from 71,518,202 to 72,518,201.Chromosome 1616q22.2p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.371.6 Mb71.8 Mb72 Mb72.2 Mb72.4 MbZNF19: 71,464,555–71,565,502, reverse strandZNF19CHST4: 71,525,233–71,541,950, forward strandCHST4TAT: 71,565,660–71,577,096, reverse strandTATMARVELD3: 71,626,150–71,642,114, forward strandMARVELD3PHLPP2: 71,637,834–71,724,701, reverse strandPHLPP2AP1G1: 71,729,000–71,809,201, reverse strandAP1G1ATXN1L: 71,808,439–71,885,268, forward strandATXN1LIST1: 71,845,970–71,931,199, forward strandIST1ZNF821: 71,859,676–71,895,336, reverse strandZNF821PKD1L3: 71,929,538–72,000,402, reverse strandPKD1L3DHODH: 72,008,744–72,027,659, forward strandDHODH: 72,038,099–72,093,557, reverse strandHP: 72,054,478–72,061,071, forward strandHPHPR: 72,063,148–72,077,246, forward strandHPRTXNL4B: 72,084,853–72,094,431, reverse strandTXNL4BDHX38: 72,093,613–72,112,912, forward strandDHX38PMFBP1: 72,111,574–72,176,878, reverse strandPMFBP1Diagram of DHODH: 9 exons on the forward strand of chromosome 16Exon 1: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 3: 2 known disease-causing sitesExon 7: 2 known disease-causing sitesExon 8: 2 known disease-causing sitesExon 9: 1 known disease-causing siteExon 1: 72,008,744–72,008,785, 42 basesExon 2: 72,012,050–72,012,262, 213 basesExon 3: 72,014,473–72,014,672, 200 basesExon 4: 72,017,024–72,017,106, 83 basesExon 5: 72,021,124–72,021,311, 188 basesExon 6: 72,022,362–72,022,475, 114 basesExon 7: 72,023,165–72,023,318, 154 basesExon 8: 72,023,474–72,023,633, 160 basesExon 9: 72,024,145–72,027,659, 3,515 bases1234567895′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.7 kb of the gene's 18.9 kb; 1,188 of those bases code for the protein.

How a genome test reads DHODH

9

positions in DHODH where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 18.9 kb of DHODH, introns included, not only the 4.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DHODH gene: dihydroorotate dehydrogenase (quinone). Retrieved 16 October 2026, from https://dantelabs.com/genes/dhodh

Vancouver

Dante Labs. DHODH gene: dihydroorotate dehydrogenase (quinone) [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/dhodh

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