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Gene

NONO

non-POU domain containing octamer binding

Summary

Cytogenetic location
Xq13.1
Coordinates
Chromosome X: 71,283,635–71,301,168 (GRCh38)
Exons
12 exons across 17.5 kb
Protein
471 amino acids
Also known as
p54(NRB), NRB54, NMT55, P54NRB, P54, PPP1R114
MANE Select transcript
ENST00000276079.13NM_007363.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Intellectual Disability

      • One of 233 genes linked to it

        • ClinGen rates the link definitive
        • 4 GenCC submitters rate it definitive or strong

    How NONO is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome X, with a bracket where NONO sits. NONO and 19 genes near it on chromosome X, from 70,792,402 to 71,792,401.Chromosome XXq13.1p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q2870.8 Mb71 Mb71.2 Mb71.4 Mb71.6 MbTEX11: 70,528,940–70,908,711, reverse strandTEX11SLC7A3: 70,925,556–70,931,149, reverse strandSLC7A3SNX12: 70,963,111–71,073,426, reverse strandSNX12FOXO4: 71,095,839–71,103,535, forward strandCXorf65: 71,103,889–71,106,788, reverse strandCXorf65: 71,103,987–71,111,575, reverse strandIL2RG: 71,107,404–71,112,108, reverse strandIL2RGMED12: 71,118,543–71,144,103, forward strandMED12NLGN3: 71,143,286–71,175,306, forward strandNLGN3GJB1: 71,212,811–71,225,519, forward strandGJB1ZMYM3: 71,239,617–71,255,269, reverse strandZMYM3NONO: 71,283,635–71,301,168, forward strandNONOITGB1BP2: 71,301,717–71,305,371, forward strandITGB1BP2TAF1: 71,366,129–71,532,374, forward strandTAF1OGT: 71,533,068–71,575,892, forward strandOGTGCNA: 71,578,436–71,613,590, forward strandGCNACXCR3: 71,615,912–71,618,545, reverse strandCXCR3CXorf49C: 71,667,542–71,671,527, forward strandCXorf49CCXorf49: 71,714,369–71,718,307, reverse strandCXorf49CXorf49B: 71,763,321–71,767,204, forward strandCXorf49BDiagram of NONO: 12 exons on the forward strand of chromosome XExon 3: 1 known disease-causing siteExon 4: 8 known disease-causing sitesExon 5: 2 known disease-causing sitesExon 6: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 11: 2 known disease-causing sitesExon 12: 1 known disease-causing siteExon 1: 71,283,635–71,283,721, 87 basesExon 2: 71,284,397–71,284,453, 57 basesExon 3: 71,290,629–71,290,791, 163 basesExon 4: 71,291,779–71,291,972, 194 basesExon 5: 71,294,227–71,294,528, 302 basesExon 6: 71,296,565–71,296,660, 96 basesExon 7: 71,296,851–71,297,047, 197 basesExon 8: 71,297,377–71,297,461, 85 basesExon 9: 71,297,836–71,297,938, 103 basesExon 10: 71,298,469–71,298,508, 40 basesExon 11: 71,298,707–71,298,816, 110 basesExon 12: 71,299,942–71,301,168, 1,227 bases1246810125′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 2.7 kb of the gene's 17.5 kb; 1,416 of those bases code for the protein.

    How a genome test reads NONO

    19

    positions in NONO where ClinVar classes a change as pathogenic or likely pathogenic

    4 of them (21%) fall in regions short reads find hard.

    • Low mappability (4 sites)Regions where 100 bp or 250 bp reads cannot be placed uniquely.

    A whole genome covers all 17.5 kb of NONO, introns included, not only the 2.7 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). NONO gene: non-POU domain containing octamer binding. Retrieved 16 October 2026, from https://dantelabs.com/genes/nono

    Vancouver

    Dante Labs. NONO gene: non-POU domain containing octamer binding [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/nono

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