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Gene

CNOT3

CCR4-NOT transcription complex subunit 3

Summary

Cytogenetic location
19q13.42
Coordinates
Chromosome 19: 54,137,762–54,155,681 (GRCh38)
Exons
18 exons across 17.9 kb
Protein
753 amino acids
Also known as
NOT3H, KIAA0691, LENG2
Previous symbols
NOT3
MANE Select transcript
ENST00000221232.11NM_014516.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads CNOT3 yet. The test sequences your whole genome, so your data includes it all the same.

How CNOT3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 19, with a bracket where CNOT3 sits. CNOT3 and 33 genes near it on chromosome 19, from 53,646,722 to 54,646,721.Chromosome 1919q13.42p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4353.8 Mb54 Mb54.2 Mb54.4 Mb54.6 MbNLRP12: 53,792,139–53,824,403, reverse strandNLRP12MYADM: 53,864,763–53,878,125, forward strandMYADMPRKCG: 53,879,190–53,907,652, forward strandPRKCGCACNG7: 53,909,264–53,943,950, forward strandCACNG7CACNG8: 53,962,937–53,990,215, forward strandCACNG8CACNG6: 53,991,605–54,012,670, forward strandCACNG6VSTM1: 54,040,825–54,063,959, reverse strandVSTM1TARM1: 54,069,895–54,081,365, reverse strandOSCAR: 54,094,668–54,102,692, reverse strandOSCARNDUFA3: 54,102,728–54,111,522, forward strandTFPT: 54,107,015–54,115,666, reverse strandTFPTPRPF31: 54,115,410–54,131,719, forward strandPRPF31CNOT3: 54,137,762–54,155,681, forward strandCNOT3LENG1: 54,155,161–54,159,760, reverse strandLENG1TMC4: 54,160,095–54,173,250, reverse strandTMC4MBOAT7: 54,173,412–54,189,882, reverse strandTSEN34: 54,188,464–54,194,538, forward strandTSEN34RPS9: 54,200,466–54,249,003, forward strandRPS9LILRB3: 54,215,940–54,223,506, reverse strandLILRB3LILRA6: 54,236,590–54,242,820, reverse strandLILRA6LILRB5: 54,249,421–54,257,339, reverse strandLILRB5LILRB2: 54,273,812–54,281,184, reverse strandLILRA5: 54,307,037–54,313,177, reverse strandLILRA5LILRA4: 54,333,185–54,339,162, reverse strandLILRA4LAIR1: 54,351,384–54,370,558, reverse strandLAIR1TTYH1: 54,415,219–54,436,904, forward strandTTYH1LENG8: 54,449,157–54,462,022, forward strandLENG8LENG9: 54,461,732–54,463,778, reverse strandLENG9CDC42EP5: 54,465,026–54,473,316, reverse strandCDC42EP5LAIR2: 54,497,879–54,510,694, forward strandLAIR2LILRA2: 54,572,920–54,590,287, forward strandLILRA2LILRA1: 54,593,582–54,603,259, forward strandLILRA1LILRB1: 54,616,309–54,638,022, forward strandLILRB1LILRB4: 54,643,889–54,670,531, forward strandLILRB4Diagram of CNOT3: 18 exons on the forward strand of chromosome 19Exon 2: 2 known disease-causing sitesExon 3: 3 known disease-causing sitesExon 4: 1 known disease-causing siteExon 5: 3 known disease-causing sitesExon 6: 2 known disease-causing sitesExon 7: 1 known disease-causing siteExon 8: 2 known disease-causing sitesExon 9: 2 known disease-causing sitesExon 11: 8 known disease-causing sitesExon 12: 2 known disease-causing sitesExon 13: 2 known disease-causing sitesExon 14: 1 known disease-causing siteExon 15: 4 known disease-causing sitesExon 17: 3 known disease-causing sitesExon 18: 3 known disease-causing sitesExon 1: 54,137,762–54,137,993, 232 basesExon 2: 54,142,929–54,143,003, 75 basesExon 3: 54,143,119–54,143,186, 68 basesExon 4: 54,143,442–54,143,516, 75 basesExon 5: 54,143,660–54,143,749, 90 basesExon 6: 54,144,006–54,144,134, 129 basesExon 7: 54,144,237–54,144,332, 96 basesExon 8: 54,145,598–54,145,817, 220 basesExon 9: 54,145,910–54,146,043, 134 basesExon 10: 54,146,601–54,146,657, 57 basesExon 11: 54,148,148–54,148,535, 388 basesExon 12: 54,148,620–54,148,743, 124 basesExon 13: 54,149,560–54,149,758, 199 basesExon 14: 54,152,226–54,152,325, 100 basesExon 15: 54,152,428–54,152,626, 199 basesExon 16: 54,152,867–54,152,999, 133 basesExon 17: 54,153,715–54,153,840, 126 basesExon 18: 54,155,309–54,155,681, 373 bases1246810121416185′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.8 kb of the gene's 17.9 kb; 2,262 of those bases code for the protein.

How a genome test reads CNOT3

47

positions in CNOT3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 17.9 kb of CNOT3, introns included, not only the 2.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CNOT3 gene: CCR4-NOT transcription complex subunit 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/cnot3

Vancouver

Dante Labs. CNOT3 gene: CCR4-NOT transcription complex subunit 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/cnot3

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