Gene
BCR
BCR activator of RhoGEF and GTPase
- HGNC 1014↗(opens in a new tab)
- Ensembl gene ENSG00000186716↗(opens in a new tab)
- NCBI Gene 613↗(opens in a new tab)
Summary
- Cytogenetic location
- 22q11.23
- Coordinates
- Chromosome 22: 23,180,509–23,318,037 (GRCh38)
- Exons
- 23 exons across 137.5 kb
- Protein
- 1,271 amino acids
- Also known as
- D22S662, CML, PHL, ALL
- Previous symbols
- D22S11, BCR1
- MANE Select transcript
- ENST00000305877.13NM_004327.4
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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How BCR is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 6.8 kb of the gene's 137.5 kb; 3,816 of those bases code for the protein.
Traits linked to BCR
The Human Phenotype Ontology lists these as features of the rare conditions BCR can cause. Each trait's page lists the other genes linked to it.
Abnormality of limbs
- Curvature of little finger
- Dropped arches
- Bowing of the long bones
- Coxa valga
- Finger bends toward pinky
- Fused toes
- Gap between 1st and 2nd toes
- Long slender fingers
Show 3 more traits
Abnormality of blood and blood-forming tissues
- Myeloproliferative disorder
- Abnormal basophil morphology
- Abnormal granulocyte morphology
- Abnormality of blood and blood-forming tissues
- Elevated white blood count
- Increased number of platelets in blood
- Low platelet count
- Acute lymphoblastic leukemia
Show 2 more traits
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
Cite this page
Dante Labs. (n.d.). BCR gene: BCR activator of RhoGEF and GTPase. Retrieved 17 October 2026, from https://dantelabs.com/genes/bcr
Dante Labs. BCR gene: BCR activator of RhoGEF and GTPase [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/bcr
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