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Gene

NGF

nerve growth factor

Summary

Cytogenetic location
1p13.2
Coordinates
Chromosome 1: 115,285,917–115,338,249 (GRCh38)
Exons
3 exons across 52.3 kb
Protein
241 amino acids
Previous symbols
NGFB
MANE Select transcript
ENST00000369512.3NM_002506.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hereditary Sensory and Autonomic Neuropathies (incl. Familial Dysautonomia)

    • Hereditary Sensory and Autonomic Neuropathy

      A group of neuropathies, including familial dysautonomia (ELP1), HSAN1 (SPTLC1/SPTLC2), HSAN2 (WNK1, RETREG1) and congenital insensitivity to pain (NTRK1, SCN9A, PRDM12), most of which are recessive while HSAN1 is dominant.

      • ClinGen rates the link strong
      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Protection against unnoticed injuries, burns and infections, management of autonomic symptoms, and carrier testing for relatives (familial dysautonomia is included in Ashkenazi Jewish carrier screening).

How NGF is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 1, with a bracket where NGF sits. NGF and 5 genes near it on chromosome 1, from 114,812,083 to 115,812,082.Chromosome 11p13.2p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44115 Mb115.2 Mb115.4 Mb115.6 Mb115.8 MbSYCP1: 114,854,836–114,995,370, forward strandSYCP1TSHB: 115,029,826–115,034,302, forward strandTSHBTSPAN2: 115,047,056–115,089,528, reverse strandTSPAN2NGF: 115,285,917–115,338,249, reverse strandNGFVANGL1: 115,641,854–115,698,224, forward strandVANGL1CASQ2: 115,697,988–115,837,921, reverse strandCASQ2Diagram of NGF: 3 exons on the reverse strand of chromosome 1Exon 3: 2 known disease-causing sitesExon 3: 115,285,917–115,286,807, 891 basesExon 2: 115,293,627–115,293,750, 124 basesExon 1: 115,338,204–115,338,249, 46 bases3215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.1 kb of the gene's 52.3 kb; 726 of those bases code for the protein.

How a genome test reads NGF

2

positions in NGF where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 52.3 kb of NGF, introns included, not only the 1.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). NGF gene: nerve growth factor. Retrieved 16 October 2026, from https://dantelabs.com/genes/ngf

Vancouver

Dante Labs. NGF gene: nerve growth factor [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/ngf

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