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Gene

DDR2

discoidin domain receptor tyrosine kinase 2

Summary

Cytogenetic location
1q23.3
Coordinates
Chromosome 1: 162,632,464–162,787,405 (GRCh38)
Exons
18 exons across 154.9 kb
Protein
855 amino acids
Also known as
TKT
Previous symbols
TYRO10, NTRKR3
MANE Select transcript
ENST00000367921.8NM_006182.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads DDR2 yet. The test sequences your whole genome, so your data includes it all the same.

How DDR2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where DDR2 sits. DDR2 and 11 genes near it on chromosome 1, from 162,209,935 to 163,209,934.Chromosome 11q23.3p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44162.4 Mb162.6 Mb162.8 Mb163 Mb163.2 MbNOS1AP: 162,069,676–162,370,475, forward strand: 162,365,407–162,383,531, forward strandSPATA46: 162,373,203–162,376,874, reverse strandSPATA46C1orf226: 162,378,841–162,386,812, forward strandC1orf226SH2D1B: 162,395,164–162,412,138, reverse strandSH2D1BUHMK1: 162,497,251–162,529,631, forward strandUHMK1UAP1: 162,561,476–162,616,939, forward strandUAP1DDR2: 162,632,464–162,787,405, forward strandDDR2HSD17B7: 162,790,522–162,814,371, forward strandHSD17B7CCDC190: 162,824,458–162,868,957, reverse strandCCDC190RGS4: 163,068,775–163,076,802, forward strandRGS4RGS5: 163,111,121–163,321,791, reverse strandRGS5Diagram of DDR2: 18 exons on the forward strand of chromosome 1Exon 14: 1 known disease-causing siteExon 16: 2 known disease-causing sitesExon 17: 1 known disease-causing siteExon 18: 1 known disease-causing siteExon 1: 162,632,464–162,632,631, 168 basesExon 2: 162,655,211–162,655,374, 164 basesExon 3: 162,719,037–162,719,145, 109 basesExon 4: 162,753,095–162,753,197, 103 basesExon 5: 162,754,624–162,754,855, 232 basesExon 6: 162,755,156–162,755,303, 148 basesExon 7: 162,755,664–162,755,769, 106 basesExon 8: 162,759,796–162,759,979, 184 basesExon 9: 162,761,211–162,761,454, 244 basesExon 10: 162,766,001–162,766,063, 63 basesExon 11: 162,767,229–162,767,359, 131 basesExon 12: 162,770,302–162,770,512, 211 basesExon 13: 162,772,024–162,772,247, 224 basesExon 14: 162,773,469–162,773,596, 128 basesExon 15: 162,775,652–162,775,843, 192 basesExon 16: 162,776,136–162,776,370, 235 basesExon 17: 162,778,580–162,778,729, 150 basesExon 18: 162,780,112–162,787,405, 7,294 bases151015185′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 10.1 kb of the gene's 154.9 kb; 2,568 of those bases code for the protein.

How a genome test reads DDR2

5

positions in DDR2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 154.9 kb of DDR2, introns included, not only the 10.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DDR2 gene: discoidin domain receptor tyrosine kinase 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/ddr2

Vancouver

Dante Labs. DDR2 gene: discoidin domain receptor tyrosine kinase 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/ddr2

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