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Gene

IPO8

importin 8

Summary

Cytogenetic location
12p11.21
Coordinates
Chromosome 12: 30,628,988–30,695,869 (GRCh38)
Exons
25 exons across 66.9 kb
Protein
1,037 amino acids
Also known as
IMP8
Previous symbols
RANBP8
MANE Select transcript
ENST00000256079.9NM_006390.4
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads IPO8 yet. The test sequences your whole genome, so your data includes it all the same.

How IPO8 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where IPO8 sits. IPO8 and 3 genes near it on chromosome 12, from 30,162,429 to 31,162,428.Chromosome 1212p11.21p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3330.2 Mb30.4 Mb30.6 Mb30.8 Mb31 MbIPO8: 30,628,988–30,695,869, reverse strandIPO8CAPRIN2: 30,709,508–30,823,302, reverse strandCAPRIN2TSPAN11: 30,926,428–30,996,602, forward strandTSPAN11DDX11: 31,073,282–31,104,811, forward strandDDX11Diagram of IPO8: 25 exons on the reverse strand of chromosome 12Exon 22: 2 known disease-causing sitesExon 21: 2 known disease-causing sitesExon 20: 1 known disease-causing siteExon 19: 1 known disease-causing siteExon 17: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 1: 1 known disease-causing siteExon 25: 30,628,988–30,630,957, 1,970 basesExon 24: 30,631,895–30,632,011, 117 basesExon 23: 30,634,083–30,634,286, 204 basesExon 22: 30,636,982–30,637,187, 206 basesExon 21: 30,639,515–30,639,735, 221 basesExon 20: 30,649,137–30,649,232, 96 basesExon 19: 30,652,192–30,652,289, 98 basesExon 18: 30,652,967–30,653,092, 126 basesExon 17: 30,656,684–30,656,750, 67 basesExon 16: 30,661,141–30,661,266, 126 basesExon 15: 30,662,327–30,662,487, 161 basesExon 14: 30,663,489–30,663,654, 166 basesExon 13: 30,665,220–30,665,309, 90 basesExon 12: 30,665,729–30,665,845, 117 basesExon 11: 30,666,175–30,666,251, 77 basesExon 10: 30,669,183–30,669,282, 100 basesExon 9: 30,670,962–30,671,096, 135 basesExon 8: 30,673,990–30,674,074, 85 basesExon 7: 30,674,659–30,674,753, 95 basesExon 6: 30,676,498–30,676,587, 90 basesExon 5: 30,680,482–30,680,638, 157 basesExon 4: 30,681,659–30,681,817, 159 basesExon 3: 30,684,301–30,684,457, 157 basesExon 2: 30,690,496–30,690,577, 82 basesExon 1: 30,695,564–30,695,869, 306 bases252422201816141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.2 kb of the gene's 66.9 kb; 3,114 of those bases code for the protein.

Sequencing IPO8

1Low

How hard IPO8 is to sequence with short reads, out of 100

  • Mappability0%
  • Homology0%
  • Repeats2.5%
  • GC content3.2%
  • Reference coverage0%

15

positions in IPO8 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 66.9 kb of IPO8, introns included, not only the 5.2 kb of exons.

Traits linked to IPO8

The Human Phenotype Ontology lists these as features of the rare conditions IPO8 can cause. Each trait's page lists the other genes linked to it.

Abnormality of the cardiovascular system

Show 21 more traits

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Genome in a Bottle genome stratifications, from NIST: the sequencing difficulty score.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). IPO8 gene: importin 8. Retrieved 17 October 2026, from https://dantelabs.com/genes/ipo8

Vancouver

Dante Labs. IPO8 gene: importin 8 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/ipo8

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