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Gene

TONSL

tonsoku like, DNA repair protein

Summary

Cytogenetic location
8q24.3
Coordinates
Chromosome 8: 144,428,775–144,444,440 (GRCh38)
Exons
26 exons across 15.7 kb
Protein
1,378 amino acids
Also known as
IKBR
Previous symbols
NFKBIL2
MANE Select transcript
ENST00000409379.8NM_013432.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads TONSL yet. The test sequences your whole genome, so your data includes it all the same.

How TONSL is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 8, with a bracket where TONSL sits. TONSL and 48 genes near it on chromosome 8, from 143,936,608 to 144,936,607.Chromosome 88q24.3p23.3p23.2p23.1p22p21.3p21.2p21.1p12p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.3q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.3144 Mb144.2 Mb144.4 Mb144.6 Mb144.8 MbPLEC: 143,915,152–143,977,039, reverse strandPLECPARP10: 143,977,151–144,019,930, reverse strandPARP10GRINA: 143,990,048–143,994,935, forward strandGRINASPATC1: 144,012,275–144,047,114, forward strandSPATC1OPLAH: 144,051,265–144,064,091, reverse strandEXOSC4: 144,078,560–144,081,408, forward strand: 144,078,642–144,084,330, forward strandGPAA1: 144,082,337–144,093,149, forward strandCYC1: 144,095,039–144,097,525, forward strandSHARPIN: 144,097,513–144,108,124, reverse strandSHARPINMAF1: 144,103,112–144,107,618, forward strandMAF1WDR97: 144,107,726–144,118,328, forward strandWDR97HGH1: 144,137,774–144,140,851, forward strandHGH1MROH1: 144,147,975–144,262,470, forward strandMROH1BOP1: 144,262,045–144,291,453, reverse strandBOP1SCX: 144,266,446–144,268,481, forward strandSCXHSF1: 144,291,521–144,314,729, forward strandHSF1DGAT1: 144,314,584–144,326,916, reverse strandSCRT1: 144,330,565–144,336,503, reverse strandSLC52A2: 144,333,957–144,361,447, forward strandSLC52A2CATSPERQ: 144,352,219–144,354,954, reverse strandCATSPERQ: 144,353,228–144,355,609, reverse strandFBXL6: 144,355,427–144,359,376, reverse strandFBXL6ADCK5: 144,373,101–144,393,243, forward strandCPSF1: 144,393,229–144,409,864, reverse strandSLC39A4: 144,409,742–144,416,894, reverse strandVPS28: 144,423,597–144,429,499, reverse strandVPS28TONSL: 144,428,775–144,444,440, reverse strandTONSLZFTRAF1: 144,447,345–144,462,908, reverse strandZFTRAF1TMEM276-ZFTRAF1: 144,449,582–144,465,430, reverse strandTMEM276-ZFTRAF1TMEM276: 144,463,817–144,466,890, reverse strandKIFC2: 144,465,940–144,474,202, forward strandFOXH1: 144,473,412–144,475,873, reverse strandPPP1R16A: 144,475,989–144,502,126, forward strandGPT: 144,502,608–144,507,494, forward strandGPTSLC33A2: 144,508,263–144,511,317, forward strandRECQL4: 144,511,284–144,517,890, reverse strandLRRC14: 144,517,957–144,526,244, forward strandLRRC24: 144,522,385–144,527,608, reverse strandC8orf82: 144,525,733–144,529,132, reverse strandARHGAP39: 144,529,179–144,685,879, reverse strandZNF251: 144,720,515–144,756,417, reverse strandZNF251ZNF34: 144,770,441–144,788,684, reverse strandZNF34RPL8: 144,789,765–144,793,502, reverse strandRPL8ZNF517: 144,798,863–144,813,034, forward strandZNF517ZNF7: 144,826,894–144,848,546, forward strandZNF7COMMD5: 144,837,760–144,854,229, reverse strandCOMMD5ZNF250: 144,876,497–144,902,217, reverse strandZNF250ZNF16: 144,929,355–144,950,888, reverse strandZNF16Diagram of TONSL: 26 exons on the reverse strand of chromosome 8Exon 26: 1 known disease-causing siteExon 22: 1 known disease-causing siteExon 21: 2 known disease-causing sitesExon 19: 1 known disease-causing siteExon 18: 1 known disease-causing siteExon 17: 4 known disease-causing sitesExon 16: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 11: 3 known disease-causing sitesExon 6: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 26: 144,428,775–144,429,336, 562 basesExon 25: 144,430,404–144,430,537, 134 basesExon 24: 144,431,078–144,431,151, 74 basesExon 23: 144,432,285–144,432,460, 176 basesExon 22: 144,433,588–144,433,759, 172 basesExon 21: 144,433,978–144,434,279, 302 basesExon 20: 144,434,811–144,434,889, 79 basesExon 19: 144,435,017–144,435,170, 154 basesExon 18: 144,435,474–144,435,550, 77 basesExon 17: 144,435,658–144,436,418, 761 basesExon 16: 144,436,558–144,436,681, 124 basesExon 15: 144,436,757–144,436,920, 164 basesExon 14: 144,437,027–144,437,099, 73 basesExon 13: 144,438,471–144,438,560, 90 basesExon 12: 144,438,653–144,438,735, 83 basesExon 11: 144,440,021–144,440,210, 190 basesExon 10: 144,440,351–144,440,476, 126 basesExon 9: 144,440,718–144,440,870, 153 basesExon 8: 144,440,966–144,441,111, 146 basesExon 7: 144,442,037–144,442,151, 115 basesExon 6: 144,442,241–144,442,412, 172 basesExon 5: 144,442,677–144,442,806, 130 basesExon 4: 144,443,138–144,443,321, 184 basesExon 3: 144,443,882–144,444,024, 143 basesExon 2: 144,444,180–144,444,275, 96 basesExon 1: 144,444,390–144,444,440, 51 bases2625201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.5 kb of the gene's 15.7 kb; 4,137 of those bases code for the protein.

How a genome test reads TONSL

22

positions in TONSL where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 15.7 kb of TONSL, introns included, not only the 4.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TONSL gene: tonsoku like, DNA repair protein. Retrieved 16 October 2026, from https://dantelabs.com/genes/tonsl

Vancouver

Dante Labs. TONSL gene: tonsoku like, DNA repair protein [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tonsl

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