Skip to content
Use your HSA or FSA funds

Gene

BGN

biglycan

Summary

Cytogenetic location
Xq28
Coordinates
Chromosome X: 153,494,980–153,509,546 (GRCh38)
Exons
8 exons across 14.6 kb
Protein
368 amino acids
Inheritance
X-linked recessive
Also known as
DSPG1, SLRR1A
MANE Select transcript
ENST00000331595.9NM_001711.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Marfan Like Syndromes

    • Meester-Loeys syndromeX-linked recessive

      BGN-related aortic aneurysm and dissection with joint and skeletal features, mainly in males.

      • ClinGen rates the link strong
      • 3 GenCC submitters rate it definitive or strong

Inheritance

X-linked recessive
The change is on the X chromosome, so one copy affects males, who have one X, while females with one are usually carriers. A carrier mother passes it on to each child with a one-in-two chance.

How BGN is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome X, with a bracket where BGN sits. BGN and 30 genes near it on chromosome X, from 153,002,263 to 154,002,262.Chromosome XXq28p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q28153.2 Mb153.4 Mb153.6 Mb153.8 Mb154 MbPNMA3: 153,056,409–153,060,467, forward strandPNMA3PNMA6A: 153,072,454–153,075,019, forward strandPNMA6AMAGEA1: 153,179,284–153,183,880, forward strandMAGEA1PWWP4: 153,266,152–153,279,145, forward strandPWWP4PNMA6F: 153,317,680–153,321,774, reverse strandPNMA6FZNF275: 153,334,122–153,360,110, forward strandZNF275PNMA6E: 153,395,639–153,401,392, reverse strandPNMA6EZFP92: 153,411,434–153,426,481, forward strandZFP92TREX2: 153,444,473–153,470,592, reverse strandTREX2HAUS7: 153,447,655–153,495,529, reverse strandHAUS7BGN: 153,494,980–153,509,546, forward strandBGNATP2B3: 153,517,620–153,582,939, forward strandATP2B3CCNQ: 153,587,925–153,600,045, reverse strandCCNQDUSP9: 153,642,397–153,651,326, forward strandDUSP9PNCK: 153,669,730–153,689,033, reverse strandPNCKSLC6A8: 153,687,914–153,696,591, forward strandSLC6A8BCAP31: 153,698,006–153,725,957, reverse strandBCAP31ABCD1: 153,724,495–153,744,755, forward strandABCD1PLXNB3: 153,764,179–153,779,346, forward strandPLXNB3SRPK3: 153,781,001–153,785,768, forward strandSRPK3IDH3G: 153,785,735–153,794,535, reverse strandIDH3GSSR4: 153,793,516–153,798,510, forward strandSSR4PDZD4: 153,802,161–153,830,935, reverse strandL1CAM: 153,861,511–153,886,204, reverse strandL1CAM: 153,872,221–153,909,223, reverse strandAVPR2: 153,902,531–153,907,169, forward strandAVPR2ARHGAP4: 153,907,367–153,934,999, reverse strandARHGAP4NAA10: 153,928,799–153,935,083, reverse strandNAA10RENBP: 153,935,269–153,944,688, reverse strandHCFC1: 153,946,434–153,972,427, reverse strandHCFC1TMEM187: 153,972,290–153,983,194, forward strandDiagram of BGN: 8 exons on the forward strand of chromosome XExon 2: 6 known disease-causing sitesExon 4: 2 known disease-causing sitesExon 5: 1 known disease-causing siteExon 1: 153,494,980–153,495,113, 134 basesExon 2: 153,504,621–153,504,869, 249 basesExon 3: 153,505,238–153,505,350, 113 basesExon 4: 153,505,863–153,506,076, 214 basesExon 5: 153,506,529–153,506,639, 111 basesExon 6: 153,506,830–153,506,923, 94 basesExon 7: 153,507,047–153,507,185, 139 basesExon 8: 153,508,248–153,509,546, 1,299 bases123456785′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.4 kb of the gene's 14.6 kb; 1,107 of those bases code for the protein.

How a genome test reads BGN

12

positions in BGN where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 14.6 kb of BGN, introns included, not only the 2.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). BGN gene: biglycan. Retrieved 16 October 2026, from https://dantelabs.com/genes/bgn

Vancouver

Dante Labs. BGN gene: biglycan [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/bgn

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test