Skip to content
Use your HSA or FSA funds

Gene

COG4

component of oligomeric golgi complex 4

Summary

Cytogenetic location
16q22.1
Coordinates
Chromosome 16: 70,480,571–70,523,554 (GRCh38)
Exons
19 exons across 43 kb
Protein
789 amino acids
Also known as
COD1, DKFZP586E1519
MANE Select transcript
ENST00000323786.10NM_015386.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Congenital Disorders of Glycosylation

      • Congenital Disorders of Glycosylation (CDG)

        One of 98 genes linked to it

        A large group of inherited conditions in which sugar chains (glycans) are not correctly built or attached to proteins and lipids, often affecting the brain, liver, blood clotting, growth and many other body systems. Most are autosomal recessive, but some are X-linked or autosomal dominant.

        • ClinGen rates the link moderate
        • 2 GenCC submitters rate it definitive or strong

    How COG4 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 16, with a bracket where COG4 sits. COG4 and 14 genes near it on chromosome 16, from 70,002,063 to 71,002,062.Chromosome 1616q22.1p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.370.2 Mb70.4 Mb70.6 Mb70.8 Mb71 MbPDPR: 70,114,225–70,162,537, forward strandPDPRCLEC18C: 70,173,322–70,187,361, forward strandCLEC18CEXOSC6: 70,246,778–70,251,940, reverse strandEXOSC6AARS1: 70,251,983–70,289,707, reverse strandAARS1DDX19B: 70,289,663–70,335,992, forward strandDDX19B: 70,299,194–70,372,582, forward strandDDX19A: 70,346,861–70,379,987, forward strandDDX19AST3GAL2: 70,375,977–70,439,263, reverse strandST3GAL2FCSK: 70,454,398–70,480,275, forward strandFCSKCOG4: 70,480,571–70,523,554, reverse strandCOG4SF3B3: 70,523,782–70,577,670, forward strandSF3B3IL34: 70,579,868–70,661,556, forward strandIL34MTSS2: 70,661,204–70,686,086, reverse strandMTSS2VAC14: 70,687,436–70,801,178, reverse strandVAC14HYDIN: 70,802,084–71,230,735, reverse strandHYDINDiagram of COG4: 19 exons on the reverse strand of chromosome 16Exon 17: 1 known disease-causing siteExon 16: 1 known disease-causing siteExon 15: 1 known disease-causing siteExon 12: 2 known disease-causing sitesExon 11: 1 known disease-causing siteExon 10: 2 known disease-causing sitesExon 9: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 7: 3 known disease-causing sitesExon 5: 1 known disease-causing siteExon 4: 2 known disease-causing sitesExon 3: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 1: 2 known disease-causing sitesExon 19: 70,480,571–70,481,144, 574 basesExon 18: 70,481,359–70,481,487, 129 basesExon 17: 70,481,764–70,481,865, 102 basesExon 16: 70,482,092–70,482,175, 84 basesExon 15: 70,482,729–70,482,821, 93 basesExon 14: 70,483,853–70,483,969, 117 basesExon 13: 70,490,330–70,490,392, 63 basesExon 12: 70,496,266–70,496,431, 166 basesExon 11: 70,497,221–70,497,387, 167 basesExon 10: 70,497,937–70,498,055, 119 basesExon 9: 70,500,958–70,501,091, 134 basesExon 8: 70,508,406–70,508,464, 59 basesExon 7: 70,509,231–70,509,388, 158 basesExon 6: 70,509,916–70,510,021, 106 basesExon 5: 70,512,239–70,512,432, 194 basesExon 4: 70,514,335–70,514,509, 175 basesExon 3: 70,517,626–70,517,740, 115 basesExon 2: 70,519,649–70,519,731, 83 basesExon 1: 70,523,373–70,523,554, 182 bases191510515′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 2.8 kb of the gene's 43 kb; 2,370 of those bases code for the protein.

    How a genome test reads COG4

    25

    positions in COG4 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 43 kb of COG4, introns included, not only the 2.8 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). COG4 gene: component of oligomeric golgi complex 4. Retrieved 16 October 2026, from https://dantelabs.com/genes/cog4

    Vancouver

    Dante Labs. COG4 gene: component of oligomeric golgi complex 4 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/cog4

    One test. A lifetime of answers.

    From $449Free shipping · Results in 6–8 weeks

    Get my Genome Test