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Gene

ACSL4

acyl-CoA synthetase long chain family member 4

Summary

Cytogenetic location
Xq23
Coordinates
Chromosome X: 109,641,335–109,733,257 (GRCh38)
Exons
16 exons across 91.9 kb
Protein
670 amino acids
Also known as
ACS4, LACS4
Previous symbols
FACL4, MRX63, MRX68
MANE Select transcript
ENST00000672401.1NM_001318510.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Intellectual Disability

      • One of 233 genes linked to it

        • ClinGen rates the link definitive
        • 4 GenCC submitters rate it definitive or strong

    How ACSL4 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome X, with a bracket where ACSL4 sits. ACSL4 and 4 genes near it on chromosome X, from 109,187,296 to 110,187,295.Chromosome XXq23p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q28109.2 Mb109.4 Mb109.6 Mb109.8 Mb110 MbGUCY2F: 109,372,906–109,482,086, reverse strandGUCY2FNXT2: 109,535,776–109,544,811, forward strandNXT2KCNE5: 109,623,700–109,625,172, reverse strandKCNE5ACSL4: 109,641,335–109,733,257, reverse strandACSL4TMEM164: 110,002,631–110,334,219, forward strandTMEM164Diagram of ACSL4: 16 exons on the reverse strand of chromosome XExon 15: 1 known disease-causing siteExon 14: 2 known disease-causing sitesExon 11: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 16: 109,641,335–109,644,186, 2,852 basesExon 15: 109,659,354–109,659,511, 158 basesExon 14: 109,661,531–109,661,645, 115 basesExon 13: 109,663,211–109,663,402, 192 basesExon 12: 109,665,420–109,665,494, 75 basesExon 11: 109,668,101–109,668,273, 173 basesExon 10: 109,669,034–109,669,173, 140 basesExon 9: 109,674,402–109,674,473, 72 basesExon 8: 109,677,988–109,678,111, 124 basesExon 7: 109,678,265–109,678,415, 151 basesExon 6: 109,680,998–109,681,136, 139 basesExon 5: 109,681,266–109,681,375, 110 basesExon 4: 109,682,719–109,682,896, 178 basesExon 3: 109,683,136–109,683,375, 240 basesExon 2: 109,696,144–109,696,196, 53 basesExon 1: 109,733,139–109,733,257, 119 bases16141210864215′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 4.9 kb of the gene's 91.9 kb; 2,013 of those bases code for the protein.

    How a genome test reads ACSL4

    8

    positions in ACSL4 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 91.9 kb of ACSL4, introns included, not only the 4.9 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). ACSL4 gene: acyl-CoA synthetase long chain family member 4. Retrieved 17 October 2026, from https://dantelabs.com/genes/acsl4

    Vancouver

    Dante Labs. ACSL4 gene: acyl-CoA synthetase long chain family member 4 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/acsl4

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