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Gene

INPPL1

inositol polyphosphate phosphatase like 1

Summary

Cytogenetic location
11q13.4
Coordinates
Chromosome 11: 72,224,767–72,239,147 (GRCh38)
Exons
28 exons across 14.4 kb
Protein
1,258 amino acids
Also known as
SHIP2
MANE Select transcript
ENST00000298229.7NM_001567.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads INPPL1 yet. The test sequences your whole genome, so your data includes it all the same.

How INPPL1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 11, with a bracket where INPPL1 sits. INPPL1 and 19 genes near it on chromosome 11, from 71,731,957 to 72,731,956.Chromosome 1111q13.4p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q2571.8 Mb72 Mb72.2 Mb72.4 Mb72.6 MbXNDC1N-ZNF705EP-ALG1L9P: 71,804,997–71,928,656, reverse strandXNDC1N-ZNF705EP-ALG1L9PDEFB108B: 71,833,200–71,837,710, forward strandDEFB108BXNDC1N: 71,865,504–71,928,917, reverse strandXNDC1NDEFB131B: 71,878,453–71,884,561, forward strandDEFB131BRNF121: 71,929,005–71,997,597, forward strandRNF121IL18BP: 71,998,613–72,007,315, forward strandIL18BPNUMA1: 72,002,860–72,080,693, reverse strandLRRC51: 72,080,286–72,096,895, forward strandLRTOMT: 72,080,331–72,110,782, forward strandLRTOMTLAMTOR1: 72,085,520–72,103,393, reverse strandTOMT: 72,103,506–72,111,546, forward strandTOMTANAPC15: 72,106,370–72,113,688, reverse strandANAPC15FOLR3: 72,114,869–72,141,085, forward strandFOLR3FOLR1: 72,189,529–72,199,329, forward strandFOLR1FOLR2: 72,216,601–72,221,957, forward strandFOLR2INPPL1: 72,224,767–72,239,147, forward strandINPPL1PHOX2A: 72,239,077–72,245,664, reverse strandPHOX2ACLPB: 72,285,495–72,434,680, reverse strandCLPBPDE2A: 72,576,141–72,674,591, reverse strandPDE2AARAP1: 72,682,436–72,794,047, reverse strandARAP1Diagram of INPPL1: 28 exons on the forward strand of chromosome 11Exon 1: 3 known disease-causing sitesExon 3: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 16: 2 known disease-causing sitesExon 17: 1 known disease-causing siteExon 21: 2 known disease-causing sitesExon 23: 1 known disease-causing siteExon 26: 2 known disease-causing sitesExon 27: 1 known disease-causing siteExon 1: 72,224,767–72,225,166, 400 basesExon 2: 72,228,190–72,228,253, 64 basesExon 3: 72,228,348–72,228,498, 151 basesExon 4: 72,228,727–72,228,847, 121 basesExon 5: 72,229,090–72,229,230, 141 basesExon 6: 72,229,465–72,229,558, 94 basesExon 7: 72,229,663–72,229,752, 90 basesExon 8: 72,229,924–72,230,019, 96 basesExon 9: 72,230,121–72,230,271, 151 basesExon 10: 72,230,362–72,230,468, 107 basesExon 11: 72,230,796–72,230,898, 103 basesExon 12: 72,230,993–72,231,189, 197 basesExon 13: 72,231,498–72,231,615, 118 basesExon 14: 72,232,240–72,232,336, 97 basesExon 15: 72,232,626–72,232,764, 139 basesExon 16: 72,232,875–72,232,974, 100 basesExon 17: 72,233,075–72,233,163, 89 basesExon 18: 72,233,441–72,233,522, 82 basesExon 19: 72,233,655–72,233,744, 90 basesExon 20: 72,234,281–72,234,394, 114 basesExon 21: 72,234,527–72,234,615, 89 basesExon 22: 72,235,116–72,235,203, 88 basesExon 23: 72,235,296–72,235,451, 156 basesExon 24: 72,235,675–72,235,753, 79 basesExon 25: 72,235,846–72,235,986, 141 basesExon 26: 72,237,124–72,237,796, 673 basesExon 27: 72,238,042–72,238,175, 134 basesExon 28: 72,238,263–72,239,147, 885 bases12468101214161820222426285′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.8 kb of the gene's 14.4 kb; 3,777 of those bases code for the protein.

How a genome test reads INPPL1

18

positions in INPPL1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 14.4 kb of INPPL1, introns included, not only the 4.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). INPPL1 gene: inositol polyphosphate phosphatase like 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/inppl1

Vancouver

Dante Labs. INPPL1 gene: inositol polyphosphate phosphatase like 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/inppl1

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