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Gene

RAB23

RAB23, member RAS oncogene family

Summary

Cytogenetic location
6p12.1-p11.2
Coordinates
Chromosome 6: 57,186,992–57,222,307 (GRCh38)
Exons
7 exons across 35.3 kb
Protein
237 amino acids
MANE Select transcript
ENST00000468148.6NM_016277.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Syndromic Craniosynostosis

    • Conditions combining early skull suture closure with other features, including Apert, Crouzon, Pfeiffer, Muenke and Saethre-Chotzen syndromes, caused by genes such as FGFR2, FGFR3, FGFR1, TWIST1, TCF12 and ERF.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Early diagnosis allows timely surgery and monitoring of head growth, vision and hearing; milder forms such as Muenke syndrome can go unrecognised in adults, which is relevant to family planning.

How RAB23 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 6, with a bracket where RAB23 sits. RAB23 and 6 genes near it on chromosome 6, from 56,704,650 to 57,704,649.Chromosome 66p12.1-p11.2p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q2756.8 Mb57 Mb57.2 Mb57.4 Mb57.6 MbDST: 56,457,981–56,955,274, reverse strandDSTBEND6: 56,954,805–57,027,980, forward strandBEND6KIAA1586: 57,046,525–57,086,397, forward strandKIAA1586ZNF451: 57,086,844–57,170,305, forward strandZNF451BAG2: 57,172,272–57,189,833, forward strandBAG2RAB23: 57,186,992–57,222,307, reverse strandRAB23PRIM2: 57,221,513–57,647,924, forward strandPRIM2Diagram of RAB23: 7 exons on the reverse strand of chromosome 6Exon 7: 1 known disease-causing siteExon 6: 4 known disease-causing sitesExon 5: 6 known disease-causing sitesExon 4: 3 known disease-causing sitesExon 3: 3 known disease-causing sitesExon 2: 7 known disease-causing sitesExon 7: 57,186,992–57,190,600, 3,609 basesExon 6: 57,193,842–57,193,934, 93 basesExon 5: 57,194,770–57,194,852, 83 basesExon 4: 57,196,450–57,196,606, 157 basesExon 3: 57,207,628–57,207,713, 86 basesExon 2: 57,210,226–57,210,445, 220 basesExon 1: 57,221,726–57,222,307, 582 bases76543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.8 kb of the gene's 35.3 kb; 714 of those bases code for the protein.

How a genome test reads RAB23

33

positions in RAB23 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 35.3 kb of RAB23, introns included, not only the 4.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). RAB23 gene: RAB23, member RAS oncogene family. Retrieved 16 October 2026, from https://dantelabs.com/genes/rab23

Vancouver

Dante Labs. RAB23 gene: RAB23, member RAS oncogene family [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/rab23

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