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Gene

SF3B4

splicing factor 3b subunit 4

Summary

Cytogenetic location
1q21.2
Coordinates
Chromosome 1: 149,923,317–149,927,803 (GRCh38)
Exons
6 exons across 4.5 kb
Protein
424 amino acids
Also known as
SAP49, SF3b49, Hsh49
MANE Select transcript
ENST00000271628.9NM_005850.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads SF3B4 yet. The test sequences your whole genome, so your data includes it all the same.

How SF3B4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where SF3B4 sits. SF3B4 and 30 genes near it on chromosome 1, from 149,425,560 to 150,425,559.Chromosome 11q21.2p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44149.6 Mb149.8 Mb150 Mb150.2 Mb150.4 MbNOTCH2NLC: 149,390,534–149,471,833, forward strandNOTCH2NLC: 149,390,623–149,556,361, forward strandNBPF19: 149,474,815–149,556,361, forward strandNBPF19PPIAL4C: 149,583,848–149,584,607, forward strandPPIAL4CFCGR1A: 149,734,951–149,792,526, forward strandFCGR1AH2BC18: 149,755,110–149,812,374, reverse strandH2BC18H3C13: 149,813,225–149,813,693, reverse strandH4C14: 149,832,657–149,839,767, forward strandH3C14: 149,840,687–149,841,208, reverse strandH3C14H2AC18: 149,842,218–149,842,750, reverse strandH2AC18H2AC19: 149,851,061–149,851,652, forward strandH3C15: 149,852,608–149,853,125, forward strandH3C15H4C15: 149,854,045–149,861,159, reverse strandH2BC21: 149,884,459–149,886,682, reverse strandBOLA1: 149,886,406–149,900,798, forward strandBOLA1H2AC20: 149,886,918–149,887,411, forward strandH2AC21: 149,887,469–149,887,965, reverse strandSV2A: 149,903,318–149,918,572, reverse strandSV2ASF3B4: 149,923,317–149,927,803, reverse strandSF3B4MTMR11: 149,928,650–149,937,534, reverse strandMTMR11OTUD7B: 149,937,812–150,010,758, reverse strandOTUD7BVPS45: 150,067,279–150,145,329, forward strandVPS45PLEKHO1: 150,149,183–150,164,720, forward strandPLEKHO1ANP32E: 150,217,463–150,236,202, reverse strandANP32ECA14: 150,257,069–150,265,078, forward strandCA14APH1A: 150,265,042–150,269,580, reverse strandAPH1AC1orf54: 150,268,034–150,281,744, forward strandC1orf54CIART: 150,282,527–150,287,093, forward strandCIARTMRPS21: 150,293,848–150,309,828, forward strandPRPF3: 150,321,476–150,353,341, forward strandPRPF3RPRD2: 150,363,091–150,476,999, forward strandRPRD2Diagram of SF3B4: 6 exons on the reverse strand of chromosome 1Exon 6: 1 known disease-causing siteExon 4: 3 known disease-causing sitesExon 3: 4 known disease-causing sitesExon 2: 1 known disease-causing siteExon 1: 2 known disease-causing sitesExon 6: 149,923,317–149,923,729, 413 basesExon 5: 149,923,841–149,924,014, 174 basesExon 4: 149,925,836–149,926,042, 207 basesExon 3: 149,926,376–149,926,918, 543 basesExon 2: 149,927,166–149,927,294, 129 basesExon 1: 149,927,726–149,927,803, 78 bases6543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.5 kb of the gene's 4.5 kb; 1,275 of those bases code for the protein.

How a genome test reads SF3B4

12

positions in SF3B4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 4.5 kb of SF3B4, introns included, not only the 1.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SF3B4 gene: splicing factor 3b subunit 4. Retrieved 17 October 2026, from https://dantelabs.com/genes/sf3b4

Vancouver

Dante Labs. SF3B4 gene: splicing factor 3b subunit 4 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/sf3b4

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