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Gene

RNU12

RNA, U12 small nuclear

Summary

Cytogenetic location
22q13.2
Coordinates
Chromosome 22: 42,615,244–42,615,393 (GRCh38)
Exons
1 exon across 0.2 kb
Also known as
RNU12-1
Previous symbols
RNU12P
MANE Select transcript
ENST00000362512.1NR_029422.2
Locus type
RNA, small nuclear

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Syndromic Craniosynostosis

    • Conditions combining early skull suture closure with other features, including Apert, Crouzon, Pfeiffer, Muenke and Saethre-Chotzen syndromes, caused by genes such as FGFR2, FGFR3, FGFR1, TWIST1, TCF12 and ERF.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Early diagnosis allows timely surgery and monitoring of head growth, vision and hearing; milder forms such as Muenke syndrome can go unrecognised in adults, which is relevant to family planning.

How RNU12 is laid out

  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 22, with a bracket where RNU12 sits. RNU12 and 15 genes near it on chromosome 22, from 42,115,319 to 43,115,318.Chromosome 2222q13.2p13p12p11.2p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.31q13.32q13.3342.2 Mb42.4 Mb42.6 Mb42.8 Mb43 MbCYP2D6: 42,120,962–42,131,727, reverse strandCYP2D6CYP2D7: 42,140,203–42,149,500, reverse strandCYP2D7TCF20: 42,160,013–42,343,616, reverse strandTCF20NFAM1: 42,380,407–42,432,425, reverse strandNFAM1RRP7A: 42,507,982–42,519,853, reverse strandRRP7ASERHL2: 42,553,617–42,574,387, forward strandSERHL2POLDIP3: 42,582,750–42,614,962, reverse strandPOLDIP3: 42,583,836–42,627,688, reverse strandRNU12: 42,615,244–42,615,393, forward strandRNU12CYB5R3: 42,615,730–42,720,870, reverse strandATP5MGL: 42,639,803–42,640,601, reverse strandATP5MGLA4GALT: 42,691,010–42,721,298, reverse strandA4GALTARFGAP3: 42,796,502–42,858,106, reverse strandARFGAP3PACSIN2: 42,835,412–43,015,185, reverse strandPACSIN2TTLL1: 43,039,447–43,089,430, reverse strandTTLL1BIK: 43,110,742–43,129,712, forward strandBIKDiagram of RNU12: one exon on the forward strand of chromosome 22Exon 1: 6 known disease-causing sitesExon 1: 42,615,244–42,615,393, 150 bases15′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 0.2 kb of the gene's 0.2 kb.

How a genome test reads RNU12

7

positions in RNU12 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 0.2 kb of RNU12, introns included, not only the 0.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). RNU12 gene: RNA, U12 small nuclear. Retrieved 17 October 2026, from https://dantelabs.com/genes/rnu12

Vancouver

Dante Labs. RNU12 gene: RNA, U12 small nuclear [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/rnu12

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