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Gene

NTRK1

neurotrophic receptor tyrosine kinase 1

Summary

Cytogenetic location
1q23.1
Coordinates
Chromosome 1: 156,860,865–156,881,850 (GRCh38)
Exons
17 exons across 21 kb
Protein
796 amino acids
Also known as
TRK, TRKA, MTC
MANE Select transcript
ENST00000524377.7NM_002529.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hereditary Sensory and Autonomic Neuropathies (incl. Familial Dysautonomia)

    • Hereditary Sensory and Autonomic Neuropathy

      A group of neuropathies, including familial dysautonomia (ELP1), HSAN1 (SPTLC1/SPTLC2), HSAN2 (WNK1, RETREG1) and congenital insensitivity to pain (NTRK1, SCN9A, PRDM12), most of which are recessive while HSAN1 is dominant.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Protection against unnoticed injuries, burns and infections, management of autonomic symptoms, and carrier testing for relatives (familial dysautonomia is included in Ashkenazi Jewish carrier screening).

How NTRK1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where NTRK1 sits. NTRK1 and 22 genes near it on chromosome 1, from 156,371,358 to 157,371,357.Chromosome 11q23.1p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44156.4 Mb156.6 Mb156.8 Mb157 Mb157.2 MbRHBG: 156,369,015–156,385,221, forward strandRHBGMEF2D: 156,463,727–156,501,266, reverse strandMEF2DIQGAP3: 156,525,405–156,572,604, reverse strandIQGAP3TTC24: 156,579,723–156,587,719, forward strandTTC24NAXE: 156,591,738–156,609,507, forward strandNAXEGPATCH4: 156,594,301–156,601,496, reverse strandGPATCH4HAPLN2: 156,619,331–156,626,590, forward strandHAPLN2BCAN: 156,641,390–156,659,532, forward strandBCANNES: 156,668,763–156,677,415, reverse strandNESCRABP2: 156,699,592–156,708,094, reverse strandCRABP2ISG20L2: 156,720,651–156,728,836, reverse strandMETTL25B: 156,728,442–156,736,960, forward strandMETTL25BMRPL24: 156,737,292–156,741,590, reverse strandMRPL24HDGF: 156,742,109–156,766,925, reverse strandHDGFPRCC: 156,750,610–156,800,818, forward strandPRCCSH2D2A: 156,806,235–156,817,014, reverse strandSH2D2AINSRR: 156,840,063–156,859,122, reverse strandINSRRNTRK1: 156,860,865–156,881,850, forward strandNTRK1PEAR1: 156,893,656–156,916,432, forward strandPEAR1LRRC71: 156,920,631–156,934,915, forward strandLRRC71ARHGEF11: 156,934,840–157,046,903, reverse strandARHGEF11ETV3L: 157,092,043–157,117,877, reverse strandETV3LETV3: 157,121,191–157,138,952, reverse strandETV3Diagram of NTRK1: 17 exons on the forward strand of chromosome 1Exon 1: 15 known disease-causing sitesExon 2: 6 known disease-causing sitesExon 3: 3 known disease-causing sitesExon 4: 5 known disease-causing sitesExon 5: 10 known disease-causing sitesExon 6: 5 known disease-causing sitesExon 7: 3 known disease-causing sitesExon 8: 13 known disease-causing sitesExon 10: 1 known disease-causing siteExon 11: 6 known disease-causing sitesExon 12: 6 known disease-causing sitesExon 13: 6 known disease-causing sitesExon 14: 25 known disease-causing sitesExon 15: 13 known disease-causing sitesExon 16: 18 known disease-causing sitesExon 17: 9 known disease-causing sitesExon 1: 156,860,865–156,861,146, 282 basesExon 2: 156,864,354–156,864,428, 75 basesExon 3: 156,864,728–156,864,799, 72 basesExon 4: 156,866,910–156,866,978, 69 basesExon 5: 156,868,104–156,868,249, 146 basesExon 6: 156,868,505–156,868,647, 143 basesExon 7: 156,871,623–156,871,755, 133 basesExon 8: 156,873,633–156,873,959, 327 basesExon 9: 156,874,383–156,874,400, 18 basesExon 10: 156,874,571–156,874,626, 56 basesExon 11: 156,874,906–156,875,008, 103 basesExon 12: 156,875,520–156,875,666, 147 basesExon 13: 156,876,080–156,876,210, 131 basesExon 14: 156,876,400–156,876,572, 173 basesExon 15: 156,879,122–156,879,362, 241 basesExon 16: 156,879,999–156,880,157, 159 basesExon 17: 156,881,457–156,881,850, 394 bases1246810121416175′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.7 kb of the gene's 21 kb; 2,391 of those bases code for the protein.

How a genome test reads NTRK1

177

positions in NTRK1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 21 kb of NTRK1, introns included, not only the 2.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). NTRK1 gene: neurotrophic receptor tyrosine kinase 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/ntrk1

Vancouver

Dante Labs. NTRK1 gene: neurotrophic receptor tyrosine kinase 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/ntrk1

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