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Gene

GRIA3

glutamate ionotropic receptor AMPA type subunit 3

Summary

Cytogenetic location
Xq25
Coordinates
Chromosome X: 123,184,278–123,490,915 (GRCh38)
Exons
16 exons across 306.6 kb
Protein
894 amino acids
Also known as
GluA3, GLURC, MRX94, GluR-3, GluR-C, GluR-K3, iGluR3
Previous symbols
GLUR3
MANE Select transcript
ENST00000620443.2NM_007325.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Epilepsy (Full Panel)

    • X-Linked Complex Neurodevelopmental Disorder

      A complex neurodevelopmental disorder that is transmitted via X-linked inheritance, and is characterized by intellectual disability, autism and epilepsy.

      • ClinGen rates the link definitive
      • 1 GenCC submitter rates it definitive or strong

Broader groupings

How GRIA3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome X, with a bracket where GRIA3 sits. GRIA3 and 1 gene near it on chromosome X, from 122,837,597 to 123,837,596.Chromosome XXq25p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q28123 Mb123.2 Mb123.4 Mb123.6 Mb123.8 MbGRIA3: 123,184,278–123,490,915, forward strandGRIA3THOC2: 123,600,561–123,733,061, reverse strandTHOC2Diagram of GRIA3: 16 exons on the forward strand of chromosome XExon 3: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 8: 2 known disease-causing sitesExon 10: 3 known disease-causing sitesExon 11: 1 known disease-causing siteExon 12: 6 known disease-causing sitesExon 13: 1 known disease-causing siteExon 14: 3 known disease-causing sitesExon 1: 123,184,278–123,184,644, 367 basesExon 2: 123,185,832–123,185,990, 159 basesExon 3: 123,253,303–123,253,542, 240 basesExon 4: 123,326,026–123,326,213, 188 basesExon 5: 123,354,910–123,354,963, 54 basesExon 6: 123,394,968–123,395,129, 162 basesExon 7: 123,398,636–123,398,803, 168 basesExon 8: 123,402,994–123,403,098, 105 basesExon 9: 123,403,412–123,403,519, 108 basesExon 10: 123,404,708–123,404,914, 207 basesExon 11: 123,417,402–123,417,778, 377 basesExon 12: 123,427,941–123,428,139, 199 basesExon 13: 123,464,865–123,465,112, 248 basesExon 14: 123,480,063–123,480,177, 115 basesExon 15: 123,482,799–123,483,046, 248 basesExon 16: 123,488,713–123,490,915, 2,203 bases110165′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.1 kb of the gene's 306.6 kb; 2,685 of those bases code for the protein.

How a genome test reads GRIA3

19

positions in GRIA3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 306.6 kb of GRIA3, introns included, not only the 5.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). GRIA3 gene: glutamate ionotropic receptor AMPA type subunit 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/gria3

Vancouver

Dante Labs. GRIA3 gene: glutamate ionotropic receptor AMPA type subunit 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/gria3

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