Gene
LIFR
LIF receptor subunit alpha
- HGNC 6597(opens in a new tab)
- Ensembl gene ENSG00000113594(opens in a new tab)
- NCBI Gene 3977(opens in a new tab)
Summary
- Cytogenetic location
- 5p13.1
- Coordinates
- Chromosome 5: 38,474,668–38,556,646 (GRCh38)
- Exons
- 20 exons across 82 kb
- Protein
- 1,097 amino acids
- Also known as
- CD118
- MANE Select transcript
- ENST00000453190.7NM_001127671.2
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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No Genome Test report reads LIFR yet. The test sequences your whole genome, so your data includes it all the same.
How LIFR is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 10.6 kb of the gene's 82 kb; 3,294 of those bases code for the protein.
How a genome test reads LIFR
85
positions in LIFR where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 82 kb of LIFR, introns included, not only the 10.6 kb of exons.
Traits linked to LIFR
The Human Phenotype Ontology lists these as features of the rare conditions LIFR can cause. Each trait's page lists the other genes linked to it.
Abnormality of limbs
- Bowed thighbone
- Contracture of the proximal interphalangeal joint of the 5th finger
- Metaphyseal rarefaction
- Thickening of shaft or central part of long bones
- Abnormality of the wide portion of a long bone
- Bowing of the long bones
- Broad wide portion of long bone
- Permanent flexion of the finger
Show 20 more traits
- Smaller or shorter than typical limbs
- Absent knee jerk reflex
- Club feet
- Clubbing of fingers and toes
- Elbow flexion contracture
- Flexion contracture of finger
- Inability to straighten knee
- Knock knees
- Short fingers or toes
- Abnormal metaphyseal trabeculation
- Bowed shankbone
- Finger bends toward pinky
- Flared wide portion of long bone
- Flexion contracture of toe
- Inward turned thumb
- Short finger bones
- Short shinbone
- Single transverse palmar crease
- Talipes
- Talipes valgus
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). LIFR gene: LIF receptor subunit alpha. Retrieved 17 October 2026, from https://dantelabs.com/genes/lifr
Dante Labs. LIFR gene: LIF receptor subunit alpha [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/lifr
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