Gene
SCARF2
scavenger receptor class F member 2
- HGNC 19869↗(opens in a new tab)
- Ensembl gene ENSG00000244486↗(opens in a new tab)
- NCBI Gene 91179↗(opens in a new tab)
Summary
- Cytogenetic location
- 22q11.21
- Coordinates
- Chromosome 22: 20,424,584–20,437,825 (GRCh38)
- Exons
- 11 exons across 13.2 kb
- Protein
- 866 amino acids
- Also known as
- SREC-II, SREC2, HUMZD58C02
- MANE Select transcript
- ENST00000622235.5NM_182895.5
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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No Genome Test report reads SCARF2 yet. The test sequences your whole genome, so your data includes it all the same.
How SCARF2 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 3.5 kb of the gene's 13.2 kb; 2,601 of those bases code for the protein.
How a genome test reads SCARF2
5
positions in SCARF2 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 13.2 kb of SCARF2, introns included, not only the 3.5 kb of exons.
Traits linked to SCARF2
The Human Phenotype Ontology lists these as features of the rare conditions SCARF2 can cause. Each trait's page lists the other genes linked to it.
Abnormality of limbs
- Bunion
- Camptodactyly of 2nd-5th fingers
- Distal ulnar hypoplasia
- Dropped arches
- Elbow flexion contracture
- Knock knees
- Long big toe
- Radioulnar subluxation
Show 19 more traits
- Recurrent patellar dislocation
- Tapered finger
- Webbed skin of 2nd-3rd toes
- Long slender fingers
- Bowing of the long bones
- Dislocated radial head
- Long foot
- Slender long bones of hand
- Webbed 2nd and 3rd toes
- Club feet
- Curvature of digit
- Knee contracture
- Bowed thighbone
- Camptodactyly of toe
- Curving of inner forearm bone
- Elongated long bone of hand
- Inability to straighten knee
- Joint contracture of the hand
- Narrow foot
Abnormality of head or neck
- Beaked nose
- Decreased size of maxilla
- Depressed nasal bridge
- Drooping lower lip
- High palate
- High, narrow palate
- Little lower jaw
- Narrow mouth
Show 15 more traits
- Narrow nose
- Narrow opening between the eyelids
- Scaphocephaly
- Triangular face
- Zygomatic flattening
- Downward slanting of the opening between the eyelids
- Facial asymmetry
- Abnormal columella morphology
- Deformity of the skull
- Dental crowding
- Deviated nasal septum
- Underdeveloped tissue around nostril
- Abnormality of the eyebrow
- Cleft palate
- Narrowing of the rear opening of the nasal cavity
Abnormality of the musculoskeletal system
- Double-Jointed
- Elbow contracture
- Hook-shaped collarbone
- Permanent flexion of the finger or toe
- Joint contracture
- Thin ribs
- Glenoid fossa hypoplasia
- Short collarbone
Show 4 more traits
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). SCARF2 gene: scavenger receptor class F member 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/scarf2
Dante Labs. SCARF2 gene: scavenger receptor class F member 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/scarf2
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