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Trait

Tracheobronchomalacia

Weakness of the cartilage in the trachea and the bronchi, resulting in a floppy (non-rigid) airway. Affected persons may have difficulties to maintain patency of the airways.

HPO HP:0002786

Summary

Body system
Abnormality of the respiratory system

10 condition reports read genes linked to this trait

Dante Labs condition reports look at the genes behind groups of inherited conditions, read from one whole-genome test. Each page says which conditions and genes a report covers, how it is read and what it cannot tell you.

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9 genes linked to Tracheobronchomalacia

Changes in these genes cause rare conditions in which Tracheobronchomalacia is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
FLNAfilamin AAlwaysIn 1 condition
POLR1ARNA polymerase I subunit AAlwaysIn 1 condition
SOX9SRY-box transcription factor 9Very often (80–99%)In 2 conditions
GMNNgeminin DNA replication inhibitorOften (30–79%)In 1 condition
SLC26A2solute carrier family 26 member 2Often (30–79%)In 1 condition
RAC1Rac family small GTPase 1Sometimes (5–29%)In 2 conditions
SCUBE3signal peptide, CUB domain and EGF like domain containing 3Sometimes (5–29%)In 1 condition
EHMT1euchromatic histone lysine methyltransferase 1Rarely (1–4%)In 1 condition
IDSiduronate 2-sulfataseNot recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

BronchomalaciaFloppy windpipe

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.19-9814e911.

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