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Gene

ADAM22

ADAM metallopeptidase domain 22

Summary

Cytogenetic location
7q21.12
Coordinates
Chromosome 7: 87,934,251–88,202,889 (GRCh38)
Exons
32 exons across 268.6 kb
Protein
964 amino acids
Also known as
MDC2
MANE Select transcript
ENST00000413139.2NM_001324418.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Epilepsy (Full Panel)

      • Epilepsy

        One of 171 genes linked to it

        A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

        • ClinGen rates the link definitive
        • 3 GenCC submitters rate it definitive or strong

    How ADAM22 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 7, with a bracket where ADAM22 sits. ADAM22 and 6 genes near it on chromosome 7, from 87,568,570 to 88,568,569.Chromosome 77q21.12p22.3p22.2p22.1p21.3p21.2p21.1p15.3p15.2p15.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.21q11.22q11.23q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q31.1q31.2q31.31q31.32q31.33q32.1q32.2q32.3q33q34q35q36.1q36.2q36.387.6 Mb87.8 Mb88 Mb88.2 Mb88.4 MbABCB1: 87,501,989–87,713,379, reverse strandABCB1RUNDC3B: 87,627,548–87,832,298, forward strandRUNDC3BSLC25A40: 87,833,561–87,876,404, reverse strandSLC25A40DBF4: 87,876,216–87,909,553, forward strandDBF4ADAM22: 87,934,251–88,202,889, forward strandADAM22SRI: 88,201,117–88,226,997, reverse strandSRISTEAP4: 88,270,892–88,307,061, reverse strandSTEAP4Diagram of ADAM22: 32 exons on the forward strand of chromosome 7Exon 23: 1 known disease-causing siteExon 32: 1 known disease-causing siteExon 1: 87,934,251–87,934,550, 300 basesExon 2: 87,935,026–87,935,186, 161 basesExon 3: 87,978,336–87,978,412, 77 basesExon 4: 88,075,626–88,075,692, 67 basesExon 5: 88,108,176–88,108,258, 83 basesExon 6: 88,114,584–88,114,647, 64 basesExon 7: 88,116,745–88,116,814, 70 basesExon 8: 88,125,589–88,125,659, 71 basesExon 9: 88,128,602–88,128,676, 75 basesExon 10: 88,130,388–88,130,459, 72 basesExon 11: 88,131,269–88,131,435, 167 basesExon 12: 88,132,867–88,132,951, 85 basesExon 13: 88,134,329–88,134,419, 91 basesExon 14: 88,135,980–88,136,031, 52 basesExon 15: 88,143,026–88,143,125, 100 basesExon 16: 88,145,125–88,145,196, 72 basesExon 17: 88,145,415–88,145,507, 93 basesExon 18: 88,148,977–88,149,057, 81 basesExon 19: 88,150,981–88,151,031, 51 basesExon 20: 88,151,257–88,151,320, 64 basesExon 21: 88,153,221–88,153,326, 106 basesExon 22: 88,155,887–88,156,006, 120 basesExon 23: 88,163,012–88,163,180, 169 basesExon 24: 88,165,832–88,165,946, 115 basesExon 25: 88,168,137–88,168,227, 91 basesExon 26: 88,171,544–88,171,561, 18 basesExon 27: 88,178,935–88,179,129, 195 basesExon 28: 88,181,505–88,181,605, 101 basesExon 29: 88,181,958–88,182,024, 67 basesExon 30: 88,186,615–88,186,701, 87 basesExon 31: 88,193,116–88,193,239, 124 basesExon 32: 88,196,471–88,202,889, 6,419 bases151015202530325′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 9.5 kb of the gene's 268.6 kb; 2,895 of those bases code for the protein.

    How a genome test reads ADAM22

    4

    positions in ADAM22 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 268.6 kb of ADAM22, introns included, not only the 9.5 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). ADAM22 gene: ADAM metallopeptidase domain 22. Retrieved 16 October 2026, from https://dantelabs.com/genes/adam22

    Vancouver

    Dante Labs. ADAM22 gene: ADAM metallopeptidase domain 22 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/adam22

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