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Gene

G6PD

glucose-6-phosphate dehydrogenase

Summary

Cytogenetic location
Xq28
Coordinates
Chromosome X: 154,531,391–154,546,846 (GRCh38)
Exons
13 exons across 15.5 kb
Protein
515 amino acids
Inheritance
X-linked recessive
Also known as
G6PD1
MANE Select transcript
ENST00000393562.10NM_001360016.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • G6PD Deficiency

    • X-linked recessive

      Glucose-6-phosphate dehydrogenase deficiency, predisposing to haemolytic anaemia triggered by oxidative stress.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      Avoidance of oxidant triggers (primaquine, rasburicase, dapsone, nitrofurantoin); management of acute hemolytic episodes (supportive, transfusion); neonatal phototherapy/exchange transfusion for hyperbilirubinemia; G6PD testing required before tafenoquine (FDA)

Inheritance

X-linked recessive
The change is on the X chromosome, so one copy affects males, who have one X, while females with one are usually carriers. A carrier mother passes it on to each child with a one-in-two chance.

How G6PD is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome X, with a bracket where G6PD sits. G6PD and 32 genes near it on chromosome X, from 154,039,119 to 155,039,118.Chromosome XXq28p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q28154.2 Mb154.4 Mb154.6 Mb154.8 Mb155 MbMECP2: 154,021,573–154,137,103, reverse strandMECP2OPN1LW: 154,144,243–154,159,032, forward strandOPN1LWOPN1MW: 154,182,596–154,196,861, forward strandOPN1MWOPN1MW2: 154,219,756–154,233,286, forward strandOPN1MW2OPN1MW3: 154,257,582–154,271,090, forward strandOPN1MW3TEX28: 154,271,265–154,295,853, reverse strandTEX28TKTL1: 154,295,795–154,330,350, forward strandTKTL1FLNA: 154,348,524–154,374,643, reverse strandEMD: 154,379,205–154,381,574, forward strandEMDRPL10: 154,389,955–154,409,168, forward strandRPL10DNASE1L1: 154,401,236–154,412,119, reverse strandDNASE1L1TAFAZZIN: 154,409,456–154,421,726, forward strandTAFAZZINATP6AP1: 154,428,618–154,436,517, forward strandGDI1: 154,436,600–154,443,467, forward strandFAM50A: 154,444,103–154,450,655, forward strandPLXNA3: 154,458,275–154,477,779, forward strandLAGE3: 154,477,598–154,479,291, reverse strandLAGE3UBL4A: 154,483,717–154,486,661, reverse strandUBL4ASLC10A3: 154,487,306–154,490,690, reverse strandSLC10A3FAM3A: 154,505,019–154,516,882, reverse strandFAM3AG6PD: 154,531,391–154,546,846, reverse strandG6PDIKBKG: 154,541,179–154,568,543, forward strandIKBKGCTAG1A: 154,585,133–154,586,816, forward strandCTAG1ACTAG1B: 154,617,609–154,619,282, reverse strandCTAG1BCTAG2: 154,651,972–154,653,579, reverse strandCTAG2GAB3: 154,675,249–154,751,583, reverse strandGAB3DKC1: 154,762,741–154,777,697, forward strandDKC1MPP1: 154,778,684–154,821,039, reverse strandMPP1SMIM9: 154,823,348–154,834,662, reverse strandSMIM9F8: 154,835,788–155,026,940, reverse strandF8H2AB1: 154,884,972–154,885,558, forward strandH2AB1F8A1: 154,886,355–154,888,061, forward strandF8A1FUNDC2: 155,025,980–155,065,641, forward strandFUNDC2Diagram of G6PD: 13 exons on the reverse strand of chromosome XExon 13: 4 known disease-causing sitesExon 12: 13 known disease-causing sitesExon 11: 16 known disease-causing sitesExon 10: 43 known disease-causing sitesExon 9: 19 known disease-causing sitesExon 8: 15 known disease-causing sitesExon 7: 15 known disease-causing sitesExon 6: 25 known disease-causing sitesExon 5: 25 known disease-causing sitesExon 4: 14 known disease-causing sitesExon 3: 4 known disease-causing sitesExon 2: 8 known disease-causing sitesExon 13: 154,531,391–154,532,090, 700 basesExon 12: 154,532,188–154,532,280, 93 basesExon 11: 154,532,386–154,532,462, 77 basesExon 10: 154,532,567–154,532,802, 236 basesExon 9: 154,532,942–154,533,128, 187 basesExon 8: 154,533,576–154,533,669, 94 basesExon 7: 154,534,035–154,534,160, 126 basesExon 6: 154,534,338–154,534,496, 159 basesExon 5: 154,535,168–154,535,385, 218 basesExon 4: 154,535,937–154,536,045, 109 basesExon 3: 154,536,141–154,536,178, 38 basesExon 2: 154,546,036–154,546,163, 128 basesExon 1: 154,546,789–154,546,846, 58 bases131210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.2 kb of the gene's 15.5 kb; 1,548 of those bases code for the protein.

How a genome test reads G6PD

209

positions in G6PD where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 15.5 kb of G6PD, introns included, not only the 2.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). G6PD gene: glucose-6-phosphate dehydrogenase. Retrieved 16 October 2026, from https://dantelabs.com/genes/g6pd

Vancouver

Dante Labs. G6PD gene: glucose-6-phosphate dehydrogenase [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/g6pd

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