Trait
Joint stiffness
Joint stiffness is a perceived sensation of tightness in a joint or joints when attempting to move them after a period of inactivity. Joint stiffness typically subsides over time.
Summary
- Also called
- Stiff joint, Stiff joints
- Body system
- Abnormality of the musculoskeletal system
Reference genomeGRCh38hg38
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Get my Genome Test187 genes linked to Joint stiffness
Changes in these genes cause rare conditions in which Joint stiffness is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ADAMTS10ADAM metallopeptidase with thrombospondin type 1 motif 10 | Always | In 2 conditions |
| ADAMTSL2ADAMTS like 2 | Always | In 1 condition |
| BANF1barrier to autointegration nuclear assembly factor 1 | Always | In 1 condition |
| COL2A1collagen type II alpha 1 chain | Always | In 4 conditions |
| GLB1galactosidase beta 1 | Always | In 3 conditions |
| GNPTGN-acetylglucosamine-1-phosphate transferase subunit gamma | Always | In 1 condition |
| IDUAalpha-L-iduronidase | Always | In 3 conditions |
| KRT83keratin 83 | Always | In 1 condition |
| LMNAlamin A/C | Always | In 4 conditions |
| SMAD4SMAD family member 4 | Always | In 2 conditions |
| UBAP2Lubiquitin associated protein 2 like | Always | In 1 condition |
| ADAMTSL4ADAMTS like 4 | Very often (80–99%) | In 1 condition |
| ANTXR2ANTXR cell adhesion molecule 2 | Very often (80–99%) | In 2 conditions |
| ATAD1ATPase family AAA domain containing 1 | Very often (80–99%) | In 1 condition |
| BMPR1Bbone morphogenetic protein receptor type 1B | Very often (80–99%) | In 1 condition |
| EMDemerin | Very often (80–99%) | In 1 condition |
| EMG1EMG1 N1-specific pseudouridine methyltransferase | Very often (80–99%) | In 1 condition |
| ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit | Very often (80–99%) | In 1 condition |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Very often (80–99%) | In 1 condition |
| ERCC5ERCC excision repair 5, endonuclease | Very often (80–99%) | In 1 condition |
| ERCC6ERCC excision repair 6, chromatin remodeling factor | Very often (80–99%) | In 1 condition |
| FBN1fibrillin 1 | Very often (80–99%) | In 6 conditions |
| FBN2fibrillin 2 | Very often (80–99%) | In 1 condition |
| FGF9fibroblast growth factor 9 | Very often (80–99%) | In 1 condition |
| FHL1four and a half LIM domains 1 | Very often (80–99%) | In 1 condition |
| FKBP10FKBP prolyl isomerase 10 | Very often (80–99%) | In 2 conditions |
| GDF5growth differentiation factor 5 | Very often (80–99%) | In 3 conditions |
| GDF6growth differentiation factor 6 | Very often (80–99%) | In 1 condition |
| GLRA1glycine receptor alpha 1 | Very often (80–99%) | In 1 condition |
| GLRBglycine receptor beta | Very often (80–99%) | In 1 condition |
| GNPTABN-acetylglucosamine-1-phosphate transferase subunits alpha and beta | Very often (80–99%) | In 1 condition |
| GPHNgephyrin | Very often (80–99%) | In 1 condition |
| HGDhomogentisate 1,2-dioxygenase | Very often (80–99%) | In 1 condition |
| HLA-Bmajor histocompatibility complex, class I, B | Very often (80–99%) | In 2 conditions |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Very often (80–99%) | In 1 condition |
| HSPG2heparan sulfate proteoglycan 2 | Very often (80–99%) | In 2 conditions |
| IRF6interferon regulatory factor 6 | Very often (80–99%) | In 1 condition |
| LSSlanosterol synthase | Very often (80–99%) | In 1 condition |
| MACROH2A1macroH2A.1 histone | Very often (80–99%) | In 1 condition |
| MFN2mitofusin 2 | Very often (80–99%) | In 1 condition |
Show 147 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| MMP13matrix metallopeptidase 13 | Very often (80–99%) | In 1 condition |
| MMP9matrix metallopeptidase 9 | Very often (80–99%) | In 1 condition |
| MYH3myosin heavy chain 3 | Very often (80–99%) | In 3 conditions |
| NALCNsodium leak channel, non-selective | Very often (80–99%) | In 3 conditions |
| NOGnoggin | Very often (80–99%) | In 1 condition |
| P4HA2prolyl 4-hydroxylase subunit alpha 2 | Very often (80–99%) | In 1 condition |
| PAX3paired box 3 | Very often (80–99%) | In 1 condition |
| PIEZO2piezo type mechanosensitive ion channel component 2 | Very often (80–99%) | In 2 conditions |
| PITX1paired like homeodomain 1 | Very often (80–99%) | In 1 condition |
| PLOD2procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 | Very often (80–99%) | In 1 condition |
| PTPN22protein tyrosine phosphatase non-receptor type 22 | Very often (80–99%) | In 2 conditions |
| RAB18RAB18, member RAS oncogene family | Very often (80–99%) | In 1 condition |
| RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1 | Very often (80–99%) | In 1 condition |
| RAB3GAP2RAB3 GTPase activating non-catalytic protein subunit 2 | Very often (80–99%) | In 1 condition |
| SALL4spalt like transcription factor 4 | Very often (80–99%) | In 1 condition |
| SHOXSHOX homeobox | Very often (80–99%) | In 1 condition |
| SLC6A5solute carrier family 6 member 5 | Very often (80–99%) | In 1 condition |
| SYNE1spectrin repeat containing nuclear envelope protein 1 | Very often (80–99%) | In 1 condition |
| SYNE2spectrin repeat containing nuclear envelope protein 2 | Very often (80–99%) | In 1 condition |
| TBC1D20TBC1 domain family member 20 | Very often (80–99%) | In 1 condition |
| TBX5T-box transcription factor 5 | Very often (80–99%) | In 1 condition |
| TMEM43transmembrane protein 43 | Very often (80–99%) | In 1 condition |
| TNNI2troponin I2, fast skeletal type | Very often (80–99%) | In 2 conditions |
| TNNT3troponin T3, fast skeletal type | Very often (80–99%) | In 2 conditions |
| TPM2tropomyosin 2 | Very often (80–99%) | In 2 conditions |
| TRPV4transient receptor potential cation channel subfamily V member 4 | Very often (80–99%) | In 2 conditions |
| ACTBactin beta | Often (30–79%) | In 1 condition |
| ACTG1actin gamma 1 | Often (30–79%) | In 1 condition |
| ANKRD55ankyrin repeat domain 55 | Often (30–79%) | In 1 condition |
| ASPAaspartoacylase | Often (30–79%) | In 1 condition |
| BAZ1Bbromodomain adjacent to zinc finger domain 1B | Often (30–79%) | In 1 condition |
| BRD4bromodomain containing 4 | Often (30–79%) | In 1 condition |
| BUD23BUD23 rRNA methyltransferase and ribosome maturation factor | Often (30–79%) | In 1 condition |
| CBScystathionine beta-synthase | Often (30–79%) | In 1 condition |
| CD247CD247 molecule | Often (30–79%) | In 1 condition |
| CHST11carbohydrate sulfotransferase 11 | Often (30–79%) | In 1 condition |
| CLIP2CAP-Gly domain containing linker protein 2 | Often (30–79%) | In 1 condition |
| DNAJC30DnaJ heat shock protein family (Hsp40) member C30 | Often (30–79%) | In 1 condition |
| EIF4Heukaryotic translation initiation factor 4H | Often (30–79%) | In 1 condition |
| ELNelastin | Often (30–79%) | In 1 condition |
| EZH2enhancer of zeste 2 polycomb repressive complex 2 subunit | Often (30–79%) | In 1 condition |
| FKBP6FKBP prolyl isomerase family member 6 (inactive) | Often (30–79%) | In 1 condition |
| FUZfuzzy planar cell polarity protein | Often (30–79%) | In 1 condition |
| GTF2Igeneral transcription factor IIi | Often (30–79%) | In 1 condition |
| GTF2IRD1GTF2I repeat domain containing 1 | Often (30–79%) | In 1 condition |
| GTF2IRD2GTF2I repeat domain containing 2 | Often (30–79%) | In 1 condition |
| GUSBglucuronidase beta | Often (30–79%) | In 2 conditions |
| HDAC8histone deacetylase 8 | Often (30–79%) | In 1 condition |
| HPGD15-hydroxyprostaglandin dehydrogenase | Often (30–79%) | In 1 condition |
| IDH1isocitrate dehydrogenase (NADP(+)) 1 | Often (30–79%) | In 1 condition |
| IDH2isocitrate dehydrogenase (NADP(+)) 2 | Often (30–79%) | In 1 condition |
| IL2RAinterleukin 2 receptor subunit alpha | Often (30–79%) | In 1 condition |
| IL2RBinterleukin 2 receptor subunit beta | Often (30–79%) | In 1 condition |
| LIMK1LIM domain kinase 1 | Often (30–79%) | In 1 condition |
| LTBP2latent transforming growth factor beta binding protein 2 | Often (30–79%) | In 2 conditions |
| MAU2MAU2 sister chromatid cohesion factor | Often (30–79%) | In 1 condition |
| METTL27methyltransferase like 27 | Often (30–79%) | In 1 condition |
| MYBPC1myosin binding protein C1 | Often (30–79%) | In 1 condition |
| NCF1neutrophil cytosolic factor 1 | Often (30–79%) | In 1 condition |
| NIPBLNIPBL cohesin loading factor | Often (30–79%) | In 1 condition |
| NPR2natriuretic peptide receptor 2 | Often (30–79%) | In 1 condition |
| NSD1nuclear receptor binding SET domain protein 1 | Often (30–79%) | In 1 condition |
| POMT1protein O-mannosyltransferase 1 | Often (30–79%) | In 1 condition |
| PTH1Rparathyroid hormone 1 receptor | Often (30–79%) | In 1 condition |
| PTPN2protein tyrosine phosphatase non-receptor type 2 | Often (30–79%) | In 1 condition |
| RAD21RAD21 cohesin complex component | Often (30–79%) | In 1 condition |
| RFC2replication factor C subunit 2 | Often (30–79%) | In 1 condition |
| SCUBE3signal peptide, CUB domain and EGF like domain containing 3 | Often (30–79%) | In 1 condition |
| SF3B4splicing factor 3b subunit 4 | Often (30–79%) | In 1 condition |
| SH3PXD2BSH3 and PX domains 2B | Often (30–79%) | In 1 condition |
| SLC26A2solute carrier family 26 member 2 | Often (30–79%) | In 2 conditions |
| SMC1Astructural maintenance of chromosomes 1A | Often (30–79%) | In 1 condition |
| SMC3structural maintenance of chromosomes 3 | Often (30–79%) | In 1 condition |
| STAT4signal transducer and activator of transcription 4 | Often (30–79%) | In 1 condition |
| STING1stimulator of interferon response cGAMP interactor 1 | Often (30–79%) | In 1 condition |
| STX1Asyntaxin 1A | Often (30–79%) | In 1 condition |
| SUMF1sulfatase modifying factor 1 | Often (30–79%) | In 1 condition |
| SUZ12SUZ12 polycomb repressive complex 2 subunit | Often (30–79%) | In 1 condition |
| TBL2transducin beta like 2 | Often (30–79%) | In 1 condition |
| TGDSTDP-glucose 4,6-dehydratase | Often (30–79%) | In 1 condition |
| TMEM270transmembrane protein 270 | Often (30–79%) | In 1 condition |
| USB1U6 snRNA biogenesis phosphodiesterase 1 | Often (30–79%) | In 1 condition |
| VANGL1VANGL planar cell polarity protein 1 | Often (30–79%) | In 1 condition |
| VPS33AVPS33A core subunit of CORVET and HOPS complexes | Often (30–79%) | In 1 condition |
| VPS37DVPS37D subunit of ESCRT-I | Often (30–79%) | In 1 condition |
| ACTG2actin gamma 2, smooth muscle | Sometimes (5–29%) | In 1 condition |
| ADAMTS17ADAM metallopeptidase with thrombospondin type 1 motif 17 | Sometimes (5–29%) | In 1 condition |
| AGAaspartylglucosaminidase | Sometimes (5–29%) | In 1 condition |
| AKT1AKT serine/threonine kinase 1 | Sometimes (5–29%) | In 1 condition |
| ANKHANKH inorganic pyrophosphate transport regulator | Sometimes (5–29%) | In 1 condition |
| ATRXATRX chromatin remodeler | Sometimes (5–29%) | In 1 condition |
| BMP6bone morphogenetic protein 6 | Sometimes (5–29%) | In 1 condition |
| CASZ1castor zinc finger 1 | Sometimes (5–29%) | In 1 condition |
| CCN2cellular communication network factor 2 | Sometimes (5–29%) | In 1 condition |
| CHMP1Acharged multivesicular body protein 1A | Sometimes (5–29%) | In 1 condition |
| CISD2CDGSH iron sulfur domain 2 | Sometimes (5–29%) | In 1 condition |
| COMPcartilage oligomeric matrix protein | Sometimes (5–29%) | In 3 conditions |
| EPG5ectopic P-granules 5 autophagy tethering factor | Sometimes (5–29%) | In 1 condition |
| FGFR3fibroblast growth factor receptor 3 | Sometimes (5–29%) | In 1 condition |
| GABRDgamma-aminobutyric acid type A receptor subunit delta | Sometimes (5–29%) | In 1 condition |
| HFEhomeostatic iron regulator | Sometimes (5–29%) | In 1 condition |
| HGSNATheparan-alpha-glucosaminide N-acetyltransferase | Sometimes (5–29%) | In 1 condition |
| INPPL1inositol polyphosphate phosphatase like 1 | Sometimes (5–29%) | In 1 condition |
| KCNAB2potassium voltage-gated channel subfamily A regulatory beta subunit 2 | Sometimes (5–29%) | In 1 condition |
| L1CAML1 cell adhesion molecule | Sometimes (5–29%) | In 1 condition |
| LEMD3LEM domain containing 3 | Sometimes (5–29%) | In 2 conditions |
| LTBP3latent transforming growth factor beta binding protein 3 | Sometimes (5–29%) | In 1 condition |
| LUZP1leucine zipper protein 1 | Sometimes (5–29%) | In 1 condition |
| MAN2B1mannosidase alpha class 2B member 1 | Sometimes (5–29%) | In 1 condition |
| MATN3matrilin 3 | Sometimes (5–29%) | In 1 condition |
| MECP2methyl-CpG binding protein 2 | Sometimes (5–29%) | In 1 condition |
| MMP23Bmatrix metallopeptidase 23B | Sometimes (5–29%) | In 1 condition |
| MTX2metaxin 2 | Sometimes (5–29%) | In 1 condition |
| NAE1NEDD8 activating enzyme E1 subunit 1 | Sometimes (5–29%) | In 1 condition |
| OCRLOCRL inositol polyphosphate-5-phosphatase | Sometimes (5–29%) | In 1 condition |
| PDPNpodoplanin | Sometimes (5–29%) | In 1 condition |
| PNKDPNKD metallo-beta-lactamase domain containing | Sometimes (5–29%) | In 1 condition |
| PPP1R12Aprotein phosphatase 1 regulatory subunit 12A | Sometimes (5–29%) | In 1 condition |
| PRDM16PR/SET domain 16 | Sometimes (5–29%) | In 1 condition |
| PRKCZprotein kinase C zeta | Sometimes (5–29%) | In 1 condition |
| PRRT2proline rich transmembrane protein 2 | Sometimes (5–29%) | In 1 condition |
| RAI1retinoic acid induced 1 | Sometimes (5–29%) | In 1 condition |
| REREarginine-glutamic acid dipeptide repeats | Sometimes (5–29%) | In 1 condition |
| RNU4ATACRNA, U4atac small nuclear | Sometimes (5–29%) | In 1 condition |
| SKISKI proto-oncogene | Sometimes (5–29%) | In 2 conditions |
| SPENspen family transcriptional repressor | Sometimes (5–29%) | In 1 condition |
| TNFRSF11BTNF receptor superfamily member 11b | Sometimes (5–29%) | In 1 condition |
| UBE4Bubiquitination factor E4B | Sometimes (5–29%) | In 1 condition |
| VAPBVAMP associated protein B and C | Sometimes (5–29%) | In 1 condition |
| WFS1wolframin ER transmembrane glycoprotein | Sometimes (5–29%) | In 1 condition |
| WRNWRN RecQ like helicase | Sometimes (5–29%) | In 1 condition |
| ZMPSTE24zinc metallopeptidase STE24 | Sometimes (5–29%) | In 1 condition |
| FLNAfilamin A | Rarely (1–4%) | In 1 condition |
| PTBP1polypyrimidine tract binding protein 1 | Rarely (1–4%) | In 1 condition |
| ARSBarylsulfatase B | Not recorded | In 1 condition |
| ASPNasporin | Not recorded | In 1 condition |
| CCN6cellular communication network factor 6 | Not recorded | In 1 condition |
| CD244CD244 molecule | Not recorded | In 1 condition |
| CIITAclass II major histocompatibility complex transactivator | Not recorded | In 1 condition |
| GNSglucosamine (N-acetyl)-6-sulfatase | Not recorded | In 1 condition |
| IL10interleukin 10 | Not recorded | In 1 condition |
| NAGLUN-acetyl-alpha-glucosaminidase | Not recorded | In 1 condition |
| NFKBIL1NFKB inhibitor like 1 | Not recorded | In 1 condition |
| PCYT1Aphosphate cytidylyltransferase 1A, choline | Not recorded | In 1 condition |
| PTF1Apancreas associated transcription factor 1a | Not recorded | In 1 condition |
| SGSHN-sulfoglucosamine sulfohydrolase | Not recorded | In 1 condition |
| SLC22A4solute carrier family 22 member 4 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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