Trait
Hanging skin
Clinical name: Cutis laxa
Wrinkled, redundant, inelastic and sagging skin.
Summary
- Also called
- Loose and inelastic skin, Chalazoderma, Cutaneous laxity, Dermatochalasia, Dermatomegaly, Elastolysis, Generalised elastolysis, Generalized elastolysis, Hypoelastic skin, Inelastic skin, Lax skin, Loose skin, Skin laxity
- Body system
- Abnormality of the integument
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test63 genes linked to Hanging skin
Changes in these genes cause rare conditions in which Hanging skin is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ALDH18A1aldehyde dehydrogenase 18 family member A1 | Always | In 3 conditions |
| ATP6AP1ATPase H+ transporting accessory protein 1 | Always | In 1 condition |
| ATP6AP2ATPase H+ transporting accessory protein 2 | Always | In 1 condition |
| ATP6V1AATPase H+ transporting V1 subunit A | Always | In 2 conditions |
| EFEMP2EGF-like fibulin extracellular matrix protein 2 | Always | In 2 conditions |
| FBLN5fibulin 5 | Always | In 4 conditions |
| FKBP14FKBP prolyl isomerase 14 | Always | In 1 condition |
| GGCXgamma-glutamyl carboxylase | Always | In 3 conditions |
| GNB2G protein subunit beta 2 | Always | In 1 condition |
| IFT140intraflagellar transport 140 | Always | In 1 condition |
| LTBP1latent transforming growth factor beta binding protein 1 | Always | In 2 conditions |
| LTBP4latent transforming growth factor beta binding protein 4 | Always | In 1 condition |
| NBASNBAS subunit of NRZ tethering complex | Always | In 1 condition |
| PTBP1polypyrimidine tract binding protein 1 | Always | In 1 condition |
| PTDSS1phosphatidylserine synthase 1 | Always | In 1 condition |
| PYCR1pyrroline-5-carboxylate reductase 1 | Always | In 2 conditions |
| RMP64ribonuclease MRP subunit p64 | Always | In 1 condition |
| WDR19WD repeat domain 19 | Always | In 1 condition |
| ATP6V0A2ATPase H+ transporting V0 subunit a2 | Very often (80–99%) | In 3 conditions |
| ATP6V1E1ATPase H+ transporting V1 subunit E1 | Very often (80–99%) | In 2 conditions |
| B4GALT7beta-1,4-galactosyltransferase 7 | Very often (80–99%) | In 1 condition |
| ELNelastin | Very often (80–99%) | In 3 conditions |
| FBN1fibrillin 1 | Very often (80–99%) | In 1 condition |
| SLC25A24solute carrier family 25 member 24 | Very often (80–99%) | In 1 condition |
| AARS1alanyl-tRNA synthetase 1 | Often (30–79%) | In 1 condition |
| ABCC6ATP binding cassette subfamily C member 6 | Often (30–79%) | In 1 condition |
| B3GALT6beta-1,3-galactosyltransferase 6 | Often (30–79%) | In 1 condition |
| EMILIN1elastin microfibril interfacer 1 | Often (30–79%) | In 1 condition |
| EZH2enhancer of zeste 2 polycomb repressive complex 2 subunit | Often (30–79%) | In 1 condition |
| GSNgelsolin | Often (30–79%) | In 2 conditions |
| MAN1B1mannosidase alpha class 1B member 1 | Often (30–79%) | In 2 conditions |
| MEGF8multiple EGF like domains 8 | Often (30–79%) | In 1 condition |
| MLXIPLMLX interacting protein like | Often (30–79%) | In 1 condition |
| NAA10N-alpha-acetyltransferase 10, NatA catalytic subunit | Often (30–79%) | In 2 conditions |
| PTENphosphatase and tensin homolog | Often (30–79%) | In 1 condition |
| RNU5B-1RNA, U5B small nuclear 1 | Often (30–79%) | In 1 condition |
| SLC2A10solute carrier family 2 member 10 | Often (30–79%) | In 1 condition |
| XYLT1xylosyltransferase 1 | Often (30–79%) | In 1 condition |
| XYLT2xylosyltransferase 2 | Often (30–79%) | In 1 condition |
| ALG8ALG8 alpha-1,3-glucosyltransferase | Sometimes (5–29%) | In 1 condition |
Show 23 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| ASXL1ASXL transcriptional regulator 1 | Sometimes (5–29%) | In 1 condition |
| DLK1delta like non-canonical Notch ligand 1 | Sometimes (5–29%) | In 1 condition |
| EFEMP1EGF-like fibulin extracellular matrix protein 1 | Sometimes (5–29%) | In 1 condition |
| IPO8importin 8 | Sometimes (5–29%) | In 1 condition |
| MEG3maternally expressed 3 | Sometimes (5–29%) | In 1 condition |
| RTL1retrotransposon Gag like 1 | Sometimes (5–29%) | In 1 condition |
| SPINT2serine peptidase inhibitor, Kunitz type 2 | Sometimes (5–29%) | In 1 condition |
| VIPAS39VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog | Sometimes (5–29%) | In 1 condition |
| VKORC1vitamin K epoxide reductase complex subunit 1 | Sometimes (5–29%) | In 1 condition |
| VPS33BVPS33B late endosome and lysosome associated | Sometimes (5–29%) | In 1 condition |
| FLNAfilamin A | Rarely (1–4%) | In 1 condition |
| ATP7AATPase copper transporting alpha | Not recorded | In 1 condition |
| B3GAT3beta-1,3-glucuronyltransferase 3 | Not recorded | In 1 condition |
| BCL11BBCL11 transcription factor B | Not recorded | In 1 condition |
| CD96CD96 molecule | Not recorded | In 1 condition |
| CHST3carbohydrate sulfotransferase 3 | Not recorded | In 1 condition |
| GORABgolgin, RAB6 interacting | Not recorded | In 1 condition |
| IFT43intraflagellar transport 43 | Not recorded | In 1 condition |
| RIN2Ras and Rab interactor 2 | Not recorded | In 1 condition |
| RPS6KA3ribosomal protein S6 kinase A3 | Not recorded | In 1 condition |
| SLC7A7solute carrier family 7 member 7 | Not recorded | In 1 condition |
| SRD5A3steroid 5 alpha-reductase 3 | Not recorded | In 1 condition |
| WDR35WD repeat domain 35 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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